medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 2, 2024
Abstract
Objectives
This
review
aims
to
provide
a
comprehensive
examination
of
biomarkers
and
interdisciplinary
variables
related
aging.
Methods
scoping
included
studies
which
involved
adult
participants,
reported
on
the
relationship
between
any
biomarker
or
biological
age
with
chronological
age.
Results
After
screening,
447
articles
met
selection
criteria.
were
categorized
into
10
distinct
categories
through
an
iterative
process.
Conclusions
contributes
information
regarding
influences
rate
Telomere
length
was
most
commonly
examined
biomarker,
Horvath’s
353-CpG
Pan-Tissue
clock
common
clock,
both
demonstrating
strong
consistent
The
demonstrated
relationships
aging
varying
strengths
consistencies.
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
277, С. 116398 - 116398
Опубликована: Апрель 26, 2024
PM2.5
and
its
chemical
components
increase
health
risks
are
associated
with
depression
gut
microbiota.
However,
there
is
still
limited
evidence
on
whether
microbiota
short-chain
fatty
acids
(SCFAs)
mediate
the
association
between
PM2.5,
components,
antenatal
depression.
The
purpose
of
this
study
was
to
investigate
mediating
role
maternal
in
correlations
short-term
exposure
Demographic
information
stool
samples
were
collected
from
75
pregnant
women
their
third
trimester.
Their
measured.
Participants
divided
into
non-antenatal
group
or
according
cut-off
10
points
Edinburgh
Postnatal
Depression
Scale
(EPDS).
analyzed
using
16
S
rRNA-V3/V4
gene
sequence,
concentration
calculated
Tracking
Air
Pollution
China
(TAP)
database.
Gas
chromatography–mass
spectrometry
used
analyze
SCFAs
samples.
In
order
assess
effects
SCFAs,
mediation
models
utilized.
There
significant
differences
microbial
composition
concentrations
group.
positively
EPDS
scores
negatively
genera
Enterococcus
Enterobacter.
Genera
Candidatus_Soleaferrea
(β
=
−7.21,
95%CI
−11.00
−3.43,
q
0.01)
−2.37,
−3.87
−0.87,
0.02)
scores,
indicating
potential
protective
against
no
scores.
different
lagged
periods
component
exposure,
revealed.
For
instance,
explained
29.23%
(95%CI
2.16–87.13%,
p
0.04)
associations
level
at
day
sampling
(lag
0)
Our
highlights
that
may
mechanism
through
which
influences
PM2.5-induced
needs
be
further
studied.
EClinicalMedicine,
Год журнала:
2025,
Номер
82, С. 103178 - 103178
Опубликована: Апрель 1, 2025
Biological
age
(BA)
is
considered
a
better
predictor
of
aging
than
chronological
(CA).
BA
acceleration
was
defined
as
the
disparity
between
and
CA.
However,
there
has
been
inconclusive
evidence
on
whether
might
be
reversed
by
increased
total
testosterone
(TT).
The
goal
this
cross-sectional
study
to
investigate
relationship
TT
acceleration.
Klemera
Doubal
method
biological
(KDM-BA)
employed
an
indicator
in
study.
This
involved
participants
three
ancestries
from
five
cohorts,
including
National
Health
Nutrition
Examination
Survey
(NHANES,
recruited
1
January
2011
31
December
2016),
West
China
Aging
Trend
(WCHAT,
2018
2018),
Natural
Population
Cohort
Study
(WCNPCS,
2019
2020),
UK
Biobank
(UKB,
3
March
2016
October
Hospital
robot-assisted
radical
prostatectomy
(RARP)
cohort
(recruited
2017
2023).
Association
serum
were
assessed
multivariable
linear
regression
NHANES,
WCHAT,
WCNPCS.
Change-to-change
analysis
performed
evaluate
association
dynamic
UKB.
38
prostate
cancer
patients
underwent
adjuvant
androgen
deprivation
therapy
(ADT)
included
exploring
ADT
deteriorates
A
6976,
2080,
2133,
6058
WCNPCS,
UKB,
respectively,
Higher
consistently
associated
with
attenuated
across
In
Box-Cox
negatives
allowed
(BCN)-transformed
relative
change
significantly
decreased
BCN-transformed
(β:
-0.047,
95%
CI:
-0.057
-0.038).
results
remained
robust
stratification
analysis,
restricted
cubic
spline
(RCS),
sensitivity
analysis.
pre-and-post
paired
test
further
indicated
accelerated
patients.
reveals
that
higher
reduced
aging.
Men
repeat
testing
demonstrated
Comparison
men
revealed
advanced
after
receiving
ADT.
suggests
may
reasonable
for
key
research
development
program
China,
Programs
Science
Technology
Department
Sichuan
Province,
Clinical
Research
Center
Geriatrics,
Hospital,
University.
Biomedicines,
Год журнала:
2024,
Номер
12(8), С. 1716 - 1716
Опубликована: Авг. 1, 2024
The
term
'inflammaging'
has
been
coined
to
describe
the
chronic
state
of
inflammation
derived
from
ongoing
cycles
tissue
damage
and
subsequent
immune
responses.
This
inflammatory
status
contributes
decline
organs
physiological
functions,
accelerates
aging
process,
increases
risk
age-related
illnesses
death.
During
aging,
gut
microbiota
(GM)
undergoes
significant
changes,
including
a
decreased
diversity
species,
in
beneficial
bacteria,
rise
proinflammatory
ones,
resulting
persistent
low-grade
inflammation.
Moreover,
environmental
factors,
such
as
diet
medications,
contribute
changes
GM
function,
preventing
or
promoting
inflammaging.
narrative
review
aims
clarify
underlying
mechanisms
inflammaging
specifically
investigate
influence
several
factors
on
these
mechanisms,
while
also
exploring
potential
differences
related
sex.
lifestyle
pharmacological
interventions
will
be
suggested
promote
healthy
aging.
Environmental Science & Technology,
Год журнала:
2024,
Номер
58(41), С. 18064 - 18075
Опубликована: Окт. 4, 2024
Long-term
exposure
to
traffic-related
air
pollution
(TRAP)
is
associated
with
cardiometabolic
disease;
however,
its
role
in
subclinical
stages
of
disease
development
unclear.
Thus,
we
aimed
explore
this
association
a
cross-sectional
analysis,
phenotypes
derived
from
magnetic
resonance
imaging
(MRI).
Phenotypes
the
left
(LV)
and
right
cardiac
ventricle,
whole-body
adipose
tissue
(AT),
organ-specific
AT
were
obtained
by
MRI
400
participants
KORA
cohort.
Land-use
regression
models
used
estimate
residential
long-term
exposures
TRAP,
e.g.,
nitrogen
dioxides
(NO
