Abstract
Nanomedicine‐assisted
sonodynamic
therapy
(SDT)
has
emerged
as
one
of
the
most
promising
cancer
therapies
due
to
its
unique
advantages
high
penetration,
non‐radiation,
and
excellent
oxidative
stress
effect,
but
always
suffered
from
self‐protection
mechanism
apoptosis
resistance
characteristics
evolutionarily
mutated
cells.
Regulated
cell
death
(RCD)
received
increasing
attention
in
precision
treatments
because
significant
role
synergistically
sensitizing
reversing
immunosuppressive
microenvironment
during
SDT
nanomedicine‐triggered
immunogenic
death.
Herein,
paradigmatic
research
RCD‐augmented
tumor
immunotherapeutics
are
typically
introduced,
such
autophagy
blockade,
ferroptosis
targeting,
pyroptosis
induction,
necroptosis
initiation,
cuproptosis
actuation,
PANoptosis
trigger,
coordinated
anti‐tumor
mechanisms
discussed
detail.
Multiple
analysis
focusing
on
currently
unsolved
problems
future
development
prospects
RCD‐based
nano‐oncology
medicine
also
prospected
further
strengthen
expand
scope
therapeutic
applications.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Март 11, 2023
Abstract
The
frequent
outbreak
of
global
infectious
diseases
has
prompted
the
development
rapid
and
effective
diagnostic
tools
for
early
screening
potential
patients
in
point-of-care
testing
scenarios.
With
advances
mobile
computing
power
microfluidic
technology,
smartphone-based
health
platform
drawn
significant
attention
from
researchers
developing
devices
that
integrate
optical
detection
with
artificial
intelligence
analysis.
In
this
article,
we
summarize
recent
progress
these
platforms,
including
aspects
chips,
imaging
modalities,
supporting
components,
software
algorithms.
We
document
application
platforms
terms
objects,
molecules,
viruses,
cells,
parasites.
Finally,
discuss
prospects
future
platforms.
Journal of Hematology & Oncology,
Год журнала:
2023,
Номер
16(1)
Опубликована: Июль 14, 2023
Early
detection
and
diagnosis
of
many
cancers
is
very
challenging.
Late
stage
a
cancer
always
leads
to
high
mortality
rates.
It
imperative
develop
novel
more
sensitive
effective
therapeutic
methods
for
treatments.
The
development
new
treatments
has
become
crucial
aspect
medical
advancements.
Nanobots,
as
one
the
most
promising
applications
nanomedicines,
are
at
forefront
multidisciplinary
research.
With
progress
nanotechnology,
nanobots
enable
assembly
deployment
functional
molecular/nanosized
machines
increasingly
being
utilized
in
treatment.
In
recent
years,
various
practical
have
transitioned
from
theory
practice,
vitro
experiments
vivo
applications.
this
paper,
we
review
analyze
advancements
treatments,
with
particular
emphasis
on
their
key
fundamental
features
drug
delivery,
tumor
sensing
diagnosis,
targeted
therapy,
minimally
invasive
surgery,
other
comprehensive
At
same
time,
discuss
challenges
potential
research
opportunities
revolutionizing
future,
expected
sophisticated
capable
performing
multiple
functions
tasks,
ultimately
becoming
true
nanosubmarines
bloodstream.
Nano-Micro Letters,
Год журнала:
2023,
Номер
15(1)
Опубликована: Фев. 8, 2023
Gene
therapy
provides
a
promising
approach
in
treating
cancers
with
high
efficacy
and
selectivity
few
adverse
effects.
Currently,
the
development
of
functional
vectors
safety
effectiveness
is
intense
focus
for
improving
delivery
nucleic
acid
drugs
gene
therapy.
For
this
purpose,
stimuli-responsive
nanocarriers
displayed
strong
potential
overall
efficiencies
reducing
effects
via
effective
protection,
prolonged
blood
circulation,
specific
tumor
accumulation,
controlled
release
profile
drugs.
Besides,
synergistic
could
be
achieved
when
combined
other
therapeutic
regimens.
This
review
summarizes
recent
advances
various
delivery.
Particularly,
responding
to
endogenous
stimuli
including
pH,
reactive
oxygen
species,
glutathione,
enzyme,
etc.,
exogenous
light,
thermo,
ultrasound,
magnetic
field,
are
introduced.
Finally,
future
challenges
prospects
toward
clinical
translation
well
discussed.
The
major
objective
present
biomedical
cancer
provide
guidance
developing
novel
nanoplatforms
that
clinically
applicable.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Авг. 12, 2024
Cancer
remains
a
significant
risk
to
human
health.
Nanomedicine
is
new
multidisciplinary
field
that
garnering
lot
of
interest
and
investigation.
shows
great
potential
for
cancer
diagnosis
treatment.
Specifically
engineered
nanoparticles
can
be
employed
as
contrast
agents
in
diagnostics
enable
high
sensitivity
high-resolution
tumor
detection
by
imaging
examinations.
Novel
approaches
labeling
are
also
made
possible
the
use
nanoprobes
nanobiosensors.
The
achievement
targeted
medication
delivery
therapy
accomplished
through
rational
design
manufacture
nanodrug
carriers.
Nanoparticles
have
capability
effectively
transport
medications
or
gene
fragments
tissues
via
passive
active
targeting
processes,
thus
enhancing
treatment
outcomes
while
minimizing
harm
healthy
tissues.
Simultaneously,
context
radiation
sensitization
photothermal
enhance
therapeutic
efficacy
malignant
tumors.
This
review
presents
literature
overview
summary
how
nanotechnology
used
According
oncological
diseases
originating
from
different
systems
body
combining
pathophysiological
features
cancers
at
sites,
we
most
recent
developments
applications.
Finally,
briefly
discuss
prospects
challenges
cancer.
ACS Nano,
Год журнала:
2023,
Номер
17(10), С. 9003 - 9013
Опубликована: Апрель 28, 2023
The
intelligent
responsive
drug
delivery
system
has
great
application
potential
in
cancer
precision
therapy.
Although
many
antitumor
methods
have
been
developed
based
on
systems,
most
of
them
yet
suffer
from
poor
efficiency.
In
this
project,
a
near-infrared
and
pH
dual-response
multimodal
collaborative
platform
for
diagnosis
treatment
(PCN-DOX@PDA)
was
constructed.
We
used
PCN-600
as
vehicle
loaded
with
antineoplastic
drugs
polydopamine
(PDA).
Under
633
nm
laser
irradiation,
the
ligand
tetrakis(4-carboxyphenyl)porphyrin
(TCPP)
can
generate
singlet
oxygen
(1O2)
kill
tumor
cells.
PDA
is
photothermal
agent
PTT.
PCN-DOX@PDA
achieves
release
by
responding
to
weak
acidity
microenvironment
thermal
stimulation
generated
NIR
irradiation.
addition,
since
central
ion
PCN
Fe3+,
realizes
tumors
through
magnetic
resonance
imaging-mediated
chemotherapy
photodynamic
synergistic
This
triple
strategy
showed
excellent
biocompatibility
ability
vivo
experiments
4T1
tumor-bearing
mouse
model,
indicating
that
good
development
prospect
field
therapy
diversified
biomedical
applications.
Metal-organic
framework
(MOF)-based
drug
delivery
systems
have
demonstrated
values
in
oncotherapy.
Current
research
endeavors
are
centralized
on
the
functionality
enrichment
of
featured
MOF
materials
with
designed
versatility
for
synergistic
multimodal
treatments.
Here,
inspired
by
multifarious
biological
functions
including
ferroptosis
pattern,
porphyrins,
and
cancer
cell
membrane
(CCM)
camouflage
technique,
novel
multi-biomimetic
nanocarriers
from
microfluidics
prepared.
The
Fe
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(5), С. 2643 - 2692
Опубликована: Янв. 1, 2024
This
review
discusses
the
structures
and
engineering
strategies
of
nanocatalysts,
highlighting
their
underlying
mechanisms
applications
in
cancer
immunotherapy.
