Toxic effects of nanoplastics and microcystin-LR coexposure on the liver-gut axis of Hypophthalmichthys molitrix

The Science of The Total Environment, Год журнала: 2024, Номер 916, С. 170011 - 170011

Опубликована: Янв. 13, 2024

Язык: Английский

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The azole biocide climbazole induces oxidative stress, inflammation, and apoptosis in fish gut

The Science of The Total Environment, Год журнала: 2024, Номер 923, С. 171475 - 171475

Опубликована: Март 6, 2024

Язык: Английский

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Benzimidazole Fungicide Carbendazim Induces Gut Inflammation through the TLR5/NF-κB Pathway in Grass Carp

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 2, 2025

Fungicides have been increasingly used across various sectors, including agriculture and textiles. The biocidal properties of fungicides may negatively impact the stability intestinal microbiota, thereby posing a threat to health. In this study, we investigated mechanisms damage functional abnormalities in grass carp following 42-day exposure widely fungicide carbendazim at environmentally relevant concentrations (0.2 20 μg/L). Histopathological observations, mRNA protein expression analyses, biochemical analysis, quantification short-chain fatty acids (SCFAs), cytokines, lipopolysaccharide (LPS), 16S ribosomal ribonucleic acid (rRNA), as well internal transcribed spacer (ITS) sequencing, were performed. At concentrations, strongly induced inflammation, leading increased transcriptional translational levels genes involved toll-like receptor five (TLR5)/nuclear factor kappa B (NF-κB) pathway, TLR5, NF-κB, interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNFα). Additionally, damaged barriers reduced tight junction proteins (e.g., occludin zonula occludens-1/2), goblet cells, immunoglobulin M levels, while also disrupting gut microbiome, metabolic disorders, particularly decreases SCFAs increases LPS. Treatment with TLR5 antagonist TH1020 mitigated inflammation caused by carbendazim, subsequently improving mechanical barrier function. Overall, our findings provide new insights into toxicological underlying carp, indicating that poses significant nontarget organisms. Given its widespread detection environment, these results underscore substantial ecological risks health fish living carbendazim-contaminated water bodies.

Язык: Английский

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An azole fungicide climbazole damages the gut-brain axis in the grass carp

Journal of Hazardous Materials, Год журнала: 2024, Номер 465, С. 133463 - 133463

Опубликована: Янв. 10, 2024

Язык: Английский

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Integrated physiological, intestinal microbiota, and metabolomic responses of adult zebrafish (Danio rerio) to subacute exposure to antimony at environmentally relevant concentrations

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 277, С. 116326 - 116326

Опубликована: Апрель 18, 2024

The available information regarding the impact of antimony (Sb), a novel environmental pollutant, on intestinal microbiota and host health is limited. In this study, we conducted physiological characterizations to investigate response adult zebrafish different concentrations (0, 30, 300, 3000 µg/L) Sb over period 14 days. Biochemical pathological changes demonstrated that effectively compromised integrity physical barrier induced inflammatory responses as well oxidative stress. Analysis both microbial community metabolome revealed exposure 0 30 µg/L resulted in similar structures; however, 300 altered communities' composition (e.g., decline genus Cetobacterium an increase Vibrio). Furthermore, significantly decreased levels bile acids glycerophospholipids while triggering inflammation but activating self-protective mechanisms such antibiotic presence. Notably, even can trigger dysbiosis metabolites, potentially impacting fish through "microbiota-intestine-brain axis" contributing disease initiation. This study provides valuable insights into toxicity-related concerning impacts aquatic organisms with significant implications for developing management strategies.

Язык: Английский

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Gut microbiota disorders aggravate terbuthylazine-induced mitochondrial quality control disturbance and PANoptosis in chicken hepatocyte through gut-liver axis

The Science of The Total Environment, Год журнала: 2023, Номер 913, С. 169642 - 169642

Опубликована: Дек. 29, 2023

Язык: Английский

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Exploring the impact of antibiotics, microplastics, nanoparticles, and pesticides on zebrafish gut microbiomes: Insights into composition, interactions, and health implications

Chemosphere, Год журнала: 2023, Номер 349, С. 140867 - 140867

Опубликована: Дек. 2, 2023

Язык: Английский

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How do microplastics alter molluscicidal activity? Effects of weathered microplastics and niclosamide in developing freshwater snails

The Science of The Total Environment, Год журнала: 2024, Номер 922, С. 171165 - 171165

Опубликована: Фев. 22, 2024

Язык: Английский

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Bis(2-ethylhexyl)-tetrabromophthalate Poses a Higher Exposure Risk and Induces Gender-Specific Metabolic Disruptions in Zebrafish Liver

Environmental Science & Technology, Год журнала: 2024, Номер 58(11), С. 4937 - 4947

Опубликована: Март 6, 2024

Bis(2-ethylhexyl)-tetrabromophthalate (TBPH), a typical novel brominated flame retardant, has been ubiquitously identified in various environmental and biotic media. Consequently, there is an urgent need for precise risk assessment based on comprehensive understanding of internal exposure the corresponding toxic effects specific tissues. In this study, we first investigated toxicokinetic characteristics TBPH different tissues using classical pseudo-first-order model. We found that was prone to accumulate liver rather than gonad, brain, muscle both female male zebrafish, highlighting higher liver. Furthermore, long-term at environmentally relevant concentrations led increased visceral fat accumulation, signaling potential abnormal function. Hepatic transcriptome analysis predominantly implicated glycolipid metabolism pathways. However, alterations profile associated genes biochemical indicators revealed gender-specific responses following exposure. Besides, histopathological observations as well inflammatory response confirmed development nonalcoholic fatty disease, particularly zebrafish. Altogether, our findings highlight liver, enhancing metabolic-disrupting with

Язык: Английский

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Niclosamide exposure disrupts antioxidant defense, histology, and the liver and gut transcriptome of Chinese soft-shelled turtle (Pelodiscus sinensis)

Ecotoxicology and Environmental Safety, Год журнала: 2023, Номер 260, С. 115081 - 115081

Опубликована: Май 30, 2023

Niclosamide (NIC) is the only commercially available molluscicide for controlling schistosomiasis, and its negative effects on aquatic animals had been frequently reported in recent years. However, toxicity mechanism of NIC Chinese soft-shelled turtle (Pelodiscus sinensis) have not yet investigated. Therefore, juvenile turtles were exposed to 0 (control group), 10 (low NIC, L), 50 (high H) μg/L 120 h our results demonstrated that exposure induced severe pathological changes liver P. sinensis. And typical symptom included edema, nuclear migration deformation, vacuolization. Compared with liver, did cause significant damage gut tissue. In addition, DHE staining ROS production increased increase concentration NIC. The activities antioxidant enzymes including superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) was inhibited malondialdehyde (MDA) content, indicating defense significantly perturbed. Further, transcriptome sequencing applied evaluate underlying mechanisms Pathway enrichment showed disorder lipid metabolism innate immune regulation, Toll-like receptors (TLRs), tumor necrosis factor (TNF), lectins, complement coagulation cascades, toxicological properties Overall, current study provides valuable information understand toxic effect turtle.

Язык: Английский

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