Tumor Microenvironment-Activable Manganese-Boosted Catalytic Immunotherapy Combined with PD-1 Checkpoint Blockade DOI
Zhiyu Zhao, Shuming Dong, Yue Liu

et al.

ACS Nano, Journal Year: 2022, Volume and Issue: 16(12), P. 20400 - 20418

Published: Nov. 28, 2022

Immune checkpoint blockade (ICB) therapy has attracted widespread attention in cancer treatment. Due to the low immunogenicity and immune suppression state tumor microenvironment (TME), therapeutic effects are only moderate. Herein, a TME-activable manganese-boosted catalytic immunotherapy is designed for synergism with ICB kill tumors efficiently. The cell membrane (CM)-wrapping multienzyme-mimic manganese oxide (MnOx) nanozyme termed CM@Mn showed intrinsic peroxidase oxidase-like activities an acidic TME. These can generate toxic hydroxyl (•OH) superoxide radicals (•O2-) killing evoking immunogenic death (ICD). Furthermore, TME-responsive release of Mn2+ directly promotes dendritic maturation macrophage M1 repolarization, resulting reversal immunosuppressive TME into immune-activating environment. Additionally, hypoxia relief caused by catalase-like activity also contributes process reversal. Finally, robust tumor-specific T cell-mediated antitumor response occurs support PD-1 blockade. proliferation primary metastatic was inhibited, long-term memory effect induced. strategy outlined here may serve as promising candidate tumor-integrated

Language: Английский

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances DOI

Chenyang Jia,

Yuxin Guo, Fu‐Gen Wu

et al.

Small, Journal Year: 2021, Volume and Issue: 18(6)

Published: Nov. 2, 2021

Abstract Chemodynamic therapy (CDT), a novel cancer therapeutic strategy defined as the treatment using Fenton or Fenton‐like reaction to produce •OH in tumor region, was first proposed by Bu, Shi, and co‐workers 2016. Recently, with rapid development of nanomaterials, CDT has attracted tremendous attention because its unique advantages: 1) It is tumor‐selective low side effects; 2) process does not depend on external field stimulation; 3) it can modulate hypoxic immunosuppressive microenvironment; 4) cost low. In addition Fe‐involved strategies, reaction‐mediated strategies have also been proposed, which are based many other metal elements including copper, manganese, cobalt, titanium, vanadium, palladium, silver, molybdenum, ruthenium, tungsten, cerium, zinc. Moreover, combined therapies like chemotherapy, radiotherapy, phototherapy, sonodynamic therapy, immunotherapy for achieving enhanced anticancer effects. Besides, there studies that extend application antibacterial field. This review introduces latest advancements nanomaterials‐involved from 2018 present proposes current limitations well future research directions related

Language: Английский

Citations

451
Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic‐Synergized Multimodal Therapy DOI

Yaofeng Zhou,

Siyu Fan, Lili Feng

et al.

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(48)

Published: Sept. 27, 2021

Chemodynamic therapy (CDT) uses the tumor microenvironment-assisted intratumoral Fenton reaction for generating highly toxic hydroxyl free radicals (•OH) to achieve selective treatment. However, limited efficiency restricts therapeutic efficacy of CDT. Recent years have witnessed impressive development various strategies increase reaction. The introduction these reinforcement can dramatically improve treatment CDT and further promote enhanced (ECDT)-based multimodal anticancer treatments. In this review, authors systematically introduce strategies, from their basic working principles, mechanisms representative clinical applications. Then, ECDT-based is discussed, including how integrate emerging accelerating therapy, as well synergistic ECDT other methods. Eventually, future direction challenges therapies are elaborated, highlighting key scientific problems unsolved technical bottlenecks facilitate translation.

Language: Английский

Citations

341
Photocatalytic H2O2 production Systems: Design strategies and environmental applications DOI
Zhong Chen,

Ducheng Yao,

Chengcheng Chu

et al.

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 451, P. 138489 - 138489

Published: Aug. 5, 2022

Language: Английский

Citations

335
Copper single-atom catalysts with photothermal performance and enhanced nanozyme activity for bacteria‐infected wound therapy DOI Creative Commons
Xianwen Wang, Qianqian Shi, Zhengbao Zha

et al.

Bioactive Materials, Journal Year: 2021, Volume and Issue: 6(12), P. 4389 - 4401

Published: April 30, 2021

Nanozymes have become a new generation of antibiotics with exciting broad-spectrum antibacterial properties and negligible biological toxicity. However, their inherent low catalytic activity limits properties. Herein, Cu single-atom sites/N doped porous carbon (Cu SASs/NPC) is successfully constructed for photothermal-catalytic treatment by pyrolysis-etching-adsorption-pyrolysis (PEAP) strategy. SASs/NPC stronger peroxidase-like activity, glutathione (GSH)-depleting function, photothermal property compared non-Cu-doped NPC, indicating that doping significantly improves the performance nanozymes. can effectively induce in presence H

Language: Английский

Citations

291
Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging DOI
Jiang Ouyang,

Angel Xie,

Jun Zhou

et al.

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(12), P. 4996 - 5041

Published: Jan. 1, 2022

This review systematically summarizes the research status, challenges, prospects, and potential bench-to-bedside translation of minimally invasive nanomedicines.

Language: Английский

Citations

285
Multivalent metal catalysts in Fenton/Fenton-like oxidation system: A critical review DOI
Yong Liu, Jianlong Wang

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 466, P. 143147 - 143147

Published: April 26, 2023

Language: Английский

Citations

234
Recent advances in enhanced chemodynamic therapy strategies DOI
Qiwei Tian, Fengfeng Xue, Yurui Wang

et al.

Nano Today, Journal Year: 2021, Volume and Issue: 39, P. 101162 - 101162

Published: May 18, 2021

Language: Английский

Citations

233
Guiding Transition Metal‐Doped Hollow Cerium Tandem Nanozymes with Elaborately Regulated Multi‐Enzymatic Activities for Intensive Chemodynamic Therapy DOI
Shuming Dong, Yushan Dong, Bin Liu

et al.

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(7)

Published: Dec. 5, 2021

Clinical applications of nanozyme-initiated chemodynamic therapy (NCDT) have been severely limited by the poor catalytic efficiency nanozymes, insufficient endogenous hydrogen peroxide (H2 O2 ) content, and its off-target consumption. Herein, authors developed a hollow mesoporous Mn/Zr-co-doped CeO2 tandem nanozyme (PHMZCO-AT) with regulated multi-enzymatic activities, that is, enhancement superoxide dismutase (SOD)-like peroxidase (POD)-like activities inhibition catalase (CAT)-like activity. PHMZCO-AT as H2 homeostasis disruptor promotes evolution restrains elimination to achieve intensive NCDT. SOD-like activity catalyzes anion (O2•- into in tumor region. The suppression CAT depletion glutathione largely weaken decomposition O. Elevated is then catalyzed downstream POD-like generate toxic hydroxyl radicals, further inducing apoptosis death. T1 -weighted magnetic resonance imaging X-ray computed tomography are also achieved using due existence paramagnetic Mn2+ high attenuation ability elemental Zr, permitting vivo tracking therapeutic process. This work presents typical paradigm NCDT efficacy regulating nanozymes perturb homeostasis.

Language: Английский

Citations

232
Recent advances of cancer chemodynamic therapy based on Fenton/Fenton-like chemistry DOI Creative Commons

Changyu Cao,

Xiaorui Wang,

Nan Yang

et al.

Chemical Science, Journal Year: 2021, Volume and Issue: 13(4), P. 863 - 889

Published: Nov. 29, 2021

Applying Fenton chemistry in the tumor microenvironment (TME) for cancer therapy is most significant feature of chemodynamic (CDT). Owing to mild acid and overexpressed H2O2 TME, more cytotoxic hydroxyl radicals (˙OH) are generated cells via Fenton-like reactions. Without external stimulus drug resistance generation, reactive oxygen species (ROS)-mediated CDT exhibits a specific desirable anticancer effect has been seen as promising strategy therapy. However, optimizing treatment efficiency TME still challenging because limited catalytic agents strong antioxidant capacity TME. Hence, scientists trying their best design fabricate many with excellent activity remodeling optimal CDT. In this perspective, latest progress discussed, some representative examples presented. Consequently, strategies further guided by provided. Most importantly, several feasible ways developing future offered reference.

Language: Английский

Citations

198
Strategies for enhancing cancer chemodynamic therapy performance DOI
Deblin Jana,

Yanli Zhao

Exploration, Journal Year: 2022, Volume and Issue: 2(2)

Published: March 7, 2022

Chemodynamic therapy (CDT) has emerged to be a frontrunner amongst reactive oxygen species-based cancer treatment modalities. CDT utilizes endogenous H

Language: Английский

Citations

196