International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(6), P. 2536 - 2536
Published: March 12, 2025
Jasonia
glutinosa
(L.)
DC.,
commonly
known
in
Spain
as
“Rock
Tea”,
is
a
medicinal
plant
native
to
the
Iberian
Peninsula,
southern
France,
and
Morocco.
It
has
traditionally
been
used
digestive,
analgesic,
antimicrobial,
antidepressant,
or
for
respiratory
diseases.
This
narrative
review
aims
scientifically
validate
ethnopharmacological
uses
of
J.
plant,
emphasizing
relationship
between
its
traditional
applications,
pharmacological
activities,
mechanisms
action
based
on
experimental
evidence.
A
comprehensive
search
was
conducted
various
electronic
databases
gather
information
uses,
phytochemical
composition,
vitro,
ex
vivo,
vivo
studies
related
properties.
The
literature
uncovered
significant
findings
regarding
molecular
this
models,
particularly
highlighting
spasmolytic,
anti-inflammatory,
antioxidant
The Plant Journal,
Journal Year:
2021,
Volume and Issue:
107(5), P. 1299 - 1319
Published: June 25, 2021
Caffeoylquinic
acids
(CQAs)
are
specialized
plant
metabolites
we
encounter
in
our
daily
life.
Humans
consume
CQAs
mg-to-gram
quantities
through
dietary
consumption
of
products.
considered
beneficial
for
human
health,
mainly
due
to
their
anti-inflammatory
and
antioxidant
properties.
Recently,
new
biosynthetic
pathways
via
a
peroxidase-type
p-coumaric
acid
3-hydroxylase
enzyme
were
discovered.
More
recently,
GDSL
lipase-like
able
transform
monoCQAs
into
diCQA
was
identified
Ipomoea
batatas.
recently
linked
memory
improvement;
they
seem
be
strong
indirect
antioxidants
Nrf2
activation.
However,
there
is
prevalent
confusion
the
designation
nomenclature
different
CQA
isomers.
Such
inconsistencies
critical
complicate
bioactivity
assessment
since
isomers
differ
potency.
A
detailed
explanation
regarding
origin
such
provided,
recommendation
unify
suggested.
Furthermore,
studies
on
bioactivity,
plant-based
laboratory
animal
diets
contain
CQAs,
which
makes
it
difficult
include
proper
control
groups
comparison.
Therefore,
synthetic
diet
free
advised
avoid
interferences
some
may
produce
even
at
nanomolar
levels.
Biotransformation
by
gut
microbiota,
discovery
enzymatic
metabolic
pathways,
assessment,
biological
properties
with
potential
drug
development
areas
active,
ongoing
research.
This
review
focused
chemistry,
biosynthesis,
occurrence,
analytical
challenges,
reported
mono-,
di-,
tri-,
tetraCQAs.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(11), P. 3400 - 3400
Published: May 25, 2022
The
demand
of
foods
with
high
antioxidant
capacity
have
increased
and
research
on
these
continues
to
grow.
This
review
is
focused
chlorogenic
acids
(CGAs)
from
green
coffee,
which
the
most
abundant
source.
main
CGA
in
coffee
5-O-caffeoylquinic
acid
(5-CQA).
Coffee
extracts
are
currently
widely
used
source
enhance
activity
foods.
Due
solubility
CGAs,
their
extraction
mainly
performed
organic
solvents.
CGAs
been
associated
health
benefits,
such
as
antioxidant,
antiviral,
antibacterial,
anticancer,
anti-inflammatory
activity,
others
that
reduce
risk
cardiovascular
diseases,
type
2
diabetes,
Alzheimer’s
disease.
However,
biological
activities
depend
stability
sensitive
pH,
temperature,
light.
5-CQA
attributed
reducing
proinflammatory
cytokines.
can
negatively
affect
colon
microbiota.
An
increase
anthocyanins
was
observed
when
were
added
different
food
matrices
dairy
products,
drinks,
chocolate,
bakery
products.
fortification
has
potential
improve
functionality
Molecules,
Journal Year:
2023,
Volume and Issue:
28(14), P. 5540 - 5540
Published: July 20, 2023
Chlorogenic
and
isochlorogenic
acids
are
naturally
occurring
antioxidant
dietary
polyphenolic
compounds
found
in
high
concentrations
plants,
fruits,
vegetables,
coffee,
coffee
by-products.
The
objective
of
this
review
was
to
assess
the
potential
health
risks
associated
with
oral
consumption
by-products
containing
chlorogenic
acids,
considering
both
acute
chronic
exposure.
An
electronic
literature
search
conducted,
revealing
that
5-caffeoylquinic
acid
(5-CQA)
3,5-dicaffeoylquinic
(3,5-DCQA)
major
Toxicological,
pharmacokinetic,
clinical
data
from
animal
human
studies
were
available
for
assessment,
which
indicated
no
significant
evidence
toxic
or
adverse
effects
following
current
state
knowledge
suggests
long-term
exposure
by
daily
does
not
appear
pose
a
risk
when
observed
at
doses
within
normal
range
As
result,
intake
CQAs
can
be
considered
reasonably
safe.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(3), P. 355 - 355
Published: March 9, 2024
The
methods
and
solvents
employed
in
routine
extraction
protocols
essentially
impact
the
composition
of
resulting
extracts,
i.e.,
relative
abundances
individual
biologically
active
metabolites
quality
stability
isolates.
Natural
deep
eutectic
(NADESs)
represent
a
new
class
environmentally
friendly
solvents,
which
are
recognized
as
promising
extractants
alternative
to
conventional
organic
liquids.
However,
their
efficiencies
when
applied
different
workflows
still
poorly
characterized.
Therefore,
here,
we
compare
potential
three
for
natural
products
from
Aralia
elata
var.
mandshurica
with
selected
using
non-targeted
metabolomics
approach.
metabolite
profiling
relied
on
reversed-phase
ultra-high-performance
liquid
chromatography–high-resolution
mass
spectrometry
(RP-UHPLC-HR-MS).
roots
A.
were
extracted
by
maceration,
ultrasound-assisted
(UAE),
vibrocavitation-assisted
(VAE).
Principal
component
analysis
(PCA)
revealed
clear
separation
extracts
obtained
NADES1
(choline
chloride/malic
acid)
NADES2
(sorbitol/malic
acid/water).
Based
results
hierarchical
clustering
normalized
further
statistical
evaluation
t-test,
it
could
be
concluded
that
showed
superior
efficiency
all
addressed.
this
NADES
was
more
detail.
PCA
followed
t-test
yielded
only
3
efficiently
whereas
46
compounds
abundant
VAE.
When
VAE
UAE
compared,
108
appeared
VAE,
1
recovered
UAE.
These
facts
clearly
indicate
advantage
method
over
maceration
Seven
twenty-seven
tentatively
identified
tandem
(MS/MS)
found
first
time.
Additional
studies
necessary
understand
applicability
other
plant
materials.
Heliyon,
Journal Year:
2023,
Volume and Issue:
9(10), P. e20232 - e20232
Published: Sept. 15, 2023
Chrysanthemum
is
a
flowering
plant
belonging
to
genus
of
the
dicotyledonous
herbaceous
annual
Asteraceae
(Compositae)
family.
It
perpetual
plant,
mostly
cultivated
for
medicinal
purposes;
generally,
used
in
popular
drinks
due
its
aroma
and
flavor.
primarily
China,
Japan,
Europe,
United
States.
These
flowers
were
extensively
various
healthcare
systems
treating
diseases.
are
rich
phenolic
compounds
exhibit
strong
properties
including
antioxidant,
antimicrobial,
anti-inflammatory,
anticancer,
anti-allergic,
anti-obesity,
immune
regulation,
hepatoprotective,
nephroprotective
activities.
The
main
aim
present
review
was
investigate
nutritional
profile,
phytochemistry,
biological
activities
different
species.
Also,
critical
discussion
diverse
metabolites
or
bioactive
constituents
highlighted
review.
Moreover,
flower
extracts
have
been
assessed
possess
phytochemical
such
as
cyanidin-3-O-(6″-O-malonyl)
glucoside,
delphinidin
3-O-(6"
-O-malonyl)
glucoside-3′,
rutin,
quercetin,
isorhamnetin,
rutinoside,
others.
profiles
potential
health
benefits,
leading
their
utilization
production
supplementary
food
products
pharmaceutical
drugs
within
industry.
However,
more
comprehensive
research
studies/investigations
still
needed
further
discover
benefits
human
animal
utilization.
Journal of the European Academy of Dermatology and Venereology,
Journal Year:
2023,
Volume and Issue:
37(11), P. 2208 - 2221
Published: March 13, 2023
Vitiligo
is
a
common
chronic
skin
disease
which
has
an
adverse
impact
on
patients'
life.
Its
pathogenesis
complex,
involving
autoimmunity
and
oxidative
stress
(OS).
Autoimmunity
leads
to
the
loss
of
epidermal
melanocytes
formation
depigmented
patches
disease.
Treatment
vitiligo
should
control
exaggerated
immune
response
arrest
progress
active
disease,
then
promote
repigmentation.
Wnt/β-catenin
signalling
pathway
been
recent
interest
in
vitiligo.
downregulated
Upregulation
possibly
autoimmune
by
protecting
melanocyte
from
OS
damage,
inhibiting
CD8+
T
cell
effector
differentiation
enhancing
Treg.
plays
critical
role
regeneration
driving
stem
cells
(McSCs)
into
melanocytes.
Promoting
can
not
only
but
also
Some
main
effective
therapies
for
are
likely
work
activating
signalling.
Agents
that
enhance
effect
may
become
potential
candidates
development
new
drugs
treatment.
Cell Biochemistry and Function,
Journal Year:
2024,
Volume and Issue:
42(1)
Published: Jan. 1, 2024
Abstract
Conventional
treatment
methods
are
not
effective
enough
to
fight
the
rapid
increase
in
cancer
cases.
The
interest
is
increasing
investigation
of
herbal
sources
for
development
new
anticancer
therapeutics.
This
study
aims
investigate
antitumor
capacity
Hypericum
alpestre
(H.
alpestre)
extract
vitro
and
vivo,
either
alone
or
combination
with
inhibitors
l
‐arginine/polyamine/nitric
oxide
(NO)
pathway,
characterize
its
active
phytochemicals
using
advanced
chromatographic
techniques.
Our
previous
reports
suggest
beneficial
effects
arginase
inhibitor
NG‐hydroxy‐nor‐
‐arginine
NO
NG‐nitro‐Larginine
methyl
ester
breast
via
downregulation
polyamine
synthesis.
Here,
properties
H.
combinations
were
explored
a
rat
model
mammary
gland
carcinogenesis
induced
by
subcutaneous
injection
7,12‐dimethylbenz[a]anthracene.
revealed
strong
antiradical
activity
aerial
part
chemical
(DPPH/ABTS)
tests.
In
antioxidant
test,
demonstrated
pro‐oxidant
characteristics
human
colorectal
(HT29)
cells,
which
contingent
upon
hemostatic
condition
cells.
expressed
cytotoxic
effect
on
HT29
(MCF‐7)
cells
measured
MTT
test.
According
comet
assay
results,
did
exhibit
genotoxic
nor
possessed
antigenotoxic
Overall,
233
substances
have
been
identified
annotated
LC‐Q‐Orbitrap
HRMS
system.
vivo
experiments
models
that
activated
enzymes
liver,
brain,
tumors.
combined
chemotherapeutic
agents
attenuated
cancer‐like
histological
alterations
showed
significant
reductions
tumor
blood
vessel
area.
Thus,
N
ω
‐OH‐nor‐
‐nitro‐
ester,
exhibits
pro‐
antioxidant,
antiangiogenic,
effects.
Polymers,
Journal Year:
2021,
Volume and Issue:
13(11), P. 1727 - 1727
Published: May 25, 2021
Significant
problems
have
arisen
in
recent
years,
such
as
global
warming
and
hunger.
These
complications
are
related
to
the
depletion
exploitation
of
natural
resources,
well
environmental
pollution.
In
this
context,
bioprocesses
biorefinery
can
be
used
manage
agro-industrial
wastes
for
obtaining
high-value-added
products.
A
large
number
by-products
composed
lignin
cellulose,
having
potential
exploited
sustainably
chemical
biological
conversion.
The
has
applications
many
fields,
pharmaceuticals,
medicine,
material
engineering,
remediation.
comprehensive
approach
been
developed
toward
management
avocado
(Persea
americana)
biomass
waste,
which
transformed
into
products
mitigate
warming,
save
non-renewable
energy,
contribute
health
science.
Therefore,
work
presents
a
review
on
fruit
waste
its
possible
biofuel,
drugs,
bioplastics,
field,
emerging
nanotechnological
opportunities
economic
scientific
growth.
