Zebrafish: A trending model for gut-brain axis investigation

Aquatic Toxicology, Год журнала: 2024, Номер 270, С. 106902 - 106902

Опубликована: Март 17, 2024

Язык: Английский

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The interplay between gut microbiota composition and dementia

Reviews in the Neurosciences, Год журнала: 2025, Номер unknown

Опубликована: Янв. 20, 2025

Abstract Recently, researchers have been interested in the potential connection between gut microbiota composition and various neuropsychological disorders. Dementia significantly affects socioeconomics of families. Gut is considered as a probable factor its pathogenesis. Multiple bacterial metabolites such short-chain fatty acids, lipopolysaccharides, neurotransmitters that are responsible for incidence progression dementia can be produced by microbiota. Various species Bifidobacterium breve , Akkermansia muciniphila Streptococcus thermophilus Escherichia coli Blautia hydrogenotrophica etc. implicated pathogenesis dementia. great target imitating or inhibiting their an adjunctive therapy based on role Therefore, some diets prevent decelerate altering composition. Moreover, probiotics modulate increasing beneficial bacteria reducing detrimental species. These therapeutic modalities novel methods probably safe effective. They enhance efficacy traditional medications improve cognitive function.

Язык: Английский

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Temporomandibular disorders and mental health: shared etiologies and treatment approaches

The Journal of Headache and Pain, Год журнала: 2025, Номер 26(1)

Опубликована: Март 12, 2025

The biopsychosocial model suggests that temporomandibular disorders (TMDs) often coexist with mental health disorders, particularly depression and anxiety, affecting a significant portion of the global population. interplay between TMDs contributes to complex comorbidity, perpetuating cycle mutual influence reinforcement. This review investigates neurobiological mechanisms epidemiological evidence supporting shared etiology exploring potential vulnerabilities bidirectional causal relationships. Shared may stem from genetic epigenetic predispositions, psychosocial factors, behavioral aspects. Inflammatory cytokines, neurotransmitters, neurotrophins, neuropeptides play pivotal roles in both peripheral central sensitization as well neuroinflammation. Brain imaging studies suggest exhibit overlapping brain regions indicative reward processing deficits anomalies within triple network model. Future research efforts are crucial for developing comprehensive understanding underlying confirming reciprocal effects disorders. provides valuable insights oral healthcare professionals, stressing importance optimizing treatment strategies individuals dealing concurrent issues through personalized, holistic, multidisciplinary approach.

Язык: Английский

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Fermented vegetables in China: overview, novel processes, influencing factors, lactic acid bacteria and industrialisation status

International Journal of Food Science & Technology, Год журнала: 2024, Номер 59(7), С. 4420 - 4436

Опубликована: Май 27, 2024

Summary Fermented vegetables are nutritionally beneficial and promote good health. China possesses abundant raw vegetable materials has a longstanding history of fermented production. However, the traditional process fermentation heavily relies on individual producers' experience knowledge, resulting in inconsistent flavours, variable quality, potential generation harmful substances. The utilisation lactic acid starters can effectively inhibit pathogenic bacteria during process, enhance product flavour, reduce nitrite production, improve functional nutritional value, as well extend shelf‐life. This article comprehensively reviews factors influencing fermentation; diverse functions performed by throughout assesses current industrialisation status China. It serves valuable reference for promoting high‐quality development within industry.

Язык: Английский

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Ginsenoside Re Prevents Depression-like Behaviors via Inhibition of Inflammation, Oxidative Stress, and Activating BDNF/TrkB/ERK/CREB Signaling: An In Vivo and In Vitro Study

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(36), С. 19838 - 19851

Опубликована: Авг. 26, 2024

Depression is a widespread disease, with high mortality and recurrence rates. Recent studies have shown that elevated cytokine levels are implicated in the molecular mechanisms of depression. Oxidative stress contributes to stimulation production. Growing evidence suggests ginsenoside Re (Gs-Re) exerts neuroprotective effect on hippocampus by suppressing oxidative inflammation. However, mechanism Gs-Re treatment depression remain understudied. This study aimed evaluate antidepressant-like effects possible underlying mechanisms. In this article, was studied both vitro (H

Язык: Английский

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Lacticaseibacillus rhamnosus KY16 Improves Depression by Promoting Intestinal Secretion of 5-HTP and Altering the Gut Microbiota

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Сен. 23, 2024

Increasing research suggests a connection between gut microbiota and depressive disorders. Targeted changes to the intestinal flora may contribute alleviating anxiety depression. This study aimed identify probiotics that could attenuate stress-induced abnormal behavior explore potential mechanisms. The administration of LR.KY16 significantly reduced behaviors physiological dysfunction. mechanism be via regulating structure in mice, increasing abundance

Язык: Английский

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The effect of prebiotic and probiotic food consumption on anxiety severity: a nationwide study in Korea

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Май 28, 2024

Over the past decade, research has reported that diet and gut health affect anxiety symptoms through changes in microbiota. Therefore, introduction of prebiotic probiotic food favorable for intestinal microbiota is necessary to improve mental host. The purpose this study was examine contribution foods lowering using a large, nationwide population-based database. population included 4,317 individuals 19 64 years age who participated Korean National Health Nutrition Examination Survey (KNHANES VII-3, 2019-2021). A frequency questionnaire used evaluate consumption. Generalized Anxiety Disorder Assessment 7-item scale (GAD-7) assessed severity symptoms. effect consumption on analyzed multiple logistic regression. symptom significantly lower highest and/or tertiles compared lowest tertile. We also found sex difference odds ratio associated with among both men women. However, had significant beneficial but not Our finding suggests might confer influence Further required deeper understanding into mechanisms positive effects prebiotics probiotics anxiety.

Язык: Английский

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Mechanisms of microbiota-gut-brain axis communication in anxiety disorders

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Дек. 9, 2024

Anxiety disorders, prevalent mental health conditions, receive significant attention globally due to their intricate etiology and the suboptimal effectiveness of existing therapies. Research is increasingly recognizing that genesis anxiety involves not only neurochemical brain alterations but also changes in gut microbiota. The microbiota-gut-brain axis (MGBA), serving as a bidirectional communication pathway between microbiota central nervous system (CNS), at forefront novel approaches deciphering complex pathophysiology disorders. This review scrutinizes role recent advancements MGBA concerning disorders through literature, emphasizing mechanisms via neural signals, endocrine pathways, immune responses. evidence robustly supports critical influence both development progression these Furthermore, this discussion explores potential therapeutic avenues stemming from insights, alongside challenges issues present realm. Collectively, our findings aim enhance understanding pathological foster improved preventative strategies for

Язык: Английский

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Morinda officinalis oligosaccharides alleviate chronic unpredictable mild stress-induced depression through the BDNF/TrkB/CREB pathway and symptoms of sexual dysfunction in mice

Frontiers in Neuroscience, Год журнала: 2025, Номер 18

Опубликована: Янв. 8, 2025

In recent years, depression has become a global public health concern, and one of the common concomitant symptoms are diminished sexual motivation impaired performance. The aim this study was to investigate potential effects Morinda officinalis oligosaccharides (MOO) on its symptom, dysfunction. Chronic unpredictable mild stress (CUMS)-induced model constructed, MOO abilities were evaluated. results revealed that able alleviate CUMS-induced depression-like behavior in mice, inhibit hippocampal neuron apoptosis, reverse monoamine neurotransmitter imbalance, increase Brain-derived neurotrophic factor (BDNF) expression levels hippocampus, modulate composition distribution gut microbiota, abundance probiotics after continuous gavage for 28 days. further confirmed dysfunction is closely related development by improving lack low performance depressed modulating disruption sex hormone secretion serum, alleviating sperm morphology functional defects epididymis. These findings provide basis exploring antidepressant mechanism, use improve hypogonadotropic symptoms, future new drug improves symptoms.

Язык: Английский

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Electroacupuncture Neural Stimulation Mitigates Bladder Dysfunction and Mechanical Allodynia in Cyclophosphamide Induced Cystitis through Downregulation of the BDNF-TrkB Signaling Pathway

eNeuro, Год журнала: 2025, Номер 12(3), С. ENEURO.0329 - 24.2025

Опубликована: Март 1, 2025

Central sensitization plays a critical role in bladder pain syndrome/interstitial cystitis (BPS/IC). Electroacupuncture (EA) nerve stimulation therapy has been broadly acknowledged as an effective means of alleviating chronic pathological pain. However, it remains to be explored whether EA is mitigating pain-sensitive symptoms BPS/IC and the mechanisms involved. This study aims investigate analgesic effect mechanism therapy. To achieve this goal, we employed several techniques: mechanical threshold tests assess sensitivity, urodynamic studies evaluate function, Western blotting (WB) for protein analysis, immunofluorescence visualizing, transcriptomics. A rat model was established through systemic intraperitoneal injection with cyclophosphamide (CYP). executed by stimulating deep part hypochondriac point, where 2nd-4th sacral nerves traverse. treatment observed effectively reduce allodynia, enhance urinary suppress activation microglial cells, alleviate neuroinflammation. Additionally, demonstrated capability downregulate BDNF-TrkB signal transduction spinal dorsal horn. Transcriptome sequencing indicated that potentially inhibits excitatory neural transmission modulates pathways related longevity. Furthermore, shown efficacy treating conditions such Huntington's disease, amyotrophic lateral sclerosis, prion diseases. In conclusion, regulating signaling, can dysfunction allodynia cyclophosphamide-induced model. Our research elucidates underlying offers new theoretical insights addressing painful BPS.Significance Statement major factor (BPS/IC), making management crucial. explores potential electroacupuncture therapeutic approach improve function induced cyclophosphamide. findings demonstrate significantly reduces enhances decreases neuroinflammation modulating signaling The highlights EA's inhibit provide relief conditions. These results offer into therapy, improving strategies similar syndromes.

Язык: Английский

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