Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

Advanced Materials, Год журнала: 2021, Номер 33(22)

Опубликована: Апрель 19, 2021

Abstract Polyphenols, the phenolic hydroxyl group‐containing organic molecules, are widely found in natural plants and have shown beneficial effects on human health. Recently, polyphenol‐containing nanoparticles attracted extensive research attention due to their antioxidation property, anticancer activity, universal adherent affinity, thus great promise preparation, stabilization, modification of multifunctional nanoassemblies for bioimaging, therapeutic delivery, other biomedical applications. Additionally, metal−polyphenol networks, formed by coordination interactions between polyphenols metal ions, been used prepare an important class surface modification, drug disease treatments. By focusing different materials (e.g., inorganic materials, polymers, proteins, nucleic acids), a comprehensive review synthesis properties is provided. Moreover, remarkable versatility applications, including biodetection, multimodal protein gene bone repair, antibiosis, cancer theranostics also demonstrated. Finally, challenges faced future regarding discussed.

Язык: Английский

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Metal Ion-Directed Functional Metal–Phenolic Materials

Chemical Reviews, Год журнала: 2022, Номер 122(13), С. 11432 - 11473

Опубликована: Май 10, 2022

Metal ions are ubiquitous in nature and play significant roles assembling functional materials fields spanning chemistry, biology, science. Metal-phenolic assembled from phenolic components the presence of metal through formation metal-organic complexes. Alkali, alkali-earth, transition, noble as well metalloids interacting with building blocks have been widely exploited to generate diverse hybrid materials. Despite extensive studies on synthesis metal-phenolic materials, a comprehensive summary how guide assembly compounds is lacking. A fundamental understanding engineering will facilitate specific properties. In this review, we focus diversity function material emerging applications. Specifically, discuss range underlying interactions, including (i) cation-π, (ii) coordination, (iii) redox, (iv) dynamic covalent highlight wide properties resulting these interactions. Applications (e.g., biological, catalytic, environmental) perspectives also highlighted.

Язык: Английский

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Preparation and application of pH-responsive drug delivery systems

Journal of Controlled Release, Год журнала: 2022, Номер 348, С. 206 - 238

Опубликована: Июнь 8, 2022

Язык: Английский

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Phenolic-enabled nanotechnology: versatile particle engineering for biomedicine

Chemical Society Reviews, Год журнала: 2021, Номер 50(7), С. 4432 - 4483

Опубликована: Янв. 1, 2021

Phenolics are ubiquitous in nature and have gained immense research attention because of their unique physiochemical properties widespread industrial use. In recent decades, accessibility, versatile reactivity, relative biocompatibility catalysed phenolic-enabled nanotechnology (PEN) particularly for biomedical applications which been a major benefactor this emergence, as largely demonstrated by polydopamine polyphenols. Therefore, it is imperative to overveiw the fundamental mechanisms synthetic strategies PEN state-of-the-art provide timely comprehensive summary. review, we will focus on principles involved summarize use toolkit particle engineering bottom-up synthesis nanohybrid materials. Specifically, discuss attractive forces between phenolics complementary structural motifs confined systems synthesize high-quality products with controllable size, shape, composition, well surface chemistry function. Additionally, phenolic's numerous biosensing, bioimaging, disease treatment be highlighted. This review aims guidelines new scientists field serve an up-to-date compilation what has achieved area, while offering expert perspectives PEN's translational research.

Язык: Английский

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Engineering polyphenols with biological functions via polyphenol-protein interactions as additives for functional foods

Trends in Food Science & Technology, Год журнала: 2021, Номер 110, С. 470 - 482

Опубликована: Фев. 15, 2021

Язык: Английский

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Naturally sourced hydrogels: emerging fundamental materials for next-generation healthcare sensing

Chemical Society Reviews, Год журнала: 2023, Номер 52(9), С. 2992 - 3034

Опубликована: Янв. 1, 2023

The flourishing development of flexible healthcare sensing systems is inseparable from the fundamental materials with application-oriented mechanical and electrical properties. Thanks to continuous inspiration our Mother Nature, hydrogels originating natural biomass are attracting growing attention for their structural functional designs owing unique chemical, physical biological These highly efficient architectural enable them be most promising candidates electronic devices. This comprehensive review focuses on recent advances in naturally sourced constructing multi-functional sensors applications thereof. We first briefly introduce representative polymers, including polysaccharides, proteins, polypeptides, summarize physicochemical design principles fabrication strategies hydrogel based these polymers outlined after material properties required presented. then highlight various techniques devices, illustrate examples wearable or implantable bioelectronics pressure, strain, temperature, biomarker field systems. Finally, concluding remarks challenges prospects hydrogel-based provided. hope that this will provide valuable information next-generation build a bridge between as matter an applied target accelerate new near future.

Язык: Английский

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Infant Skin Friendly Adhesive Hydrogel Patch Activated at Body Temperature for Bioelectronics Securing and Diabetic Wound Healing

ACS Nano, Год журнала: 2022, Номер 16(6), С. 8662 - 8676

Опубликована: Май 13, 2022

Adhesive-caused injury is a great threat for infants with premature skin or diabetic patients fragile because extra-strong adhesion might incur pain, inflammation, and exacerbate trauma upon removal. Herein, we present skin-friendly adhesive hydrogel patch based on protein–polyphenol complexation strategy, which leads to thermoresponsive network sensitive body temperature. The of the smartly activated after contacting warm skin, whereas painless detachment easily realized by placing an ice bag surface hydrogel. exhibits immunomodulatory performance that prevents irritation allergic reactions during long-period contact skin. Thus, works as conformable nonirritating interface guarantee nondestructively securing bioelectronics infant healthcare. Furthermore, provides gentle wounded favorable environment speed up healing process managing wounds.

Язык: Английский

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Recent Advances in the Development and Antimicrobial Applications of Metal–Phenolic Networks

Advanced Science, Год журнала: 2022, Номер 9(27)

Опубликована: Июль 25, 2022

Due to the abuse of antibiotics and emergence multidrug resistant microorganisms, medical devices, related biomaterials are at high risk microbial infection during use, placing a heavy burden on patients healthcare systems. Metal-phenolic networks (MPNs), an emerging organic-inorganic hybrid network system developed gradually in recent years, have exhibited excellent multifunctional properties such as anti-inflammatory, antioxidant, antibacterial by making use coordination between phenolic ligands metal ions. Further, MPNs received widespread attention antimicrobial infections due their facile synthesis process, biocompatibility, brought about polyphenols In this review, different categories based (nanoparticles, coatings, capsules, hydrogels) fabrication strategies summarized, research advances applications biomedical fields (e.g., skin repair, bone regeneration, etc.) highlighted.

Язык: Английский

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Advances in tannic acid-incorporated biomaterials: Infection treatment, regenerative medicine, cancer therapy, and biosensing

Chemical Engineering Journal, Год журнала: 2021, Номер 432, С. 134146 - 134146

Опубликована: Дек. 29, 2021

Язык: Английский

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Versatile polyphenolic platforms in regulating cell biology

Chemical Society Reviews, Год журнала: 2022, Номер 51(10), С. 4175 - 4198

Опубликована: Янв. 1, 2022

Polyphenolic materials are a class of fascinating and versatile bioinspired for biointerfacial engineering. In particular, due to the presence active chemical groups, series unique physicochemical properties become accessible tunable as-prepared polyphenolic platforms, which could delicately regulate cell activities via cell-material contact-dependent interactions. More interestingly, polyphenols also affect behaviors contact-independent manner, arise their intrinsically functional characteristics (e.g., antioxidant photothermal behaviors). As such, comprehensive understanding on relationship between material desired biomedical applications, as well underlying mechanism at cellular molecular level would provide design principles accelerate lab-to-clinic translation platforms. this review, we firstly give brief overview hallmarks governed by surrounding cues, followed introduction engineering strategies. Subsequently, detailed discussion cell-polyphenols interfacial interaction was carefully provided. Lastly, applications were elaborated. We believe that review guidances rational multifunctional extend application window.

Язык: Английский

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