Selenium deficiency exacerbated Bisphenol A-induced intestinal toxicity in chickens: Apoptosis and cell cycle arrest mediated by ROS/P53

The Science of The Total Environment, Год журнала: 2023, Номер 913, С. 169730 - 169730

Опубликована: Дек. 30, 2023

Язык: Английский

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Difenoconazole disrupts carp intestinal physical barrier and causes inflammatory response via triggering oxidative stress and apoptosis

Pesticide Biochemistry and Physiology, Год журнала: 2023, Номер 194, С. 105507 - 105507

Опубликована: Июнь 24, 2023

Язык: Английский

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Dietary selenomethionine reduced oxidative stress by resisting METTL3-mediated m6A methylation level of Nrf2 to ameliorate LPS-induced liver necroptosis in laying hens

The Journal of Nutritional Biochemistry, Год журнала: 2024, Номер 125, С. 109563 - 109563

Опубликована: Янв. 3, 2024

Язык: Английский

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Nootkatone Mitigated Melamine-Evoked Hepatotoxicity by Featuring Oxidative Stress and Inflammation Interconnected Mechanisms: In Vivo and In Silico Approaches

Toxics, Год журнала: 2023, Номер 11(9), С. 784 - 784

Опубликована: Сен. 15, 2023

Melamine (ML) is a common environmental contaminant, commonly used in food fraud, representing serious health hazard and jeopardizing human animal health. Recently, nootkatone (NK), naturally occurring sesquiterpenoid, has garnered considerable attention due to its potential therapeutic advantages. We investigated the mechanisms underlying protective effects of NK against ML-induced liver injury rats. Five groups were utilized: control, ML, NK10, ML-NK5, ML-NK10. ML induced substantial hepatotoxicity, including alterations biochemical parameters histology. The oxidative distress triggered by increased generation malondialdehyde (MDA) nitric oxide (NO) decreased levels reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) activities. In addition, expression nuclear factor-erythroid 2-related factor 2 (Nrf2) kappa beta (NF-κB) observed hepatocytes, which indicated occurrence inflammatory changes following exposure. These alleviated supplementation dose-dependent manner. data revealed that favorable attributed, at least part, antioxidant anti-inflammatory properties. Moreover, our results supported molecular docking studies good fit interactions between enzymes. Thus, current study demonstrated new additive for prevention or treatment toxicity.

Язык: Английский

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Hepatotoxicity of the Pesticide Avermectin Exposure to Freshwater-Farmed Carp: Evidence from In Vivo and In Vitro Research

Journal of Agricultural and Food Chemistry, Год журнала: 2023, Номер 71(51), С. 20654 - 20670

Опубликована: Дек. 13, 2023

Avermectin (AVM) is presently one of the most extensively employed insecticides across globe. A number toxicity research studies AVM have been carried out in freshwater-farmed carp; however, there are currently no on liver. This investigation aims to replicate an acute liver injury model induced by carp, subsequently analyzing adverse effects imposed nontarget species while delving into potential mechanisms underlying its toxicity. In this study, we found that AVM-exposed carp tissue showed cellular hydration degeneration and necrosis reduced viability hepatocyte L8824. Second, oxidative stress stimulation led reactive oxygen (ROS) accumulation Ca2+ overload L8824, suggesting exposure induces mitochondrial dysfunction hepatocytes. inflammation inducing kinetic disruption, which triggered hepatic injury. autophagy apoptosis ROS mediated AVM-induced apoptosis. The formation attenuated conclusion, present study elucidated hepatotoxicity freshwater aquaculture exposed pesticide AVM, emphasized importance monitoring contamination aquatic environments, provided theoretical references for targeted prevention carp.

Язык: Английский

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TBBPA causes apoptosis in grass carp hepatocytes involving destroyed ER-mitochondrial function

Chemosphere, Год журнала: 2023, Номер 341, С. 139974 - 139974

Опубликована: Авг. 27, 2023

Язык: Английский

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Probing Selenium-Deficient Chicken Spleen Th1/Th17 Differentiation Based on Selenoprotein W Targeting of PKM2/HIF1α

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(44), С. 24808 - 24822

Опубликована: Окт. 23, 2024

Selenium regulates the differentiation and function of immune cells mainly through selenoproteins. Selenoprotein W (SelW) has been shown to mitigate inflammatory bowel disease in mice by modulating helper T (CD4

Язык: Английский

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Elucidating the transcriptomic response of adult-derived mHypoA-2/12 mouse hypothalamic neuron cell line to cannabidiol (CBD) exposure

Journal of Applied Genetics, Год журнала: 2025, Номер unknown

Опубликована: Май 8, 2025

Abstract Cannabidiol (CBD) is a compound found in Cannabis sativa that known for its neuroprotective, anti-inflammatory, analgesic, and anxiolytic properties. These properties make it promising treatment various neurological conditions. This study aimed to examine the effects of CBD on hypothalamic neurons at transcriptome level using adult-derived mHypoA-2/12 mouse cell line. The cells were exposed four different concentrations (ranging from 0.325 3 µM) 6 24 h. Apart analysis, apoptosis (caspase 3/7 activity) viability (MTT) assays performed. obtained results showed enhanced viability, especially after h lower or intermediate concentrations, reduced apoptosis, with significant highest concentration. caused moderate profile changes (13 69 genes per treatment), more affected higher shorter exposure times, indicating stronger initial cellular response. Further analysis revealed affects several biological processes, including: intrinsic suppression via p53 modulation, impacting like Bbc3 , Mdm2 Cdkn1a Smad3 . Additionally, influenced involved extracellular matrix organization, including metalloproteinases ( Mmp-3 Mmp-13 ) their inhibitors Timp1 ), as well collagen components Col11a1 mitochondrial respiratory chain complexes mt-Nd5 mt-Nd4 ). Genes related serotonin dopamine biosynthesis, Aldh2 also impacted, linking CBD’s potential benefits managing alcohol use disorders. findings suggest hypothalamus target CBD, warranting further investigation.

Язык: Английский

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Resveratrol mitigates cold exposure-induced apoptosis and energy metabolism disorder in broiler heart by mediating the p38-PI3K/AKT-NF-κB axis

Journal of Thermal Biology, Год журнала: 2025, Номер 130, С. 104162 - 104162

Опубликована: Май 1, 2025

Язык: Английский

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Quantum-Enhanced Gradient Boosting Neural Networks for Optimizing PFOS Removal with Nanofiltration Membranes

Desalination and Water Treatment, Год журнала: 2025, Номер unknown, С. 101266 - 101266

Опубликована: Июнь 1, 2025

Язык: Английский

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