Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(12), P. 2905 - 2905
Published: Dec. 20, 2024
(1)
Background:
Gamma-aminobutyric
acid
(GABA)
is
an
amino
and
the
primary
inhibitory
neurotransmitter
in
brain.
GABA
has
been
shown
to
reduce
stress
promote
sleep.
GABALAGEN
(GBL)
product
of
fermented
fish
collagen
by
Lactobacillus
brevis
BJ20
plantarum
BJ21,
naturally
enriched
with
through
fermentation
process
characterized
low
molecular
weight.
(2)
Methods:
The
present
study
evaluated
GABAA
affinity
GBL
receptor
binding
assay.
sedative
effects
were
investigated
electroencephalography
(EEG)
analysis
animal
model
electro
foot
shock
(EFS)
stress-induced
sleep
disorder,
then
we
examined
expression
orexin
brain
region
using
immunohistochemistry
enzyme-linked
immunosorbent
assay
(ELISA).
(3)
Results:
We
found
that
on
assay,
displayed
high
receptor.
Also,
after
treatment
GBL,
percentage
total
time
rapid
eye
movement
(REM)
non-rapid
(NREM)
was
significantly
dose-dependently
increased
EFS-induced
rats.
Consistent
behavioral
results,
GBL-treated
groups
showed
immune-positive
cells
VLPO
markedly
increased.
orexin-A
level
LH
decreased.
(4)
Conclusions:
efficacy
potential
be
used
as
anti-stress
therapy
treat
deprivation
stimulation
receptors
consequent
inhibition
activity.
Reviews in the Neurosciences,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 20, 2025
Abstract
Recently,
researchers
have
been
interested
in
the
potential
connection
between
gut
microbiota
composition
and
various
neuropsychological
disorders.
Dementia
significantly
affects
socioeconomics
of
families.
Gut
is
considered
as
a
probable
factor
its
pathogenesis.
Multiple
bacterial
metabolites
such
short-chain
fatty
acids,
lipopolysaccharides,
neurotransmitters
that
are
responsible
for
incidence
progression
dementia
can
be
produced
by
microbiota.
Various
species
Bifidobacterium
breve
,
Akkermansia
muciniphila
Streptococcus
thermophilus
Escherichia
coli
Blautia
hydrogenotrophica
etc.
implicated
pathogenesis
dementia.
great
target
imitating
or
inhibiting
their
an
adjunctive
therapy
based
on
role
Therefore,
some
diets
prevent
decelerate
altering
composition.
Moreover,
probiotics
modulate
increasing
beneficial
bacteria
reducing
detrimental
species.
These
therapeutic
modalities
novel
methods
probably
safe
effective.
They
enhance
efficacy
traditional
medications
improve
cognitive
function.
International Journal of Food Science & Technology,
Journal Year:
2024,
Volume and Issue:
59(7), P. 4420 - 4436
Published: May 27, 2024
Summary
Fermented
vegetables
are
nutritionally
beneficial
and
promote
good
health.
China
possesses
abundant
raw
vegetable
materials
has
a
longstanding
history
of
fermented
production.
However,
the
traditional
process
fermentation
heavily
relies
on
individual
producers'
experience
knowledge,
resulting
in
inconsistent
flavours,
variable
quality,
potential
generation
harmful
substances.
The
utilisation
lactic
acid
starters
can
effectively
inhibit
pathogenic
bacteria
during
process,
enhance
product
flavour,
reduce
nitrite
production,
improve
functional
nutritional
value,
as
well
extend
shelf‐life.
This
article
comprehensively
reviews
factors
influencing
fermentation;
diverse
functions
performed
by
throughout
assesses
current
industrialisation
status
China.
It
serves
valuable
reference
for
promoting
high‐quality
development
within
industry.
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
72(36), P. 19838 - 19851
Published: Aug. 26, 2024
Depression
is
a
widespread
disease,
with
high
mortality
and
recurrence
rates.
Recent
studies
have
shown
that
elevated
cytokine
levels
are
implicated
in
the
molecular
mechanisms
of
depression.
Oxidative
stress
contributes
to
stimulation
production.
Growing
evidence
suggests
ginsenoside
Re
(Gs-Re)
exerts
neuroprotective
effect
on
hippocampus
by
suppressing
oxidative
inflammation.
However,
mechanism
Gs-Re
treatment
depression
remain
understudied.
This
study
aimed
evaluate
antidepressant-like
effects
possible
underlying
mechanisms.
In
this
article,
was
studied
both
vitro
(H
Frontiers in Neuroscience,
Journal Year:
2025,
Volume and Issue:
18
Published: Jan. 8, 2025
In
recent
years,
depression
has
become
a
global
public
health
concern,
and
one
of
the
common
concomitant
symptoms
are
diminished
sexual
motivation
impaired
performance.
The
aim
this
study
was
to
investigate
potential
effects
Morinda
officinalis
oligosaccharides
(MOO)
on
its
symptom,
dysfunction.
Chronic
unpredictable
mild
stress
(CUMS)-induced
model
constructed,
MOO
abilities
were
evaluated.
results
revealed
that
able
alleviate
CUMS-induced
depression-like
behavior
in
mice,
inhibit
hippocampal
neuron
apoptosis,
reverse
monoamine
neurotransmitter
imbalance,
increase
Brain-derived
neurotrophic
factor
(BDNF)
expression
levels
hippocampus,
modulate
composition
distribution
gut
microbiota,
abundance
probiotics
after
continuous
gavage
for
28
days.
further
confirmed
dysfunction
is
closely
related
development
by
improving
lack
low
performance
depressed
modulating
disruption
sex
hormone
secretion
serum,
alleviating
sperm
morphology
functional
defects
epididymis.
These
findings
provide
basis
exploring
antidepressant
mechanism,
use
improve
hypogonadotropic
symptoms,
future
new
drug
improves
symptoms.
eNeuro,
Journal Year:
2025,
Volume and Issue:
12(3), P. ENEURO.0329 - 24.2025
Published: March 1, 2025
Central
sensitization
plays
a
critical
role
in
bladder
pain
syndrome/interstitial
cystitis
(BPS/IC).
Electroacupuncture
(EA)
nerve
stimulation
therapy
has
been
broadly
acknowledged
as
an
effective
means
of
alleviating
chronic
pathological
pain.
However,
it
remains
to
be
explored
whether
EA
is
mitigating
pain-sensitive
symptoms
BPS/IC
and
the
mechanisms
involved.
This
study
aims
investigate
analgesic
effect
mechanism
therapy.
To
achieve
this
goal,
we
employed
several
techniques:
mechanical
threshold
tests
assess
sensitivity,
urodynamic
studies
evaluate
function,
Western
blotting
(WB)
for
protein
analysis,
immunofluorescence
visualizing,
transcriptomics.
A
rat
model
was
established
through
systemic
intraperitoneal
injection
with
cyclophosphamide
(CYP).
executed
by
stimulating
deep
part
hypochondriac
point,
where
2nd-4th
sacral
nerves
traverse.
treatment
observed
effectively
reduce
allodynia,
enhance
urinary
suppress
activation
microglial
cells,
alleviate
neuroinflammation.
Additionally,
demonstrated
capability
downregulate
BDNF-TrkB
signal
transduction
spinal
dorsal
horn.
Transcriptome
sequencing
indicated
that
potentially
inhibits
excitatory
neural
transmission
modulates
pathways
related
longevity.
Furthermore,
shown
efficacy
treating
conditions
such
Huntington's
disease,
amyotrophic
lateral
sclerosis,
prion
diseases.
In
conclusion,
regulating
signaling,
can
dysfunction
allodynia
cyclophosphamide-induced
model.
Our
research
elucidates
underlying
offers
new
theoretical
insights
addressing
painful
BPS.Significance
Statement
major
factor
(BPS/IC),
making
management
crucial.
explores
potential
electroacupuncture
therapeutic
approach
improve
function
induced
cyclophosphamide.
findings
demonstrate
significantly
reduces
enhances
decreases
neuroinflammation
modulating
signaling
The
highlights
EA's
inhibit
provide
relief
conditions.
These
results
offer
into
therapy,
improving
strategies
similar
syndromes.
The Journal of Headache and Pain,
Journal Year:
2025,
Volume and Issue:
26(1)
Published: March 12, 2025
The
biopsychosocial
model
suggests
that
temporomandibular
disorders
(TMDs)
often
coexist
with
mental
health
disorders,
particularly
depression
and
anxiety,
affecting
a
significant
portion
of
the
global
population.
interplay
between
TMDs
contributes
to
complex
comorbidity,
perpetuating
cycle
mutual
influence
reinforcement.
This
review
investigates
neurobiological
mechanisms
epidemiological
evidence
supporting
shared
etiology
exploring
potential
vulnerabilities
bidirectional
causal
relationships.
Shared
may
stem
from
genetic
epigenetic
predispositions,
psychosocial
factors,
behavioral
aspects.
Inflammatory
cytokines,
neurotransmitters,
neurotrophins,
neuropeptides
play
pivotal
roles
in
both
peripheral
central
sensitization
as
well
neuroinflammation.
Brain
imaging
studies
suggest
exhibit
overlapping
brain
regions
indicative
reward
processing
deficits
anomalies
within
triple
network
model.
Future
research
efforts
are
crucial
for
developing
comprehensive
understanding
underlying
confirming
reciprocal
effects
disorders.
provides
valuable
insights
oral
healthcare
professionals,
stressing
importance
optimizing
treatment
strategies
individuals
dealing
concurrent
issues
through
personalized,
holistic,
multidisciplinary
approach.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(8), P. 3554 - 3554
Published: April 10, 2025
Obesity
is
characterized
by
an
excessive
imbalance
in
energy
metabolism
and
associated
with
metabolic
syndrome.
Mammals
have
two
types
of
adipose
tissue:
white
tissue
(WAT)
brown
(BAT).
These
are
key
factors
regulating
the
balance.
Strategies
aimed
at
reducing
obesity
should
encompass
not
only
prevention
lipid
accumulation
but
also
stimulation
browning
both
WAT
BAT,
aim
enhancing
expenditure.
In
this
study,
mechanism
which
Lactobacillus
brevis-fermented
gamma-aminobutyric
acid
(LB-GABA)
prevents
was
investigated,
as
well
whether
it
induces
lipolysis
using
3T3-L1
adipocytes.
The
expression
proteins
involved
signaling
pathways
degradation,
browning,
measured
Western
blotting
analysis.
We
demonstrated
that
LB-GABA
significantly
inhibited
suppressing
adipogenesis
lipogenesis.
addition,
microscopic
analysis
reduced
adipocyte
size
number
droplets.
Moreover,
blot
revealed
GABA
increased
activated
protein
kinase
A
(PKA)
pathway,
promotes
uncoupling
1
(UCP1)-mediated
browning.
conclusion,
these
results
suggest
activates
expenditure
through
regulation
exerts
anti-obesity
effects.
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 23, 2024
Increasing
research
suggests
a
connection
between
gut
microbiota
and
depressive
disorders.
Targeted
changes
to
the
intestinal
flora
may
contribute
alleviating
anxiety
depression.
This
study
aimed
identify
probiotics
that
could
attenuate
stress-induced
abnormal
behavior
explore
potential
mechanisms.
The
administration
of
LR.KY16
significantly
reduced
behaviors
physiological
dysfunction.
mechanism
be
via
regulating
structure
in
mice,
increasing
abundance
