Research Progress on Micro(nano)plastic-Induced Programmed Cell Death Associated with Disease Risks DOI Creative Commons

Huanpeng Liu,

Huiqi Li, Ting Chen

и другие.

Toxics, Год журнала: 2024, Номер 12(7), С. 493 - 493

Опубликована: Июль 5, 2024

Due to their robust migration capabilities, slow degradation, and propensity for adsorbing environmental pollutants, micro(nano)plastics (MNPs) are pervasive across diverse ecosystems. They infiltrate various organisms within different food chains through multiple pathways including inhalation dermal contact, pose a significant challenge in the 21st century. Research indicates that MNPs health threats broad range of organisms, humans. Currently, extensive detection data studies using experimental animals vitro cell culture indicate can trigger forms programmed death (PCD) induce diseases. This review provides comprehensive systematic analysis MNP-induced PCD processes, pyroptosis, ferroptosis, autophagy, necroptosis, apoptosis, based on recent research findings focuses elucidating links between Additionally, targeted therapeutic interventions these diseases described. original insights into opportunities challenges posed by current findings. evaluates ways mitigate resulting from patterns. Moreover, this paper enhances understanding biohazards associated with providing reference subsequent toxicological risk mitigation efforts.

Язык: Английский

Micro(nano)plastics in the Human Body: Sources, Occurrences, Fates, and Health Risks DOI
Penghui Li,

Jingfu Liu

Environmental Science & Technology, Год журнала: 2024, Номер unknown

Опубликована: Фев. 5, 2024

The increasing global attention on micro(nano)plastics (MNPs) is a result of their ubiquity in the water, air, soil, and biosphere, exposing humans to MNPs daily basis threatening human health. However, crucial data body, including sources, occurrences, behaviors, health risks, are limited, which greatly impedes any systematic assessment impact body. To further understand effects we must identify existing knowledge gaps that need be immediately addressed provide potential solutions these issues. Herein, examined current literature behaviors body as well risks. Furthermore, identified key resolved comprehensively assess Additionally, complexity lack efficient analytical methods main barriers impeding investigations necessitating development standard unified method. Finally, highlighted for interdisciplinary studies from environmental, biological, medical, chemical, computer, material scientists fill drive research. Considering inevitability occurrence exposure MNPs, more urgently required enhance our understanding negative

Язык: Английский

Процитировано

48
Microplastics in the human body: A comprehensive review of exposure, distribution, migration mechanisms, and toxicity DOI

Yue Li,

Liping Chen,

Nonglin Zhou

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 946, С. 174215 - 174215

Опубликована: Июнь 22, 2024

Язык: Английский

Процитировано

46
A comprehensive review on the source, ingestion route, attachment and toxicity of microplastics/nanoplastics in human systems DOI
Yining Zhu,

Ruijie Che,

Xinyan Zong

и другие.

Journal of Environmental Management, Год журнала: 2024, Номер 352, С. 120039 - 120039

Опубликована: Янв. 13, 2024

Язык: Английский

Процитировано

37
Revealing new insights: Two-center evidence of microplastics in human vitreous humor and their implications for ocular health DOI

Yizhou Zhong,

Yuhang Yang, Linan Zhang

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 921, С. 171109 - 171109

Опубликована: Фев. 21, 2024

Язык: Английский

Процитировано

33
Microplastic and plastic pollution: impact on respiratory disease and health DOI Creative Commons
Gwenda F. Vasse, Barbro N. Melgert

European Respiratory Review, Год журнала: 2024, Номер 33(172), С. 230226 - 230226

Опубликована: Апрель 30, 2024

Throughout their lifecycle, from production to use and upon disposal, plastics release chemicals particles known as micro- nanoplastics (MNPs) that can accumulate in the environment. MNPs have been detected different locations of human body, including our lungs. This is likely a consequence MNP exposure through air we breathe. Yet, still lack comprehensive understanding impact may on respiratory disease health. In this review, collated current body evidence implications inhalation lung health vitro , vivo occupational studies. We focused interactions between pollution specific lung-resident cells diseases. conclude it evident possess capacity affect tissue remains unclear which extent occurs ambient levels MNPs, emphasising need for more evaluation environmental everyday life.

Язык: Английский

Процитировано

30
Systematic review of pulmonary toxicity induced by microplastics and nanoplastics: Insights from in vivo and in vitro studies DOI

Reza Nozari asl,

N. Jaafarzadeh, Faezeh Jahedi

и другие.

Annales de Toxicologie Analytique, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

6
Microplastics and Kidneys: An Update on the Evidence for Deposition of Plastic Microparticles in Human Organs, Tissues and Fluids and Renal Toxicity Concern DOI Open Access
Edoardo La Porta, Ottavia Exacoustos, Francesca Lugani

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(18), С. 14391 - 14391

Опубликована: Сен. 21, 2023

Plastic pollution became a main challenge for human beings as demonstrated by the increasing dispersion of plastic waste into environment. Microplastics (MPs) have become ubiquitous and humans are exposed daily to inhalation or ingestion microparticles. Recent studies performed using mainly spectroscopy spectrometry-based techniques shown astounding evidence presence MPs in tissues, organs fluids. The placenta, meconium, breast milk, lung, intestine, liver, heart cardiovascular system, blood, urine cerebrovascular liquid afflicted MPs’ deposition. On whole, obtained data underline great heterogeneity among different tissue polymers characterized microparticles’ dimension, even if most them seem be below 50–100 µm. Evidence possible contribution diseases is still limited this field study medicine an initial state. However, on their toxicity vitro vivo suggest worrying effects cells mediated oxidative stress, inflammation fibrosis. Nephrological insufficient kidneys lacking, but little present literature has histological functional alteration animal models cytotoxicity through apoptosis, autophagy, stress kidney cells. Overall, manuscript we report review recommends urgent further analyze potential correlations between disease exposure human.

Язык: Английский

Процитировано

30
Human Exposure to Ambient Atmospheric Microplastics in a Megacity: Spatiotemporal Variation and Associated Microorganism-Related Health Risk DOI
Libo Xu, Xinyi Bai, Kang Li

и другие.

Environmental Science & Technology, Год журнала: 2024, Номер 58(8), С. 3702 - 3713

Опубликована: Фев. 15, 2024

Microplastics are found in various human tissues and considered harmful, raising concerns about exposure to microplastics the environment. Existing research has analyzed indoor occupational scenarios, but long-term monitoring of ambient atmospheric (AMPs), especially highly polluted urban regions, needs be further investigated. This study estimated environmental AMPs by considering inhalation, dust ingestion, dermal three functional zones within a megacity. The annual quantity was 7.37 × 104 items for children 1.06 105 adults, comparable with microplastic consumption from food water. Significant spatiotemporal differences were observed characteristics that humans exposed to, wind speed rainfall frequency mainly driving these changes. AMP green land spaces, which recognized as relatively low zones, public service residential zones. Notably, significant positive correlations between pathogenicity airborne bacterial community discovered. size immune-mediated disease risks brought microbes showed most relationship, where Sphingomonas might act potential key mediator.

Язык: Английский

Процитировано

17
The Abundance of Microplastics in the World’s Oceans: A Systematic Review DOI Creative Commons
Judith Mutuku, MB Yanotti, Mark Tocock

и другие.

Oceans, Год журнала: 2024, Номер 5(3), С. 398 - 428

Опубликована: Июнь 21, 2024

Microplastics are ubiquitous in marine environments and have been documented across all ocean compartments, especially surface waters, the world. Even though several studies identify presence of microplastics world’s five oceans, there remains an overt problem large inconsistencies their sampling, extraction, consequent quantification. Despite complexity these methodologies, researchers tried to explore microplastic abundance waters. Using a systematic review approach, dataset was derived from 73 primary undertaken since year 2010 following Oslo Paris Conventions (OSPAR) guidelines monitor harmonise debris. The results showed differences distribution waters oceans. overall concentration oceans ranged between 0.002 62.50 items/m3, with mean 2.76 items/m3. highest found Atlantic (4.98 items/m3), while least observed Southern Ocean (0.04 items/m3). While challenging, this paper recommends harmonisation separation, identification methods globe aid design appropriate mitigation strategies for reducing plastic pollution.

Язык: Английский

Процитировано

14
Inhalation of Microplastics—A Toxicological Complexity DOI Creative Commons
Myriam Borgatta, Florian Breider

Toxics, Год журнала: 2024, Номер 12(5), С. 358 - 358

Опубликована: Май 11, 2024

Humans are chronically exposed to airborne microplastics (MPs) by inhalation. Various types of polymer particles have been detected in lung samples, which could pose a threat human health. Inhalation toxicological studies crucial for assessing the effects MPs and exposure-reduction measures. This communication paper addresses important health concerns related MPs, taking into consideration three levels complexity, i.e., themselves, additives present plastics, exogenous substances adsorbed onto them. approach aims obtain comprehensive profile deposited lungs, encompassing local systemic effects. The physicochemical characteristics may play pivotal role toxicity. Although evidence suggests toxic animal cell models, no established causal link with pulmonary or diseases humans has established. transfer associated chemicals from lungs bloodstream and/or circulation remains be confirmed humans. Understanding toxicity requires multidisciplinary investigation using One Health approach.

Язык: Английский

Процитировано

12