Thermal immuno-nanomedicine in cancer

Nature Reviews Clinical Oncology, Год журнала: 2023, Номер 20(2), С. 116 - 134

Опубликована: Янв. 5, 2023

Язык: Английский

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Nanocarriers based on bacterial membrane materials for cancer vaccine delivery

Nature Protocols, Год журнала: 2022, Номер 17(10), С. 2240 - 2274

Опубликована: Июль 25, 2022

Here we present a protocol for the construction and use of two types nanocarrier based on bacterial membrane materials cancer vaccine delivery. Cancer vaccines induce tumor regression through triggering specific T-cell responses against neoantigens, process that can be enhanced by Inspired body's natural immune defenses invasion, have developed different materials, which employ genetically engineered outer-membrane vesicles (OMVs), or hybrid containing cytoplasmic membrane, respectively. The OMV-based nanocarriers rapidly display antigens surface modified Plug-and-Display system, suitable customized when neoantigens identified. membrane-based are prepared fusion primary cell from surgically removed tissues, possessing unique advantages as personalized not readily available. Compared with chemically synthesized such liposomes polymer without intrinsic adjuvant properties, owing to large amounts pathogen-associated molecular patterns, activate antigen-presenting cells while delivering multiple antigens, thus inducing effective antigen presentation robust adaptive activation. Excluding culture tissue collection, preparation OMV- takes ~8 h 10 construction, We also detail how these create nanovaccines evaluate their immunostimulatory antitumor effects. This details in delivery nanovaccines.

Язык: Английский

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Nanovaccines with cell-derived components for cancer immunotherapy

Advanced Drug Delivery Reviews, Год журнала: 2022, Номер 182, С. 114107 - 114107

Опубликована: Янв. 4, 2022

Язык: Английский

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Conjugation of Macrophage-Mimetic Microalgae and Liposome for Antitumor Sonodynamic Immunotherapy via Hypoxia Alleviation and Autophagy Inhibition

ACS Nano, Год журнала: 2023, Номер 17(4), С. 4034 - 4049

Опубликована: Фев. 5, 2023

Sonodynamic therapy (SDT) is a noninvasive technique for local antitumor treatment; however, its clinical application often limited by the low tumor accumulation of SDT agents, tumor's hypoxic microenvironment, and cytoprotective effects autophagy. To address these issues, herein we developed surface-engineered chlorella (Chl, green algae) as targeted drug carrier sustainable oxygen supplier (via photosynthesis) significantly improved via hypoxia alleviation well autophagy inhibition chloroquine phosphate. In this design, macrophage membrane was coated onto Chl to form macrophage-mimetic (MChl) increase biocompatibility driven inflammatory-homing membranes. addition, coating on allowed lipid insertion yield β-cyclodextrin (β-CD) modified MChl (CD-MChl). Subsequently, supramolecular conjugates MChl-NP were constructed host–guest interactions between CD-MChl adamantane (ADA)-modified liposome (ADA-NP), anchored went with hand-in-hand tissues co-delivery Chl, hematoporphyrin, phosphate (loaded in ADA-NP). The synergistic achieved oxygenation, SDT, maximally therapeutic efficacy MChl-CQ-HP-NP against melanoma. Tumor rechallenging results revealed that changes microenvironment including alleviation, induced immunogenic cell death, collectively strong immune response memory.

Язык: Английский

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The advent of immune stimulating CAFs in cancer

Nature reviews. Cancer, Год журнала: 2023, Номер 23(4), С. 258 - 269

Опубликована: Фев. 17, 2023

Язык: Английский

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Nanomedicines and nanomaterials for cancer therapy: Progress, challenge and perspectives

Chemical Engineering Journal, Год журнала: 2022, Номер 446, С. 137147 - 137147

Опубликована: Май 24, 2022

Язык: Английский

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Strategies targeting PD-L1 expression and associated opportunities for cancer combination therapy

Theranostics, Год журнала: 2023, Номер 13(5), С. 1520 - 1544

Опубликована: Янв. 1, 2023

Immunotherapy has achieved great success recently and opened a new avenue for anti-tumor treatment. Programmed cell death 1/programmed ligand 1 (PD-1/PD-L1) are typical immune checkpoints that transmit coinhibitory signals, muting the host immunity. Monoclonal antibodies block PD-1/PD-L1 axis have benefited many patients with different tumor diseases. However, objective response rate is still unsatisfactory. In this review, we summarize three strategies targeting PD-L1 based on forms of various regulating mechanisms to enhance therapeutic effect, including blockade interaction between PD-1, downregulation expression degradation mature PD-L1. Thereinto, describe variety materials been designed target PD-L1, antibodies, nanoparticle, peptide, aptamer, RNA, small molecule. Additionally, list drugs regulation capacity used in clinical ongoing studies explore other alternatives besides anti-PD-L1 monoclonal antibodies. Moreover, discuss associated opportunities cancer combination therapy modalities such as chemotherapy, radiotherapy, photodynamic (PDT) photothermal (PTT), these conventional or emerging capable increasing cells by altering microenvironment (TME), would display synergistic effect. At last, give brief summary outlook regarding research status future prospect immunotherapy.

Язык: Английский

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Regulatory insights into nanomedicine and gene vaccine innovation: Safety assessment, challenges, and regulatory perspectives

Acta Biomaterialia, Год журнала: 2024, Номер 180, С. 1 - 17

Опубликована: Апрель 10, 2024

This analysis explores the principal regulatory concerns linked to nanomedicines and gene vaccines, including complexities involved perspectives on how navigate them. In realm of nanomedicines, ensuring safety nanomaterials is paramount due their unique characteristics potential interactions with biological systems. Regulatory bodies are actively formulating guidelines standards assess risks associated nanomedicine products, emphasizing need for standardized characterization techniques accurately gauge effectiveness. Regarding frameworks must be tailored address distinct challenges posed by genetic interventions, necessitating special considerations in efficacy evaluations, particularly concerning vector design, target specificity, long-term patient monitoring. Ethical such as autonomy, informed consent, privacy also demand careful attention, alongside intricate matter intellectual property rights, which balanced against imperative widespread access these life-saving treatments. Collaborative efforts among bodies, researchers, patent offices, private sector essential tackle effectively, international cooperation being especially crucial given global scope vaccine development. Striking right balance between safeguarding properties promoting public health vital fostering innovation equitable ground-breaking technologies, underscoring significance addressing hurdles fully harness benefits vaccines enhancing healthcare outcomes a scale. STATEMENT OF SIGNIFICANCE: Several biomaterials proposed development nanovaccines, from polymeric micelles, PLGA-/PEI-/PLL-nanoparticles, solid lipid nananoparticles, cationic lipoplexes, liposomes, hybrid materials, dendrimers, carbon nanotubes, hydrogels, quantum dots. Lipid nanoparticles (LNPs) have gained tremendous attention since US Food Drug Administration (FDA) approval Pfizer Moderna's COVID-19 raising awareness vaccines. review provides insights into current strategies issues, clinical trials. By navigating landscapes we can unlock full using range promising towards improving worldwide.

Язык: Английский

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Lymph-targeted high-density lipoprotein-mimetic nanovaccine for multi-antigenic personalized cancer immunotherapy

Science Advances, Год журнала: 2024, Номер 10(11)

Опубликована: Март 13, 2024

Cancer vaccines show huge potential for cancer prevention and treatment. However, their efficacy remains limited due to weak immunogenicity regarding inefficient stimulation of cytotoxic T lymphocyte (CTL) responses. Inspired by the unique characteristic biological function high-density lipoprotein (HDL), we here develop an HDL-mimicking nanovaccine with commendable lymph-targeted capacity potently elicit antitumor immunity using lipid nanoparticle that is co-loaded specific cytomembrane harboring a collection tumor-associated antigens immune adjuvant. The nanoparticulate impact explored on efficiency lymphatic targeting dendritic cell uptake. optimized promotes co-delivery adjuvants lymph nodes maintains antigen presentation cells, resulting in long-term surveillance as elevated frequency CTLs within lymphoid organs tumor tissue. Immunization suppresses formation growth augments therapeutic checkpoint inhibitors notably high-stemness melanoma mouse models.

Язык: Английский

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Nanoplatform-enhanced photodynamic therapy for the induction of immunogenic cell death

Journal of Controlled Release, Год журнала: 2024, Номер 365, С. 1058 - 1073

Опубликована: Янв. 1, 2024

Язык: Английский

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