Triangulating the associations of different types of childhood adversity and first-episode psychosis with cortical thickness across brain regions DOI Creative Commons
Natalia E. Fares‐Otero, Norma Verdolini, Helena Melero

et al.

Psychological Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 14

Published: Dec. 16, 2024

Both childhood adversity (CA) and first-episode psychosis (FEP) have been linked to alterations in cortical thickness (CT). The interactive effects between different types of CAs FEP on CT remain understudied. One-hundred sixteen individuals with (mean age = 23.8 ± 6.9 years, 34% females, 80.2% non-affective FEP) 98 healthy controls (HCs) 24.4 6.2 43% females) reported the presence/absence CA <17 years using an adapted version Childhood Experience Care Abuse (CECA.Q) Retrospective Bullying Questionnaire (RBQ) underwent magnetic resonance imaging (MRI) scans. Correlation analyses were used assess associations brain maps effects. General linear models (GLMs) performed interaction CT. Eighty-three 83 HCs exposure at least one CA. similar those found participants exposed separation from parents, bullying, parental discord, household poverty, sexual abuse (r 0.50 0.25). Exposure neglect (β -0.24, 95% CI [-0.37 -0.12], p 0.016) overall maltreatment -0.13, [-0.20 -0.06], 0.043) associated thinning right medial orbitofrontal region. Cortical are observed context socio-environmental adversity. Neglect may contribute reductions FEP. Our findings provide new insights into specific neurobiological early psychosis.

Language: Английский

Social cognition in maltreated individuals: Do type and timing of maltreatment matter? DOI
Natalia E. Fares‐Otero, Inga Schalinski

European Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 81, P. 38 - 40

Published: Feb. 6, 2024

Language: Английский

Citations

4
The association of adverse childhood experiences with long-term outcomes of psychosis: a 21-year prospective cohort study after a first episode of psychosis DOI
Víctor Peralta,

Elena García de Jalón,

Lucía Moreno-Izco

et al.

Psychological Medicine, Journal Year: 2024, Volume and Issue: 54(11), P. 3099 - 3108

Published: May 30, 2024

Abstract Background Evidence suggests a possible relationship between exposure to childhood adversity (CA) and functional impairment in psychosis. However, the impact of CA on long-term outcomes psychotic disorders remains poorly understood. Methods Two hundred forty-three patients were assessed at their first episode psychosis for re-assessed after mean 21 years follow-up several outcome domains, including symptoms, functioning, quality life, cognitive performance, neurological dysfunction, comorbidity. The unique predictive ability was examined using linear regression analysis controlling relevant confounders, socioeconomic status, family risk schizophrenia, obstetric complications. Results There 54% with documented history mild or higher levels. experiences more prevalent severe schizophrenia than other ( p < 0.001). Large very large effect sizes observed predicting most role functioning variables negative symptoms (Δ R 2 0.105 0.181). Moderate positive personal impaired social cognition, immediate verbal learning, poor global internalized stigma, recovery, drug abuse severity 0.040 0.066). A dose–response levels domains. Conclusion Our results suggest strong widespread link early disorders. Awareness serious consequences should encourage better identification those development effective interventions.

Language: Английский

Citations

4
A systematic review and meta-analysis of the traumatogenic phenotype hypothesis of psychosis: commentary, Alameda DOI Creative Commons
Luis Alameda

BJPsych Open, Journal Year: 2025, Volume and Issue: 11(2)

Published: March 1, 2025

Summary Onyeama et al have examined the clinical profile of individuals with psychosis and childhood trauma using a stringent approach that yielded selective evidence, affecting power insight into specific differential roles abuse neglect in profile. This commentary puts findings broader meta-analytical context.

Language: Английский

Citations

0
Associations Between Childhood Trauma and Social Cognition in Early Psychosis DOI

Daniela Cavero,

Raoul Jenni, Philippe Golay

et al.

Early Intervention in Psychiatry, Journal Year: 2025, Volume and Issue: 19(5)

Published: May 1, 2025

ABSTRACT Background Childhood trauma (CT), in the form of abuse and neglect, altered social cognition (SC) are both linked to poorer clinical functional outcomes psychosis. The impact CT its subtypes on SC early psychosis has been underexplored, with mixed findings from previous studies. current study investigated effects at‐risk mental state (ARMS) for first episode (FEP) individuals. Method One hundred seventeen individuals were included (ARMS [ n = 51], FEP 66]). History was assessed using composite score Trauma Questionnaire. abilities tested Reading Mind Eyes Test Theory (ToM) Emotion Expression Multimorph Task Recognition (ER). Linear regression, ANCOVA, repeated‐measures ANOVA performed investigate main interaction effects. Results significantly worse than ARMS participants ER sensitivity. Composite not associated either cohort. Physical neglect a strong predictor ToM ( 0.082). negatively overall sensitivity versus FEPs 0.079), particularly anger p < 0.001), disgust 0.019), sadness 0.004). Conclusion highlight importance investigating performance as specific may differentially SC. These associations can guide further investigation underlying mechanisms inform personalised interventions targeting deficits future research.

Language: Английский

Citations

0
How childhood adversities shape minds and lives: An analysis across the affective-to-psychotic spectrum DOI Creative Commons

Sophie-Kathrin Greiner,

Marco Pons,

Ayimnisagul Ablimit

et al.

Psychiatry Research, Journal Year: 2025, Volume and Issue: unknown, P. 116536 - 116536

Published: May 1, 2025

Language: Английский

Citations

0
Unraveling the Concept of Childhood Adversity in Psychosis Research: A Systematic Review DOI Creative Commons
Sjur Skjørshammer Sætren, Jone Bjørnestad, Akiah Ottesen Berg

et al.

Schizophrenia Bulletin, Journal Year: 2024, Volume and Issue: 50(5), P. 1055 - 1066

Published: May 30, 2024

Abstract Background During the last decades, an abundance of studies has investigated childhood adversity in relation to psychosis. This systematic review critically examines methodologies employed investigate psychosis over past decade, including operational definitions, measurement tools and characteristics, psychometric properties instruments used these studies. Study Design followed PRISMA guidelines (registration number CRD42022307096), search following electronic databases: PsychINFO, SCOPUS, Web Science, African Index Medicus (AIM), LILACS, CINAHL, EMBASE, MEDLINE. The included variations combinations terms targeting Results Out 585 identified published between 2010 2023, 341 a validated instrument adversity. Our findings show “childhood trauma” being most frequently examined construct, by “child maltreatment” or abuse.” short version Childhood Trauma Questionnaire was dominant instrument. Physical abuse, emotional sexual abuse were investigated, indeed field appears generally focus on child neglect other adversities. Significant heterogeneity observed selection summarization items, with only 59% documenting original validation 22% reporting reliability their datasets. Conclusion highlights substantial methodological field, pointing out biases research These underline need for standardized definitions high-quality enhance validity future this area.

Language: Английский

Citations

3
Pathways between childhood trauma, clinical symptoms, and functioning in new-onset psychosis: novel insights from a network analysis approach DOI Creative Commons

Dimitrios Kiakos,

Luis Alameda,

Inès Lepreux

et al.

Schizophrenia, Journal Year: 2025, Volume and Issue: 11(1)

Published: May 15, 2025

Abstract Childhood trauma (CT) has been linked to various domains of outcomes in individuals with new-onset psychosis, but the intricate relationships between different types trauma, clinical symptoms, and functioning remain poorly understood. The aim this study was identify patterns these three first-episode psychosis (FEP). sample consisted 277 patients from Treatment Early Intervention Psychosis Program (TIPP) at Lausanne University Hospital. Symptom severity assessed using Positive Negative Syndrome Scale (PANSS), evaluated an adapted version general subscale Premorbid Adjustment (PAS), five most common CT experiences (sexual, physical emotional abuse; neglect) measured a tailored questionnaire. Data early assessments (2 6 months after admission) were used for analysis. A network model fitted estimate shortest pathways linking functioning. Our findings revealed two distinct connecting One pathway influenced occupational through sexual abuse depression, while another affected socio-personal neglect stereotyped thinking. results suggest that disease phenotypes could be differentially associated psychosis. This contributes growing evidence supporting existence multiple each phenotype.

Language: Английский

Citations

0
Child maltreatment and resilience in adulthood: a protocol for a systematic review and meta-analysis DOI Creative Commons
Natalia E. Fares‐Otero,

O Jiaqing,

Georgina Spies

et al.

European journal of psychotraumatology, Journal Year: 2023, Volume and Issue: 14(2)

Published: Nov. 23, 2023

Although child maltreatment (CM) has been linked to health problems and poor psychosocial functioning, not all individuals exposed CM develop or experience negative consequences later in life. This suggests that some show resilience after being CM. However, conclusions have limited by inconsistent findings across different subtypes domains.

Language: Английский

Citations

8
Influence of the typology and timing of childhood trauma in psychoticism DOI

M Seguí-Grivé,

Nicolas Jurado,

Antonio María Lorca Navarrete

et al.

Archives of Women s Mental Health, Journal Year: 2024, Volume and Issue: 27(5), P. 705 - 719

Published: April 24, 2024

Language: Английский

Citations

2
The relationship between childhood interpersonal and non-interpersonal trauma and autobiographical memory: a systematic review DOI Creative Commons

Giovanni Borrelli,

Annachiara Lamberti Zanardi,

Claudia Scognamiglio

et al.

Frontiers in Psychology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 17, 2024

Childhood trauma can have negative effects on several domains of mental functioning, including Autobiographical Memory (AM). Conflicting results emerge in the scientific literature regarding childhood AM. In this review, we explored relationship between and AM, classifying as interpersonal, non-interpersonal overall (interpersonal non-interpersonal). We carried out a systematic following guidelines Preferred Reporting Items for Systematic Reviews Meta-analyses (PRISMA statement). From searching PubMed, Scopus, Web Science databases, identified 48 studies conducted from 2014 to 2023, which were included when they: (a) written English, (b) investigated AM trauma, (c) sample children, adolescents, or adults who had experienced interpersonal and/or trauma. Of eligible studies, 29 referred an nature, 12 7 Regarding 24 found AM; among articles 10 no relevant relationship; 4 The our review supports prevalence This is present regardless psychiatric disorders (e.g., Depression, Post Traumatic Stress Disorder, Personality Disorders), presence latter, even more fragmented. Future research should use accurate methodologies identifying order precisely determine its effect

Language: Английский

Citations

2