ACS Applied Materials & Interfaces,
Journal Year:
2022,
Volume and Issue:
14(29), P. 33641 - 33649
Published: July 14, 2022
A
flexible
pressure
sensor
array
provides
more
information
than
a
single
as
electronic
skin,
and
independently
definable
sensitivities
of
sensing
pixels
enable
accurate
measurements.
However,
the
reported
approaches,
either
changing
mold
for
dielectric
layer
or
tuning
properties,
overcomplicate
manufacturing
process
devices.
Here,
we
present
with
photo-patterned
sensitivity,
which
is
realized
through
synergistic
creation
photo-defined
mechanical
properties
interfacial
capacitive
mechanism.
Via
this
design,
sensitivity
each
pixel
can
be
over
range
∼70
times
magnitude.
Additionally,
created
first
wearable
measurement
unit
ionic
array.
The
sensitivity-photo-patternable
fulfill
open
need
mapping
distribution
broad
magnitude,
such
plantar
pressure.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 28, 2025
Abstract
Neural
biointerfacing,
enabling
direct
communication
between
neural
systems
and
external
devices,
holds
great
promises
for
applications
in
brain
machine
interfaces,
prosthetics,
neuromodulation.
However,
current
electronics
made
of
conventional
rigid
materials
are
challenged
by
their
inherent
mechanical
mismatch
with
the
tissues.
Hydrogel
bioelectronics,
properties
compatible
tissues,
represent
an
alternative
to
these
limitations
enable
next‐generation
biointerfacing
technology.
Here,
overview
cutting‐edge
research
on
conducting
hydrogels
(CHs)
bioelectronics
development,
emphasizing
material
design
principles,
manufacturing
techniques,
essential
requirements,
corresponding
application
scenarios
is
presented.
Future
challenges
potential
directions
regarding
CHs‐based
technologies,
including
long‐term
reliability,
multimodal
hydrogel
closed‐loop
system
wireless
power
supply
system,
raised.
It
believed
that
this
review
will
serve
as
a
valuable
resource
further
advancement
implementation
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 16, 2025
Stimulating
large
volumes
of
neural
networks
using
macroelectrodes
can
modulate
disorder-associated
brain
circuits
effectively.
However,
conventional
solid-metal
electrodes
often
cause
unwanted
damage
due
to
their
high
mechanical
stiffness.
In
contrast,
low-modulus
liquid
metals
provide
tissue-like
stiffness
while
maintaining
macroscale
electrode
dimensions.
Here,
we
present
implantable
soft
made
from
biocompatible
for
stimulation.
These
probes
be
easily
fabricated
by
simply
filling
polymeric
tubes
with
a
metal,
offering
straightforward
method
creating
stimulation
devices.
They
customized
in
various
lengths
and
diameters
also
serve
as
recording
microelectrodes.
The
tips
are
enhanced
platinum
nanoclusters,
resulting
low
impedance
effective
charge
injection
preventing
metal
leakage
into
tissue.
vivo
experiments
neuropathic
pain
rat
models
demonstrate
the
stability
effectiveness
these
simultaneous
recording,
demonstrating
potential
alleviation
behavioral
control.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2022,
Volume and Issue:
9
Published: Jan. 11, 2022
Over
centuries,
several
advances
have
been
made
in
osteochondral
(OC)
tissue
engineering
to
regenerate
more
biomimetic
tissue.
As
an
essential
component
of
engineering,
scaffolds
provide
structural
and
functional
support
for
cell
growth
differentiation.
Numerous
scaffold
types,
such
as
porous,
hydrogel,
fibrous,
microsphere,
metal,
composite
decellularized
matrix,
reported
evaluated
OC
regeneration
vitro
vivo,
with
respective
advantages
disadvantages.
Unfortunately,
due
the
inherent
complexity
organizational
structure
objective
limitations
manufacturing
technologies
biomaterials,
we
not
yet
achieved
stable
satisfactory
effects
defects
repair.
In
this
review,
summarize
complicated
gradients
natural
then
discuss
various
strategies,
focusing
on
design
abundant
resources,
material
fabrication
techniques
properties.
Nano Letters,
Journal Year:
2022,
Volume and Issue:
22(6), P. 2309 - 2319
Published: March 3, 2022
Cartilage
adheres
to
subchondral
bone
via
a
specific
osteochondral
interface
tissue
where
forces
are
transferred
from
soft
cartilage
hard
without
conferring
fatigue
damage
over
lifetime
of
load
cycles.
However,
the
fine
structure
and
mechanical
properties
remain
unclear.
Here,
we
identified
an
ultrathin
∼20-30
μm
graded
calcified
region
with
two-layered
micronano
structures
in
human
knee
joint,
which
exhibited
characteristic
biomolecular
compositions
complex
nanocrystals
assembly.
Results
finite
element
simulations
revealed
that
within
this
region,
exponential
increase
modulus
(3
orders
magnitude)
was
conducive
force
transmission.
Nanoscale
heterogeneity
hydroxyapatite,
coupled
enrichment
elastic-responsive
protein-titin,
is
usually
present
muscle,
endowed
excellent
properties.
Collectively,
these
results
provide
novel
insights
into
potential
design
for
high-performance
materials
regeneration.
Science,
Journal Year:
2022,
Volume and Issue:
378(6616), P. 211 - 215
Published: Oct. 13, 2022
An
organized
combination
of
stiff
and
elastic
domains
within
a
single
material
can
synergistically
tailor
bulk
mechanical
properties.
However,
synthetic
methods
to
achieve
such
sophisticated
architectures
remain
elusive.
We
report
rapid,
facile,
environmentally
benign
method
pattern
strong
semicrystalline
phases
soft
matrices
using
stereo-controlled
ring-opening
metathesis
polymerization
an
industrial
monomer,
cis
-cyclooctene.
Dual
catalysis
dictates
polyolefin
backbone
chemistry,
which
enables
patterning
compositionally
uniform
materials
with
seamless
interfaces.
Visible
light–induced
activation
catalyst
results
in
the
formation
trans
polyoctenamer
rubber,
outcompeting
occurs
at
room
temperature.
This
bottom-up
approach
provides
for
manufacturing
polymeric
promising
applications
optoelectronics
robotics.
Science Advances,
Journal Year:
2023,
Volume and Issue:
9(29)
Published: July 21, 2023
Semiconductor-based
biointerfaces
are
typically
established
either
on
the
surface
of
plasma
membrane
or
within
cytoplasm.
In
Gram-negative
bacteria,
periplasmic
space,
characterized
by
its
confinement
and
presence
numerous
enzymes
peptidoglycans,
offers
additional
opportunities
for
biomineralization,
allowing
nongenetic
modulation
interfaces.
We
demonstrate
semiconductor
nanocluster
precipitation
containing
single-
multiple-metal
elements
periplasm,
as
observed
through
various
electron-
x-ray-based
imaging
techniques.
The
semiconductors
metastable
display
defect-dominant
fluorescent
properties.
Unexpectedly,
defect-rich
(i.e.,
low-grade)
nanoclusters
produced
in
situ
can
still
increase
adenosine
triphosphate
levels
malate
production
when
coupled
with
photosensitization.
expand
sustainability
biohybrid
system
to
include
reducing
heavy
metals
at
primary
level,
building
living
bioreactors
secondary
creating
semi-artificial
photosynthesis
tertiary
level.
biomineralization-enabled
biohybrids
have
potential
serve
defect-tolerant
platforms
diverse
sustainable
applications.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
34(20)
Published: April 8, 2023
Abstract
Polymer
gels,
consisting
of
cross‐linked
polymer
network
systems
swollen
by
a
solvent,
show
great
potential
in
biomedicine,
flexible
electronics,
and
artificial
muscles,
due
to
their
tissue‐like
mechanical
properties.
Due
the
presence
large
amount
improvement
properties
gel
is
challenge.
Moreover,
combining
high
toughness
with
useful
properties,
such
as
3D
printability
or
shape‐memory,
one
system
even
more
challenging.
In
this
study,
simple
efficient
method
developed
for
fabrication
tough
gels
polymerizing
2‐hydroxyethyl
methacrylate
(HEMA)
mixture
poly(ethylene
glycol)
(PEG)
poly(propylene
(PPG).
The
polymerized
elastic
networkpresents
distinct
compatibility
PEG
(compatible)
PPG
(poorly
compatible),
resulting
in‐situ
phase
separation
at
microscale.
phase‐separated
demonstrates
strength
(8.0
MPa),
favorable
fracture
strain
(430%),
(17.0
MJ
m
−3
).
separated
hard
phasewith
glass
transition
temperature
(75
°C)
endows
whole
soft
property
shape
memory
room
temperature.
Finally,
tunable
PEGgels
combined
printing
well
demonstrating
use
4D
printing.
Science Advances,
Journal Year:
2023,
Volume and Issue:
9(10)
Published: March 8, 2023
Clinical
translation
of
stem
cell
therapies
for
heart
disease
requires
electrical
integration
transplanted
cardiomyocytes.
Generation
electrically
matured
human
induced
pluripotent
cell-derived
cardiomyocytes
(hiPSC-CMs)
is
critical
integration.
Here,
we
found
that
hiPSC-derived
endothelial
cells
(hiPSC-ECs)
promoted
the
expression
selected
maturation
markers
in
hiPSC-CMs.
Using
tissue-embedded
stretchable
mesh
nanoelectronics,
achieved
a
long-term
stable
map
three-dimensional
(3D)
cardiac
microtissue
activity.
The
results
revealed
hiPSC-ECs
accelerated
hiPSC-CMs
3D
microtissues.
Machine
learning-based
pseudotime
trajectory
inference
cardiomyocyte
signals
further
phenotypic
transition
path
during
development.
Guided
by
recording
data,
single-cell
RNA
sequencing
identified
subpopulations
with
more
mature
phenotype,
and
multiple
ligand-receptor
interactions
were
up-regulated
between
hiPSC-CMs,
revealing
coordinated
multifactorial
mechanism
hiPSC-CM
maturation.
Collectively,
these
findings
show
drive
via
intercellular
pathways.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(31)
Published: May 28, 2024
Understanding
psychology
is
an
important
task
in
modern
society
which
helps
predict
human
behavior
and
provide
feedback
accordingly.
Monitoring
of
weak
psychological
emotional
changes
requires
bioelectronic
devices
to
be
stretchable
compliant
for
unobtrusive
high-fidelity
signal
acquisition.
Thin
conductive
polymer
film
regarded
as
ideal
interface;
however,
it
very
challenging
simultaneously
balance
mechanical
robustness
opto-electrical
property.
Here,
a
40
nm-thick
based
on
photolithographic
double-network
mediated
by
graphene
layer
reported,
concurrently
enables
stretchability,
conductivity,
conformability.
Photolithographic
endow
the
photopatternability,
enhance
stress
dissipation
capability,
well
improve
conductivity
(4458
S
cm
