Physiological Reports,
Год журнала:
2025,
Номер
13(8)
Опубликована: Апрель 1, 2025
Abstract
Interleukin‐6
(IL‐6),
tumor
necrosis
factor
alpha
(TNF‐α),
and
irisin
(cytokines)
are
affected
by
excess
body
fat
(obesity),
skeletal
muscle,
resistance
exercise
(RE).
The
purpose
of
this
study
is
to
determine
whether
Prader‐Willi
Syndrome
(PWS),
a
genetic
cause
for
obesity
(OB),
or
non‐syndromic
OB
influences
these
cytokine
responses
RE.
Nine
children
with
PWS
(11.4
±
3.3
years,
45.6
5.2%
BF),
11
without
(9.2
1.4
18.6
5.0%
12
(9.6
1.3
40.4
5.4%
BF)
participated.
Children
stepped
onto
an
elevated
platform
wearing
weighted
vest
6
sets
10
repetitions
per
leg
separated
1
min
rest.
Blood
samples
were
obtained
before
(pre),
immediately
post
(IP),
during
recovery
(+15
+60
min).
There
no
group‐by‐time
interactions
any
cytokine;
neither
time
nor
group
effects
TNF‐α
(
p
≥
0.378).
For
IL‐6,
60+
was
higher
than
pre,
IP,
+15
<
0.001).
had
increased
IL‐6
≤
0.038).
Neither
However,
associated
concentrations.
Cell Death and Disease,
Год журнала:
2025,
Номер
16(1)
Опубликована: Фев. 3, 2025
Abstract
Prion
diseases
are
a
group
of
fatal
neurodegenerative
disorders
characterized
by
the
abnormal
folding
cellular
prion
proteins
into
pathogenic
forms.
The
development
these
is
intricately
linked
to
oxidative
stress
and
mitochondrial
dysfunction.
Irisin,
an
endogenous
myokine,
has
demonstrated
considerable
neuroprotective
potential
due
its
antioxidative
properties.
However,
protective
effects
irisin
against
have
yet
be
clarified.
Our
findings
indicate
that
treatment
with
exogenous
can
mitigate
apoptosis
induced
PrP
106–126.
Additionally,
significantly
reduces
alleviates
dysfunction
triggered
106–126
.
Furthermore,
targets
uncoupling
protein
2
(UCP2)
activates
AMPK-Nrf2
pathway,
substantially
improving
in
N2a
cells
These
results
suggest
represents
novel
promising
therapeutic
approach
for
treating
diseases.
Journal of Men s Health,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
This
study
was
aimed
to
investigate
the
effects
of
acute
and
chronic
High
Intensity
Interval
Training
(HIIT)
on
Irisin,
BDNF
(brain-derived
neurotrophic
factor),
Apelin
levels.
The
included
twenty-one
male
soccer
referees.
Blood
from
participants
collected
at
beginning
(1.
first
measurement:
baseline
value).
HIIT
conducted
blood
immediately
(2.
second
effect).
Next,
carried
out
for
20
minutes
4
days
a
week
in
bouts
running
(75
meters
seconds)
walking
(25
seconds).
end
12
weeks
(3.
third
performed
again
(4.
fourth
effect
after
There
gradual
increase
irisin,
BDNF,
apelin
levels
(p
<
0.001).
irisin
2%
measurement,
106%
third,
111%
compared
measurement.
39%
116%
133%
fourth.
were
increased
by
11%,
19%and
28%,
respectively.
These
results
demonstrated
that
might
only
response
(4
times
week)
while
change
with
both
healthy
trained
Journal of Advanced Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 1, 2024
Obesity-induced
bone
loss
affects
the
life
quality
of
patients
all
over
world.
Irisin,
one
myokines,
plays
an
essential
role
in
and
fat
metabolism.
Investigate
effects
irisin
on
metabolism
via
adipocytes
marrow
microenvironment.
In
this
study,
we
fed
fibronectin
type
III
domain-containing
protein
5
(FNDC5,
precursor
irisin)
knockout
mice
(FNDC5-/-)
with
a
high-fat
diet
(HFD)
for
10
weeks.
The
mass
was
assessed
by
micro-CT
analysis,
histological
staining,
dynamic
formation.
vitro,
lipogenic
differentiation
mesenchymal
stem
cells
(BMSCs)
assayed
Oil
Red
O
osteogenic
alkaline
phosphatase
staining.
Meanwhile,
gene
expression
BMSC-differentiated
RNA
sequence
involved
pathway
were
determined
western
blot
qRT-PCR
performed.
FNDC5-/-
HFD
showed
increased
body
weight,
content
bone,
decreased
formation
compared
those
standard
(SD).
inhibited
BMSCs
into
alleviated
inhibition
osteogenesis
derived
from
adipocyte
supernatant.
blocking
experiment
that
reduced
production
interleukin
6
(IL-6)
through
downregulating
TLR4/MyD88/NF-κB
pathway.
Immunofluorescence
staining
further
confirmed
IL-6
SD,
which
suffered
serious
loss.
Irisin
downregulates
activation
pathway,
thereby
reducing
to
enhance
BMSCs.
Thus,
rescue
BMSCs,
initially
IL-6,
is
potential
therapeutic
target
mitigate
obesity-induced
osteoporosis.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(7), С. 3605 - 3605
Опубликована: Март 23, 2024
Diabetic
nephropathy
(DN)
is
a
serious
complication
of
diabetes,
and
its
progression
influenced
by
factors
like
oxidative
stress,
inflammation,
cell
death,
fibrosis.
Compared
to
drug
treatment,
exercise
offers
cost-effective
low-risk
approach
slowing
down
DN
progression.
Through
multiple
ways
mechanisms,
helps
control
blood
sugar
pressure
reduce
serum
creatinine
albuminuria,
thereby
alleviating
kidney
damage.
This
review
explores
the
beneficial
effects
on
improvement
highlights
potential
mechanisms
for
ameliorating
DN.
In-depth
understanding
role
mechanism
in
improving
would
pave
way
formulating
safe
effective
programs
treatment
prevention
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Ноя. 24, 2023
Over
the
last
decade,
a
considerable
amount
of
new
data
have
revealed
beneficial
effects
exercise
on
hippocampal
neurogenesis
and
maintenance
or
improvement
cognitive
function.
Investigations
with
animal
models,
as
well
human
studies,
yielded
novel
understanding
mechanisms
through
which
endocrine
signaling
can
stimulate
neurogenesis,
acute
and/or
chronic
levels
these
circulating
hormones.
Considering
aging
decline
specific
factors
that
affect
brain
health,
insights
in
this
area
research
are
particularly
important.
In
review,
we
discuss
how
different
forms
influence
peripheral
production
factors,
particular
emphasis
brain-derived
neurotrophic
factor,
growth
hormone,
insulin-like
factor-1,
ghrelin,
estrogen,
testosterone,
irisin,
vascular
endothelial
erythropoietin,
cortisol.
We
also
describe
responses
to
induce
cellular
changes
increase
improve
Frontiers in Physiology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 9, 2024
Hamstring
muscles
are
most
affected
by
multiple
sprint-based
sports
as
a
result
of
muscle
strain
during
sprinting,
leading
to
reduced
performance
and
increased
risk
injury.
Therefore,
the
purpose
study
was
assess
inter-individual
variability
in
hamstrings
recovery
after
sport-specific
repeated-sprint
training
(RST),
through
sprint-specific
markers
associated
damage
biomarkers
women
men.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(18), С. 10116 - 10116
Опубликована: Сен. 20, 2024
Irisin,
a
myokine
derived
from
fibronectin
type
III
domain-containing
5
(FNDC5),
is
increasingly
recognized
for
its
protective
role
in
musculoskeletal
health
through
the
modulation
of
mitochondrial
quality
control.
This
review
synthesizes
current
understanding
irisin’s
impact
on
biogenesis,
dynamics,
and
autophagy
skeletal
muscle,
elucidating
capacity
to
bolster
muscle
strength,
endurance,
resilience
against
oxidative-stress-induced
atrophy.
The
multifunctional
nature
irisin
extends
bone
metabolism,
where
it
promotes
osteoblast
proliferation
differentiation,
offering
potential
intervention
osteoporosis
other
disorders.
Mitochondrial
control
vital
cellular
particularly
energy-demanding
tissues.
Irisin’s
influence
this
process
highlighted,
suggesting
integral
maintaining
homeostasis.
also
touches
upon
regulatory
mechanisms
secretion,
predominantly
induced
by
exercise,
systemic
effects
as
an
endocrine
factor.
While
therapeutic
promising,
need
standardized
measurement
techniques
further
elucidation
humans
acknowledged.
collective
findings
underscore
burgeoning
interest
keystone
candidate
future
strategies.
