Nanomaterials for Flexible Neuromorphics

Chemical Reviews, Год журнала: 2024, Номер 124(22), С. 12738 - 12843

Опубликована: Ноя. 5, 2024

The quest to imbue machines with intelligence akin that of humans, through the development adaptable neuromorphic devices and creation artificial neural systems, has long stood as a pivotal goal in both scientific inquiry industrial advancement. Recent advancements flexible electronics primarily rely on nanomaterials polymers owing their inherent uniformity, superior mechanical electrical capabilities, versatile functionalities. However, this field is still its nascent stage, necessitating continuous efforts materials innovation device/system design. Therefore, it imperative conduct an extensive comprehensive analysis summarize current progress. This review highlights applications neuromorphics, involving inorganic (zero-/one-/two-dimensional, heterostructure), carbon-based such carbon nanotubes (CNTs) graphene, polymers. Additionally, comparison summary structural compositions, design strategies, key performance, significant these are provided. Furthermore, challenges future directions pertaining materials/devices/systems associated neuromorphics also addressed. aim shed light rapidly growing attract experts from diverse disciplines (e.g., electronics, science, neurobiology), foster further for accelerated development.

Язык: Английский

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Conducting Hydrogel‐Based Neural Biointerfacing Technologies

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Abstract Neural biointerfacing, enabling direct communication between neural systems and external devices, holds great promises for applications in brain machine interfaces, prosthetics, neuromodulation. However, current electronics made of conventional rigid materials are challenged by their inherent mechanical mismatch with the tissues. Hydrogel bioelectronics, properties compatible tissues, represent an alternative to these limitations enable next‐generation biointerfacing technology. Here, overview cutting‐edge research on conducting hydrogels (CHs) bioelectronics development, emphasizing material design principles, manufacturing techniques, essential requirements, corresponding application scenarios is presented. Future challenges potential directions regarding CHs‐based technologies, including long‐term reliability, multimodal hydrogel closed‐loop system wireless power supply system, raised. It believed that this review will serve as a valuable resource further advancement implementation

Язык: Английский

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Implantable Soft Neural Electrodes of Liquid Metals for Deep Brain Stimulation

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Фев. 16, 2025

Stimulating large volumes of neural networks using macroelectrodes can modulate disorder-associated brain circuits effectively. However, conventional solid-metal electrodes often cause unwanted damage due to their high mechanical stiffness. In contrast, low-modulus liquid metals provide tissue-like stiffness while maintaining macroscale electrode dimensions. Here, we present implantable soft made from biocompatible for stimulation. These probes be easily fabricated by simply filling polymeric tubes with a metal, offering straightforward method creating stimulation devices. They customized in various lengths and diameters also serve as recording microelectrodes. The tips are enhanced platinum nanoclusters, resulting low impedance effective charge injection preventing metal leakage into tissue. vivo experiments neuropathic pain rat models demonstrate the stability effectiveness these simultaneous recording, demonstrating potential alleviation behavioral control.

Язык: Английский

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An ultrasound-driven implantable wireless energy harvesting system using a triboelectric transducer

Matter, Год журнала: 2022, Номер 5(12), С. 4315 - 4331

Опубликована: Сен. 1, 2022

Язык: Английский

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Scaffold-Based Tissue Engineering Strategies for Osteochondral Repair

Frontiers in Bioengineering and Biotechnology, Год журнала: 2022, Номер 9

Опубликована: Янв. 11, 2022

Over centuries, several advances have been made in osteochondral (OC) tissue engineering to regenerate more biomimetic tissue. As an essential component of engineering, scaffolds provide structural and functional support for cell growth differentiation. Numerous scaffold types, such as porous, hydrogel, fibrous, microsphere, metal, composite decellularized matrix, reported evaluated OC regeneration vitro vivo, with respective advantages disadvantages. Unfortunately, due the inherent complexity organizational structure objective limitations manufacturing technologies biomaterials, we not yet achieved stable satisfactory effects defects repair. In this review, summarize complicated gradients natural then discuss various strategies, focusing on design abundant resources, material fabrication techniques properties.

Язык: Английский

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Identification of an Ultrathin Osteochondral Interface Tissue with Specific Nanostructure at the Human Knee Joint

Nano Letters, Год журнала: 2022, Номер 22(6), С. 2309 - 2319

Опубликована: Март 3, 2022

Cartilage adheres to subchondral bone via a specific osteochondral interface tissue where forces are transferred from soft cartilage hard without conferring fatigue damage over lifetime of load cycles. However, the fine structure and mechanical properties remain unclear. Here, we identified an ultrathin ∼20-30 μm graded calcified region with two-layered micronano structures in human knee joint, which exhibited characteristic biomolecular compositions complex nanocrystals assembly. Results finite element simulations revealed that within this region, exponential increase modulus (3 orders magnitude) was conducive force transmission. Nanoscale heterogeneity hydroxyapatite, coupled enrichment elastic-responsive protein-titin, is usually present muscle, endowed excellent properties. Collectively, these results provide novel insights into potential design for high-performance materials regeneration.

Язык: Английский

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Polymeric multimaterials by photochemical patterning of crystallinity

Science, Год журнала: 2022, Номер 378(6616), С. 211 - 215

Опубликована: Окт. 13, 2022

An organized combination of stiff and elastic domains within a single material can synergistically tailor bulk mechanical properties. However, synthetic methods to achieve such sophisticated architectures remain elusive. We report rapid, facile, environmentally benign method pattern strong semicrystalline phases soft matrices using stereo-controlled ring-opening metathesis polymerization an industrial monomer, cis -cyclooctene. Dual catalysis dictates polyolefin backbone chemistry, which enables patterning compositionally uniform materials with seamless interfaces. Visible light–induced activation catalyst results in the formation trans polyoctenamer rubber, outcompeting occurs at room temperature. This bottom-up approach provides for manufacturing polymeric promising applications optoelectronics robotics.

Язык: Английский

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Periplasmic biomineralization for semi-artificial photosynthesis

Science Advances, Год журнала: 2023, Номер 9(29)

Опубликована: Июль 21, 2023

Semiconductor-based biointerfaces are typically established either on the surface of plasma membrane or within cytoplasm. In Gram-negative bacteria, periplasmic space, characterized by its confinement and presence numerous enzymes peptidoglycans, offers additional opportunities for biomineralization, allowing nongenetic modulation interfaces. We demonstrate semiconductor nanocluster precipitation containing single- multiple-metal elements periplasm, as observed through various electron- x-ray-based imaging techniques. The semiconductors metastable display defect-dominant fluorescent properties. Unexpectedly, defect-rich (i.e., low-grade) nanoclusters produced in situ can still increase adenosine triphosphate levels malate production when coupled with photosensitization. expand sustainability biohybrid system to include reducing heavy metals at primary level, building living bioreactors secondary creating semi-artificial photosynthesis tertiary level. biomineralization-enabled biohybrids have potential serve defect-tolerant platforms diverse sustainable applications.

Язык: Английский

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Tough PEGgels by In Situ Phase Separation for 4D Printing

Advanced Functional Materials, Год журнала: 2023, Номер 34(20)

Опубликована: Апрель 8, 2023

Abstract Polymer gels, consisting of cross‐linked polymer network systems swollen by a solvent, show great potential in biomedicine, flexible electronics, and artificial muscles, due to their tissue‐like mechanical properties. Due the presence large amount improvement properties gel is challenge. Moreover, combining high toughness with useful properties, such as 3D printability or shape‐memory, one system even more challenging. In this study, simple efficient method developed for fabrication tough gels polymerizing 2‐hydroxyethyl methacrylate (HEMA) mixture poly(ethylene glycol) (PEG) poly(propylene (PPG). The polymerized elastic networkpresents distinct compatibility PEG (compatible) PPG (poorly compatible), resulting in‐situ phase separation at microscale. phase‐separated demonstrates strength (8.0 MPa), favorable fracture strain (430%), (17.0 MJ m −3 ). separated hard phasewith glass transition temperature (75 °C) endows whole soft property shape memory room temperature. Finally, tunable PEGgels combined printing well demonstrating use 4D printing.

Язык: Английский

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Tissue-embedded stretchable nanoelectronics reveal endothelial cell–mediated electrical maturation of human 3D cardiac microtissues

Science Advances, Год журнала: 2023, Номер 9(10)

Опубликована: Март 8, 2023

Clinical translation of stem cell therapies for heart disease requires electrical integration transplanted cardiomyocytes. Generation electrically matured human induced pluripotent cell-derived cardiomyocytes (hiPSC-CMs) is critical integration. Here, we found that hiPSC-derived endothelial cells (hiPSC-ECs) promoted the expression selected maturation markers in hiPSC-CMs. Using tissue-embedded stretchable mesh nanoelectronics, achieved a long-term stable map three-dimensional (3D) cardiac microtissue activity. The results revealed hiPSC-ECs accelerated hiPSC-CMs 3D microtissues. Machine learning-based pseudotime trajectory inference cardiomyocyte signals further phenotypic transition path during development. Guided by recording data, single-cell RNA sequencing identified subpopulations with more mature phenotype, and multiple ligand-receptor interactions were up-regulated between hiPSC-CMs, revealing coordinated multifactorial mechanism hiPSC-CM maturation. Collectively, these findings show drive via intercellular pathways.

Язык: Английский

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