Psychological Medicine,
Год журнала:
2024,
Номер
unknown, С. 1 - 14
Опубликована: Дек. 16, 2024
Both
childhood
adversity
(CA)
and
first-episode
psychosis
(FEP)
have
been
linked
to
alterations
in
cortical
thickness
(CT).
The
interactive
effects
between
different
types
of
CAs
FEP
on
CT
remain
understudied.
One-hundred
sixteen
individuals
with
(mean
age
=
23.8
±
6.9
years,
34%
females,
80.2%
non-affective
FEP)
98
healthy
controls
(HCs)
24.4
6.2
43%
females)
reported
the
presence/absence
CA
<17
years
using
an
adapted
version
Childhood
Experience
Care
Abuse
(CECA.Q)
Retrospective
Bullying
Questionnaire
(RBQ)
underwent
magnetic
resonance
imaging
(MRI)
scans.
Correlation
analyses
were
used
assess
associations
brain
maps
effects.
General
linear
models
(GLMs)
performed
interaction
CT.
Eighty-three
83
HCs
exposure
at
least
one
CA.
similar
those
found
participants
exposed
separation
from
parents,
bullying,
parental
discord,
household
poverty,
sexual
abuse
(r
0.50
0.25).
Exposure
neglect
(β
-0.24,
95%
CI
[-0.37
-0.12],
p
0.016)
overall
maltreatment
-0.13,
[-0.20
-0.06],
0.043)
associated
thinning
right
medial
orbitofrontal
region.
Cortical
are
observed
context
socio-environmental
adversity.
Neglect
may
contribute
reductions
FEP.
Our
findings
provide
new
insights
into
specific
neurobiological
early
psychosis.
Psychological Medicine,
Год журнала:
2024,
Номер
54(11), С. 3099 - 3108
Опубликована: Май 30, 2024
Abstract
Background
Evidence
suggests
a
possible
relationship
between
exposure
to
childhood
adversity
(CA)
and
functional
impairment
in
psychosis.
However,
the
impact
of
CA
on
long-term
outcomes
psychotic
disorders
remains
poorly
understood.
Methods
Two
hundred
forty-three
patients
were
assessed
at
their
first
episode
psychosis
for
re-assessed
after
mean
21
years
follow-up
several
outcome
domains,
including
symptoms,
functioning,
quality
life,
cognitive
performance,
neurological
dysfunction,
comorbidity.
The
unique
predictive
ability
was
examined
using
linear
regression
analysis
controlling
relevant
confounders,
socioeconomic
status,
family
risk
schizophrenia,
obstetric
complications.
Results
There
54%
with
documented
history
mild
or
higher
levels.
experiences
more
prevalent
severe
schizophrenia
than
other
(
p
<
0.001).
Large
very
large
effect
sizes
observed
predicting
most
role
functioning
variables
negative
symptoms
(Δ
R
2
0.105
0.181).
Moderate
positive
personal
impaired
social
cognition,
immediate
verbal
learning,
poor
global
internalized
stigma,
recovery,
drug
abuse
severity
0.040
0.066).
A
dose–response
levels
domains.
Conclusion
Our
results
suggest
strong
widespread
link
early
disorders.
Awareness
serious
consequences
should
encourage
better
identification
those
development
effective
interventions.
Summary
Onyeama
et
al
have
examined
the
clinical
profile
of
individuals
with
psychosis
and
childhood
trauma
using
a
stringent
approach
that
yielded
selective
evidence,
affecting
power
insight
into
specific
differential
roles
abuse
neglect
in
profile.
This
commentary
puts
findings
broader
meta-analytical
context.
Schizophrenia Bulletin,
Год журнала:
2024,
Номер
50(5), С. 1055 - 1066
Опубликована: Май 30, 2024
Abstract
Background
During
the
last
decades,
an
abundance
of
studies
has
investigated
childhood
adversity
in
relation
to
psychosis.
This
systematic
review
critically
examines
methodologies
employed
investigate
psychosis
over
past
decade,
including
operational
definitions,
measurement
tools
and
characteristics,
psychometric
properties
instruments
used
these
studies.
Study
Design
followed
PRISMA
guidelines
(registration
number
CRD42022307096),
search
following
electronic
databases:
PsychINFO,
SCOPUS,
Web
Science,
African
Index
Medicus
(AIM),
LILACS,
CINAHL,
EMBASE,
MEDLINE.
The
included
variations
combinations
terms
targeting
Results
Out
585
identified
published
between
2010
2023,
341
a
validated
instrument
adversity.
Our
findings
show
“childhood
trauma”
being
most
frequently
examined
construct,
by
“child
maltreatment”
or
abuse.”
short
version
Childhood
Trauma
Questionnaire
was
dominant
instrument.
Physical
abuse,
emotional
sexual
abuse
were
investigated,
indeed
field
appears
generally
focus
on
child
neglect
other
adversities.
Significant
heterogeneity
observed
selection
summarization
items,
with
only
59%
documenting
original
validation
22%
reporting
reliability
their
datasets.
Conclusion
highlights
substantial
methodological
field,
pointing
out
biases
research
These
underline
need
for
standardized
definitions
high-quality
enhance
validity
future
this
area.
European journal of psychotraumatology,
Год журнала:
2023,
Номер
14(2)
Опубликована: Ноя. 23, 2023
Although
child
maltreatment
(CM)
has
been
linked
to
health
problems
and
poor
psychosocial
functioning,
not
all
individuals
exposed
CM
develop
or
experience
negative
consequences
later
in
life.
This
suggests
that
some
show
resilience
after
being
CM.
However,
conclusions
have
limited
by
inconsistent
findings
across
different
subtypes
domains.
Frontiers in Psychology,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 17, 2024
Childhood
trauma
can
have
negative
effects
on
several
domains
of
mental
functioning,
including
Autobiographical
Memory
(AM).
Conflicting
results
emerge
in
the
scientific
literature
regarding
childhood
AM.
In
this
review,
we
explored
relationship
between
and
AM,
classifying
as
interpersonal,
non-interpersonal
overall
(interpersonal
non-interpersonal).
We
carried
out
a
systematic
following
guidelines
Preferred
Reporting
Items
for
Systematic
Reviews
Meta-analyses
(PRISMA
statement).
From
searching
PubMed,
Scopus,
Web
Science
databases,
identified
48
studies
conducted
from
2014
to
2023,
which
were
included
when
they:
(a)
written
English,
(b)
investigated
AM
trauma,
(c)
sample
children,
adolescents,
or
adults
who
had
experienced
interpersonal
and/or
trauma.
Of
eligible
studies,
29
referred
an
nature,
12
7
Regarding
24
found
AM;
among
articles
10
no
relevant
relationship;
4
The
our
review
supports
prevalence
This
is
present
regardless
psychiatric
disorders
(e.g.,
Depression,
Post
Traumatic
Stress
Disorder,
Personality
Disorders),
presence
latter,
even
more
fragmented.
Future
research
should
use
accurate
methodologies
identifying
order
precisely
determine
its
effect
