Epstein-Barr virus as a cause of multiple sclerosis: opportunities for prevention and therapy

The Lancet Neurology, Год журнала: 2023, Номер 22(4), С. 338 - 349

Опубликована: Фев. 7, 2023

Язык: Английский

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The effects of intermittent fasting for patients with multiple sclerosis (MS): a systematic review

Frontiers in Nutrition, Год журнала: 2024, Номер 10

Опубликована: Янв. 17, 2024

Some studies have investigated the impact of intermittent fasting (IF) for patients with multiple sclerosis (MS). We aimed to conduct a comprehensive systematic review analyze and summarize all clinical concerning effects IF on MS. conducted an exhaustive information available in Embase, Cochrane, PubMed databases up until 1 September 2023. All research relating impacts MS were included. In total, this encompassed 5 studies, which included four RCTs one pilot study. Each study involved was assessed high quality. The results from these demonstrate that protocols could potentially serve as effective dietary strategy managing symptoms improving quality life individuals afflicted conclusion, might be potential beneficial intervention However, number trials field is relatively limited. large-scale investigate are urgently needed, may helpful manage intricate neuroimmune disorder. Systematic registration https://inplasy.com , identifier INPLASY2023100021.

Язык: Английский

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Efficacy and safety of mesenchymal stromal cell transplantation in the treatment of autoimmune and rheumatic immune diseases: a systematic review and meta-analysis of randomized controlled trials

Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 11, 2025

This study aims to assess the effectiveness and safety of mesenchymal stem cell (MSC) transplantation in treatment autoimmune rheumatic immune diseases through randomized controlled trials (RCTs). Two researchers conducted a comprehensive search Chinese English databases from their inception until Dec. 2023. The literature screening data extraction were then performed. Statistical analysis was carried out using RevMan 5.4 software. A total 42 relevant RCTs, involving 2,183 participants, ultimately included this study. These RCTs encompassed four types bone diseases, namely rheumatoid arthritis (RA), osteoarthritis (OA), spondyloarthritis, systemic sclerosis arthritis, lupus erythematosus (SLE), inflammatory bowel disease, multiple sclerosis, primary Sjögren's syndrome (PSS). systematic review indicates that MSC may improve RA, PSS. meta-analysis reveals significantly improved symptoms patients with OA [VAS (visual analogue scale): marrow: SMD = − 0.95, 95% CI 1.55 0.36, P 0.002; umbilical cord: 1.25, 2.04 0.46, adipose tissue: -1.26, -1.99 0.52, 0.0009)], SLE [Systemic disease activity index (SLEDAI): 2.32, 3.59 1.06, 0.0003], [clinical efficacy: RR 2.02, 1.53 2.67, < 0.00001]. However, not (Ssc). Importantly, did increase incidence adverse events (OA: 1.23, 0.93 1.65, 0.15; SLE: 0.83, 0.28 2.51, 0.76; Inflammatory disease: 0.99, 0.81 1.22, 0.96; Multiple sclerosis: 1.12, 1.53, 0.50), supporting its profile across studies. findings suggest holds promise for several while highlighting areas where further research is warranted. have potential treat diseases. Moreover. appears be relatively safe could considered as viable alternative option

Язык: Английский

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The Role of Gut Microbiome in the Pathogenesis of Multiple Sclerosis and Related Disorders

Cells, Год журнала: 2023, Номер 12(13), С. 1760 - 1760

Опубликована: Июнь 30, 2023

Multiple sclerosis (MS) is a chronic, progressive neuroinflammatory disease with complex pathophysiological background. A variety of diverse factors have been attributed to the propagation inflammation and neurodegeneration in MS, mainly genetic, immunological, environmental such as vitamin D deficiency, infections, or hormonal disbalance. Recently, importance gut-brain axis for development many neurological conditions, including stroke, movement disorders, has postulated. The purpose our paper was summarize current evidence confirming role gut microbiome pathophysiology MS related neuromyelitis optica spectrum disorder (NMO-SD). For this aim, we conducted systematic review literature listed following databases: Medline, Pubmed, Scopus, were able identify several studies demonstrating involvement NMO-SD. It seems that most relevant bacteria are those belonging Pseudomonas, Mycoplasma, Haemophilus, Blautia, Dorea, Faecalibacterium, Methanobrevibacter, Akkermansia, Desulfovibrionaceae genera, while Clostridium perfringens Streptoccocus demonstrated play Following line evidence, there also some preliminary data supporting use probiotics other agents affecting could potentially beneficial effect on MS/NMO-SD symptoms prognosis. topic therefore since it be used biomarker progression well potential disease-modifying therapy.

Язык: Английский

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Immunopathogenesis of multiple sclerosis: molecular and cellular mechanisms and new immunotherapeutic approaches

Immunopharmacology and Immunotoxicology, Год журнала: 2024, Номер 46(3), С. 355 - 377

Опубликована: Апрель 18, 2024

Background: Multiple sclerosis (MS) is a central nervous system (CNS) demyelinating autoimmune disease with increasing global prevalence. It predominantly affects females, especially those of European descent. The interplay between environmental factors and genetic predisposition plays crucial role in MS etiopathogenesis.

Язык: Английский

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Revolutionizing adjuvant development: harnessing AI for next-generation cancer vaccines

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Авг. 14, 2024

With the COVID-19 pandemic, importance of vaccines has been widely recognized and led to increased research development efforts. Vaccines also play a crucial role in cancer treatment by activating immune system target destroy cells. However, enhancing efficacy remains challenge. Adjuvants, which enhance response antigens improve vaccine effectiveness, have faced limitations recent years, resulting few novel adjuvants being identified. The advancement artificial intelligence (AI) technology drug provided foundation for adjuvant screening application, leading diversification adjuvants. This article reviews significant tumor basic clinical explores use AI screen from databases. findings this review offer valuable insights new next-generation vaccines.

Язык: Английский

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Endogenous retroviruses in multiple sclerosis: A network-based etiopathogenic model

Ageing Research Reviews, Год журнала: 2024, Номер 99, С. 102392 - 102392

Опубликована: Июнь 24, 2024

The present perspective article proposes an etiopathological model for multiple sclerosis pathogenesis and progression associated with the activation of human endogenous retroviruses. We reviewed preclinical, clinical, epidemiological, evolutionary evidence indicating how complex, multi-level interplay genetic traits environmental factors contributes to sclerosis. propose that in this process, retroviruses transactivation acts as a critical node disease development. also discuss rationale combined anti-retroviral therapy disease-modifying therapeutic strategy. Finally, we immuno-pathogenic process triggered by retrovirus can be extended aging aging-related neurodegeneration. In regard, envisioned act epigenetic noise, favoring proliferation disorganized cellular subpopulations accelerating system-specific "aging". Since inflammation are two sides same coin (plastic dis-adaptation external stimuli degree freedom), conditions may epiphenomenal products increased epigenomic entropy. Inflammation accelerates organ-specific aging, disrupting communication throughout systems body producing symptoms. Overlapping neurological symptoms syndromes emerge from activity shared molecular networks respond retroviruses' reactivation.

Язык: Английский

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Acupoint catgut embedding alleviates experimental autoimmune encephalomyelitis by modulating neuroinflammation and potentially inhibiting glia activation through JNK and ERK pathways

Frontiers in Neuroscience, Год журнала: 2025, Номер 18

Опубликована: Янв. 9, 2025

Acupoint catgut embedding (ACE) is a traditional Chinese medicine technique commonly used for managing various disorders, including chronic inflammatory pain and allergic asthma. Despite its growing use, the neuroimmunological mechanisms underlying ACE treatment effects remain unclear. This study investigated roles potential of in treating experimental autoimmune encephalomyelitis (EAE), frequently animal model neuroinflammation. The were evaluated by monitoring body weight EAE severity scores. Behavioral tests, histopathological analysis, ELISA, flow cytometry conducted to assess therapeutic efficacy ACE. RNA sequencing was performed uncover ACE-associated transcriptional signatures spinal cords mice. results validated through western blotting, qRT-PCR, immunofluorescence (IF) staining. In ACE-treated mice, disease significantly ameliorated, along with improvements anxiety-like behaviors reduced inflammation demyelination. restored immune imbalance mice decreasing Th17 Th1 cells, while increasing Treg cells peripheral organs reducing serum cytokine levels. revealed significant suppression genes pathways associated reactive microglial astrocytic activation, corroborated IF studies. Additionally, could suppress ERK JNK signaling at both protein These findings confirm protective role mitigating symptoms modulating activity regulating cytokines.

Язык: Английский

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Investigating causal associations between pork intake and multiple sclerosis using Mendelian randomization: Insights from large-scale GWAS data in European populations

Nutrition and Health, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Background Observational studies propose associations between dietary factors and multiple sclerosis (MS). However, the causal nature of these relationships remains unclear. This study aims to determine whether nutritional causally influence MS risk through Mendelian randomization (MR) analysis. Methods Summary statistics for 15 common were derived from Genome-Wide Association Study (GWAS) conducted by Medical Research Council Integrated Epidemiology Unit (MRC-IEU). The GWAS data sourced International Multiple Sclerosis Genetics Consortium (IMSGC), including 14,498 cases 24,091 controls. inverse-variance weighted (IVW) method was utilized as primary analytical approach estimate causality, while Cochran's Q test assessed heterogeneity. MR-Egger (MRE) MR-Pleiotropy RESidual Sum Outlier (MR-PRESSO) employed detect pleiotropy conduct sensitivity analyses. Results We executed univariable- multivariable-adjusted MR analyses, incorporating adjustments past tobacco smoking, particulate matter air pollution (PM2.5) moderate vigorous physical activity. univariable (UVMR) analysis elucidated potential concerning only two factors: pork intake (odds ratio [OR] = 6.764, 95% confidence interval [CI]: 1.772–25.814, p 0.005 IVW) fish/liver oil supplements (OR 0.119, 95%CI: 0.032–0.444, 0.002 IVW). In multivariate (MVMR) analysis, significant relationship remained robust even after adjusting confounders. Conversely, confounders, initially observed ceased be statistically significant. Conclusions Our findings suggest that could increase MS. Other analyzed in this did not exhibit correlations with

Язык: Английский

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Machine Learning Methods for Classifying Multiple Sclerosis and Alzheimer’s Disease Using Genomic Data

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 2085 - 2085

Опубликована: Фев. 27, 2025

Complex diseases pose challenges in prediction due to their multifactorial and polygenic nature. This study employed machine learning (ML) analyze genomic data from the UK Biobank, aiming predict predisposition complex like multiple sclerosis (MS) Alzheimer's disease (AD). We tested logistic regression (LR), ensemble tree methods, deep models for this purpose. LR displayed remarkable stability across various subsets of data, outshining approaches, which showed greater variability performance. Additionally, ML methods demonstrated an ability maintain optimal performance despite correlated features linkage disequilibrium. When comparing risk score (PRS) with PRS consistently performed at average level. By employing explainability tools MS, we found that results confirmed polygenicity disease. The highest-prioritized variants MS were identified as expression or splicing quantitative trait loci located non-coding regions within near genes associated immune response, a prevalence human leukocyte antigen (HLA) gene annotations. Our findings shed light on both potential capture patterns, paving way improved predictive models.

Язык: Английский

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