Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102687 - 102687
Опубликована: Фев. 1, 2025
Язык: Английский
Metabolism, Год журнала: 2021, Номер 125, С. 154910 - 154910
Опубликована: Окт. 8, 2021
Язык: Английский
Процитировано
134
Frontiers in Endocrinology, Год журнала: 2022, Номер 13
Опубликована: Сен. 26, 2022
Irisin, out-membrane part of fibronectin type III domain–containing 5 protein (FNDC5), was activated by Peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) during physical exercise in skeletal muscle tissues. Most studies have reported that the concentration irisin is highly associated with health status. For instance, level significantly lower patients obesity, osteoporosis/fractures, atrophy, Alzheimer’s disease, and cardiovascular diseases (CVDs) but higher cancer. Irisin can bind to its integrin αV/β5 induce browning white fat, maintain glucose stability, keep bone homeostasis, alleviate cardiac injury. However, it unclear whether works directly binding receptors regulate regeneration, promote neurogenesis, liver inhibit cancer development. Supplementation recombinant or exercise-activated might be a successful strategy fight osteoporosis, injury, CVDs one go. Here, we summarize publications FNDC5/irisin from PubMed/Medline, Scopus, Web Science until March 2022, review role physiology pathology.
Язык: Английский
Процитировано
81
Cell Death Discovery, Год журнала: 2023, Номер 9(1)
Опубликована: Июль 21, 2023
Abstract Diabetic cardiomyopathy (DCM) mainly refers to myocardial metabolic dysfunction caused by high glucose, and hyperglycemia is an independent risk factor for cardiac function in the absence of coronary atherosclerosis hypertension. DCM, which a severe complication diabetes, has become leading cause heart failure diabetic patients. The initial symptoms are inconspicuous, patients gradually exhibit left ventricular eventually develop total failure, brings great challenge early diagnosis DCM. To date, underlying pathological mechanisms DCM complicated have not been fully elucidated. Although there therapeutic strategies available treatment focused on controlling blood glucose lipids, lack effective drugs targeting injury. Thus, large percentage with inevitably failure. Given neglected symptoms, intricate cellular molecular mechanisms, drugs, it necessary explore diagnostic biomarkers, further understand signaling pathways involved pathogenesis summarize current strategies, new targeted interventions.
Язык: Английский
Процитировано
56
Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)
Опубликована: Апрель 2, 2024
Abstract Background Diabetic cardiomyopathy (DCM) is a serious complication in patients with type 1 diabetes mellitus (T1DM), which still lacks adequate therapy. Irisin, cleavage peptide off fibronectin III domain-containing 5, has been shown to preserve cardiac function ischemia–reperfusion injury. Whether or not irisin plays cardioprotective role DCM known. Methods and results T1DM was induced by multiple low-dose intraperitoneal injections of streptozotocin (STZ). Our current study showed that expression/level lower the heart serum mice STZ-induced TIDM. Irisin supplementation injection improved impaired DCM, ascribed inhibition ferroptosis, because increased associated malondialdehyde (MDA), decreased reduced glutathione (GSH) protein expressions solute carrier family 7 member 11 (SLC7A11) peroxidase 4 (GPX4), ameliorated irisin. In presence erastin, ferroptosis inducer, irisin-mediated protective effects were blocked. Mechanistically, treatment Sirtuin (SIRT1) p53 K382 acetylation, expression increasing its degradation, consequently upregulated SLC7A11 GPX4 expressions. Thus, reduction decreases protects cardiomyocytes against injury due high glucose. Conclusion This demonstrated could improve suppressing via SIRT1-p53-SLC7A11/GPX4 pathway. may be therapeutic approach management T1DM-induced cardiomyopathy.
Язык: Английский
Процитировано
28
Stem Cell Research & Therapy, Год журнала: 2021, Номер 12(1)
Опубликована: Сен. 28, 2021
Abstract Background Exosomes are considered a substitute for stem cell-based therapy myocardial infarction (MI). FNDC5, transmembrane protein located in the cytoplasm, plays crucial role inflammation diseases and MI repair. Furthermore, our previous study found that FNDC5 pre-conditioning bone marrow-derived mesenchymal cells (BMMSCs) could secrete more exosomes, but little was known on Methods isolated from BMMSCs with or without FNDC5-OV were injected into infarcted hearts. Then, cardiomyocytes apoptosis responses detected. exosomes administrated to RAW264.7 macrophage LPS treatment investigate its effect polarization. Results Compared MSCs-Exo, FNDC5-MSCs-Exo had superior therapeutic effects anti-inflammation anti-apoptosis, as well polarizing M2 vivo. Meanwhile, vitro results also showed decreased pro-inflammatory secretion increased anti-inflammatory under stimulation, which partly depressed NF‐κB signaling pathway upregulated Nrf2/HO-1 Axis. Conclusions FNDC5-BMMSCs-derived play promote polarization via NF-κB Axis, may develop promising cell-free MI.
Язык: Английский
Процитировано
69
Aging Cell, Год журнала: 2022, Номер 21(3)
Опубликована: Фев. 15, 2022
Abstract Aging is an important risk factor for cardiovascular diseases, and aging‐related cardiac dysfunction serves as a major determinant of morbidity mortality in elderly populations. Our previous study has identified fibronectin type III domain‐containing 5 (FNDC5) its cleaved form, irisin, the cardioprotectant against doxorubicin‐induced cardiomyopathy. Herein, aging or matched young mice were overexpressed with FNDC5 by adeno‐associated virus serotype 9 (AAV9) vectors, subcutaneously infused irisin to uncover role dysfunction. To verify involvement nucleotide‐binding oligomerization domain‐like receptor pyrin domain 3 (NLRP3) AMP‐activated protein kinase α (AMPKα), Nlrp3 Ampkα2 global knockout used. Besides, injected AAV9‐FNDC5 maintained 12 months determine preventive effect FNDC5. Moreover, neonatal rat cardiomyocytes stimulated tumor necrosis factor‐α (TNF‐α) examine vitro . We found that was downregulated hearts. Cardiac‐specific overexpression infusion significantly suppressed NLRP3 inflammasome inflammation, thereby attenuating remodeling In addition, treatment also inhibited cellular senescence TNF‐α‐stimulated Mechanistically, activated AMPKα through blocking lysosomal degradation glucagon‐like peptide‐1 receptor. More importantly, gene transfer early life could delay onset during process. prove improves activating AMPKα, it might be promising therapeutic target support health
Язык: Английский
Процитировано
67
Ageing Research Reviews, Год журнала: 2022, Номер 80, С. 101680 - 101680
Опубликована: Июль 3, 2022
Язык: Английский
Процитировано
54
Free Radical Biology and Medicine, Год журнала: 2023, Номер 201, С. 98 - 110
Опубликована: Март 20, 2023
Язык: Английский
Процитировано
23
Cells, Год журнала: 2024, Номер 13(3), С. 277 - 277
Опубликована: Фев. 2, 2024
Disorders of cardiomyocyte metabolism play a crucial role in many cardiovascular diseases, such as myocardial infarction, heart failure and ischemia–reperfusion injury. In is regulated by mitochondrial changes biogenesis, which allows energy homeostasis. There are proteins cells that regulate control metabolic processes. One them irisin (Ir), released from the transmembrane protein FNDC5. Initial studies indicated Ir myokine secreted mainly skeletal muscles. Further showed was also present various tissues. However, its highest levels were observed cardiomyocytes. responsible for processes, including conversion white adipose tissue (WAT) to brown (BAT) increasing expression thermogenin (UCP1). addition, affects biogenesis. Therefore, FNDC5/Ir blood myocardium may be important disease. This review discusses current knowledge about
Язык: Английский
Процитировано
11
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 171, С. 116007 - 116007
Опубликована: Янв. 3, 2024
Diabetic cardiomyopathy (DCM) is a common complication of diabetes mellitus (DM). However, the mechanisms underlying DCM-induced cardiac injury remain unclear. Recently, role cyclic GMP-AMP synthase/stimulator interferon gene (cGAS/STING) signaling and pyroptosis in DCM has been investigated. Based on our previous results, this study was designed to examine impact irisin, mitochondrial ubiquitin ligase (MITOL/MARCH5), cGAS/STING dysfunction effect gasdermin D (GSDMD)-dependent pyroptosis. High-fat diet-induced mice H9c2 cells were used for geometry function or pyroptosis-related biomarker assessment at end experiments. Here, we show that impairs by increasing fibrosis GSDMD-dependent pyroptosis, including activation MITOL signaling. Our results confirmed protective irisin partially offset We also demonstrated plays pivotal pathological process pathogenesis. indicate treatment protects against injury, homeostasis, through upregulation.
Язык: Английский
Процитировано
8