Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114030 - 114030
Published: Feb. 1, 2025
Language: Английский
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Nov. 15, 2024
Abstract Nanotechnology holds immense promise in revolutionising healthcare, offering unprecedented opportunities diagnostics, drug delivery, cancer therapy, and combating infectious diseases. This review explores the multifaceted landscape of nanotechnology healthcare while addressing critical aspects safety environmental risks associated with its widespread application. Beginning an introduction to integration we first delved into categorisation various materials employed, setting stage for a comprehensive understanding potential. We then proceeded elucidate diverse applications nanotechnology, spanning medical tissue engineering, targeted gene development antimicrobial agents. The discussion extended current situation surrounding clinical translation commercialisation these cutting-edge technologies, focusing on nanotechnology-based products that have been approved globally date. also discussed considerations nanomaterials, both terms human health impact. presented vivo nanomaterial exposure, relation transport mechanisms, oxidative stress, physical interactions. Moreover, highlighted risks, acknowledging potential implications ecosystems biodiversity. Lastly, strived offer insights regulatory governing across different regions globally. By synthesising perspectives, underscore imperative balancing innovation stewardship, charting path forward responsible healthcare. Graphical abstract
Language: Английский
Citations
40
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 7547 - 7566
Published: July 1, 2024
Abstract: Cancer poses a significant threat to human life and health. Chemotherapy is currently one of the effective cancer treatments, but many chemotherapy drugs have cell toxicity, low solubility, poor stability, narrow therapeutic window, unfavorable pharmacokinetic properties. To solve above problems, target drug delivery tumor cells, reduce side effects drugs, an anti-tumor system based on microenvironment has become focus research in recent years. The construction reduction-sensitive nanomedicine disulfide bonds attracted much attention. Disulfide good reductive responsiveness can effectively high glutathione (GSH) levels environment, enabling precise delivery. further enhance targeting accelerate release, are often combined with pH-responsive nanocarriers highly expressed ligands cells construct systems. connect molecules polymer system, as well between different carrier molecules. This article summarized systems (DDS) that researchers constructed years bond microenvironment, cleavage-triggering conditions, various loading strategies, design. In this review, we also discuss controlled release mechanisms these DDS clinical applicability challenges faced translation. Keywords: bond, systems, GSH/ROS
Language: Английский
Citations
22
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 22, 2024
Abstract In designing aerosolized drugs, the challenge lies in achieving optimal penetration and retention. Existing delivery systems prioritize larger particles for prolonged intrapulmonary retention, compromising speed. Conversely, smaller nanoparticles face rapid clearance limited RNA sponges featuring multiple microRNA binding sites exhibit promising potential gene expression regulation. However, complex structure of frequently utilized cyclic sponge impedes cellular uptake, restricting its application. This study proposes an innovative approach using a compact tetrahedral framework nucleic acid to construct inhalable sponge. Distinguished by simplified structure, this ensures effective inhibition, tissue penetration, residency through prompt endocytosis. Validated acute lung inflammation models, demonstrates swift restoration local immune homeostasis. design addresses critical need aerosol vehicles that balance efficient sustained offering solution
Language: Английский
Citations
22
Frontiers in Nanotechnology, Journal Year: 2024, Volume and Issue: 6
Published: Oct. 11, 2024
Nanoparticulate delivery systems have been attracting attention in pharmaceutical sciences for enhanced drug bioavailability and targeted delivery. Specifically, these can enhance the solubility of poorly water-soluble drugs, protect therapeutic agents from degradation, prolong circulation time body, control release, facilitate precise targeting drugs to specific tissues or cells. However, once administered into nanoparticles often encounter significant challenges that affect their efficacy safety, such as issues with stability, biocompatibility, targeting. The surface properties are one most important features they greatly influence interactions between themselves biological targets. Key characteristics, charge, hydrophobicity, presence functional groups, determine how behave environments, thereby influencing cellular uptake, ability avoid immune clearance. Modification nanoparticle has shown be an effective approach modulate physicochemical nanoparticles, achieving desired vivo . This review aims summarize recent advances decoration emphasis on improved colloidal reduced toxicity, future perspectives modification approaches also discussed.
Language: Английский
Citations
20
Cancers, Journal Year: 2025, Volume and Issue: 17(4), P. 701 - 701
Published: Feb. 19, 2025
Glioblastoma multiforme (GBM) is a highly malignant brain tumor that has bleak outlook despite existing treatments such as surgery, radiation, and chemotherapy. The utilization of nanoparticles for drug delivery presents promising method by which to improve the effectiveness treatment while reducing harmful effects on entire body. This review examines application in GBM, focusing different types nanoparticles, including lipid-based, polymeric, metallic, those under development. Every variety analyzed its distinct characteristics therapeutic capacity. Lipid-based liposomes solid lipid enhance transport medicines are not soluble water have shown considerable potential preclinical investigations. Polymeric benefits terms controlled release targeted distribution, whereas metallic both therapy imaging. In current we would like emphasize ways medicine delivery, specifically enhancing penetration blood-brain barrier (BBB), targeting tumors, enabling release. Additionally, also discuss clinical discoveries, highlighting achievements obstacles process converting these technologies into effective GBM. study offers thorough examination present status prospects
Language: Английский
Citations
5
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Nucleic acid therapeutics represent a highly promising treatment approach in modern medicine, treating diseases at the genetic level. However, these face numerous challenges practical applications, particularly regarding their stability, effectiveness, cellular uptake efficiency, and limitations delivering them specifically to target tissues. To overcome obstacles, researchers have developed various innovative delivery systems, including viral vectors, lipid nanoparticles, polymer inorganic protein carriers, exosomes, antibody oligonucleotide conjugates, DNA nanostructure-based systems. These systems enhance therapeutic efficacy of nucleic drugs by improving targeting specificity, half-life vivo. In this review, we systematically discuss different types drugs, analyze major barriers encountered delivery, summarize current research progress emerging We also highlight latest advancements application for diseases, infectious cancer, brain wound healing. This review aims provide comprehensive overview drug systems' status future directions integrating nanotechnology, biomaterials science, gene editing technologies, emphasizing transformative potential precision medicine.
Language: Английский
Citations
4
Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 126999 - 126999
Published: Jan. 1, 2025
Language: Английский
Citations
4
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 375 - 375
Published: March 15, 2025
Recent progress in material science has led to the development of new drug delivery systems that go beyond conventional approaches and offer greater accuracy convenience application therapeutic agents. This review discusses evolutionary role nanocarriers, hydrogels, bioresponsive polymers enhanced release, target accuracy, bioavailability. Oncology, chronic disease management, vaccine are some applications explored this paper show how these materials improve results, counteract multidrug resistance, allow for sustained localized treatments. The also translational barriers bringing advanced into clinical setting, which include issues biocompatibility, scalability, regulatory approval. Methods overcome challenges surface modifications reduce immunogenicity, scalable production methods such as microfluidics, harmonization systems. In addition, convergence artificial intelligence (AI) machine learning (ML) is opening frontiers personalized medicine. These technologies predictive modeling real-time adjustments optimize needs individual patients. use can be applied rare underserved diseases; thus, strategies gene therapy, orphan drugs development, global distribution may hopes millions
Language: Английский
Citations
4
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141394 - 141394
Published: Feb. 1, 2025
Language: Английский
Citations
3
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 517, P. 216054 - 216054
Published: July 2, 2024
Language: Английский
Citations
18