Environment & Health,
Год журнала:
2024,
Номер
2(11), С. 776 - 785
Опубликована: Авг. 16, 2024
Chlorinated
polyfluorinated
ether
sulfonate
(F-53B),
a
chromium-fog
depressant
widely
utilized
as
an
alternative
to
perfluorooctanesulfonate,
can
transfer
from
mother
fetus.
Recent
research
has
demonstrated
that
prenatal
exposure
F-53B
results
in
synaptic
damage
weaning
mice.
However,
the
mechanism
underpinning
F-53B-triggered
during
fetal
development
remains
unclear.
This
study
aims
investigate
role
of
protein
kinase
A
(PKA)/cAMP
response
element-binding
(CREB)
pathway,
crucial
signaling
known
"synaptic
switch",
early
neurotoxicity
both
vivo
and
vitro.
Here,
C57BL/6
mice
were
subjected
(0,
4,
40
μg/L)
gestation
days
(GD)
0
14
evaluate
nerve
injury
prior
delivery.
HT22
neurons
exposed
0.016,
0.08,
0.4,
2,
10
μmol/L)
for
24
h
elucidate
underlying
mechanism.
Our
significantly
increased
fluorescence
intensity
Nestin
(a
neural
stem
cell
marker)
brain
hippocampus
(GD14).
Subsequently,
we
found
downregulated
expression
plasticity
markers
(SYP,
GAP43,
BDNF)
neurons.
Further
molecular
docking
analysis
revealed
fits
into
ligand-binding
pockets
PKA
CREB1.
Results
showed
inhibited
translocation
cytoplasm
neuronal
nuclei
reduced
levels
PKA,
CREB1,
p-PKA(α/β/γ)-Thr197,
p-CREB1-S133
nucleus.
Furthermore,
altered
by
could
be
reversed
agonist
was
intensified
antagonist.
In
summary,
our
findings
suggest
intrauterine
weaken
brain,
with
this
being
mediated
cytoplasmic
retention
PKA.
Environmental Sciences Europe,
Год журнала:
2023,
Номер
35(1)
Опубликована: Март 23, 2023
Abstract
Background
Per-
and
polyfluorinated
alkyl
substances
(PFAS)
have
received
increasing
scientific
political
attention
in
recent
years.
Several
thousand
commercially
produced
compounds
are
used
numerous
products
technical
processes.
Due
to
their
extreme
persistence
the
environment,
humans
all
other
life
forms
are,
therefore,
increasingly
exposed
these
substances.
In
following
review,
PFAS
will
be
examined
comprehensively.
Results
The
best
studied
carboxylic
sulfonic
acids
with
chain
lengths
of
C4
C14,
particularly
perfluorooctanoic
acid
(PFOA)
perfluorooctane
(PFOS).
These
harmful
aquatic
fauna,
insects,
amphibians
at
concentrations
a
few
µg/L
or
less,
accumulate
organisms,
biomagnify
food
webs.
Humans,
as
final
link
chains,
subjected
uptake
primarily
through
drinking
water.
multiple
toxic
effects,
affecting
liver,
kidney,
thyroid,
immune
system.
latter
effect
is
basis
for
establishment
tolerable
weekly
dose
only
4.4
ng/kg
body
weight
sum
four
representatives
PFOA,
PFOS,
perfluorononanoic
(PFNA)
perfluorohexane
(PFHxS)
by
European
Food
Safety
Authority
(EFSA)
2020.
Exposure
estimates
human
biomonitoring
show
that
this
value
frequently
reached,
many
cases
exceeded.
major
challenge
analysis,
especially
waste:
single-substance
analyses
capture
fragment
large,
diverse
family
PFAS.
As
consequence,
parameters
gained
importance.
high
mobility
per
makes
soil
groundwater
pollution
contaminated
sites
problem.
general,
short-chain
more
mobile
than
long-chain
ones.
Processes
purification
water
treatment
often
ineffective
expensive.
Recycling
PFAS-containing
such
paper
packaging
leads
carryover
contaminants.
Incineration
requires
temperatures
completely
destroy
After
PFOS
perfluorinated
were
regulated
internationally,
manufacturers
users
switched
PFAS:
representatives,
per-
oxo
acids,
telomeric
alcohols
acids.
Analytical
studies
an
increase
environmental
chemicals.
Ultra-short
(chain
length
C1–C3)
not
been
well
studied.
Among
others,
trifluoroacetic
(TFA)
present
globally
rapidly
concentrations.
Conclusions
substitution
individual
recognized
hazardous
possibly
equally
virtually
unknown
chronic
toxicity
can,
solution.
answer
switch
fluorine-free
alternatives
applications
which
essential.
Environmental Science & Technology,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 11, 2024
Per-
and
polyfluoroalkyl
substances
(PFAS)
may
cause
various
deleterious
health
effects.
Epidemiological
studies
have
demonstrated
associations
between
PFAS
exposure
adverse
neurodevelopmental
outcomes.
The
cytotoxicity,
neurotoxicity,
mitochondrial
toxicity
of
up
to
12
including
perfluoroalkyl
carboxylates,
sulfonates,
6:2
fluorotelomer
sulfonic
acid
(6:2
FTSA),
hexafluoropropylene
oxide-dimer
(HPFO-DA)
were
tested
at
concentrations
typically
observed
in
the
environment
(e.g.,
wastewater,
biosolids)
human
blood
using
high-throughput
Environment International,
Год журнала:
2023,
Номер
176, С. 107977 - 107977
Опубликована: Май 15, 2023
Several
per-
and
polyfluoroalkyl
substances
(PFAS)
have
been
linked
to
metabolic
disorders
in
organisms.
However,
few
studies
considered
their
combined
effects,
which
would
be
more
representative
of
PFAS
occurring
the
environment.
In
this
study,
zebrafish
embryos
were
exposed
a
mixture
18
at
three
environmentally
relevant
concentrations
for
5
days
assess
bioconcentration
consequences.
The
burdens
∑PFAS
larvae
0.12,
1.58,
9.63
mg/kg
0.5,
5,
50
μg/L
treatment
groups,
respectively.
Exposure
accelerated
hatching
larval
heart
rates,
increased
energy
expenditure,
reduced
ATP
levels
glucose
contents
due
decreased
feed
intake
uptake.
Metabolomic
analysis
revealed
that
exposure
enhanced
glycolysis
but
inhibited
phospholipid
synthesis,
significantly
expression
lipid
metabolism
related
genes
(srebf1,
acox,
pparα),
indicated
β-oxidation.
significant
changes
mitochondrial
membrane
potential,
content,
transcription
involved
respiratory
chain
(mfn2,
ndufs1,
atp5fa1,
mt-nd1)
DNA
replication
(18rs-rrn,
polg1)
suggested
could
cause
dysfunction
further
disrupt
pathways,
ultimately
causing
larvae.
These
findings
demonstrate
importance
assessing
effects
mixtures
on
early
development
wildlife
humans.
Journal of Xenobiotics,
Год журнала:
2025,
Номер
15(1), С. 24 - 24
Опубликована: Фев. 2, 2025
Per-
and
polyfluoroalkyl
substances
(PFAS)
are
synthetic
chemicals
used
in
various
products,
such
as
firefighting
foams
non-stick
cookware,
due
to
their
resistance
heat
degradation.
However,
these
same
properties
make
them
persistent
the
environment
human
body,
raising
public
health
concerns.
This
study
selected
eleven
PFAS
commonly
found
drinking
water
exposed
Caenorhabditis
elegans
concentrations
ranging
from
0.1
200
µM
assess
neurodevelopmental
toxicity
using
a
high-throughput,
high-content
screening
(HTS)
platform
coupled
with
artificial
intelligence
for
image
analysis.
Our
findings
showed
that
6:2
FTS,
HFPO-DA,
PFBA,
PFBS,
PFHxA,
PFOS
inhibited
dopaminergic
neuron
activity,
fluorescence
intensity
reductions
observed
across
100
µM.
PFBS
also
disrupted
synaptic
transmission,
causing
reduced
motility
increased
paralysis
aldicarb-induced
assays,
most
pronounced
effects
at
higher
concentrations.
These
impairments
both
activity
function
led
behavioral
deficits.
Notably,
was
one
of
toxic
PFAS,
affecting
multiple
endpoints.
results
emphasize
developmental
risks
exposure,
highlighting
impact
individual
compounds
mixtures
on
neurodevelopment.
knowledge
is
essential
assessing
PFAS-related
informing
mitigation
strategies.
