Nanomaterials for cancer therapy: current progress and perspectives

Journal of Hematology & Oncology, Год журнала: 2021, Номер 14(1)

Опубликована: Май 31, 2021

Abstract Cancer is a disease with complex pathological process. Current chemotherapy faces problems such as lack of specificity, cytotoxicity, induction multi-drug resistance and stem-like cells growth. Nanomaterials are materials in the nanorange 1–100 nm which possess unique optical, magnetic, electrical properties. used cancer therapy can be classified into several main categories. Targeting cells, tumor microenvironment, immune system, these nanomaterials have been modified for wide range therapies to overcome toxicity enhance drug capacity well bioavailability. Although number studies has increasing, approved nano-drugs not increased much over years. To better improve clinical translation, further research needed targeted delivery by nano-carriers reduce toxicity, permeability retention effects, minimize shielding effect protein corona. This review summarizes novel fabricated use, discusses current limitations obstacles that hinder translation from provides suggestions more efficient adoption therapy.

Язык: Английский

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Recent development of gold(i) and gold(iii) complexes as therapeutic agents for cancer diseases

Chemical Society Reviews, Год журнала: 2022, Номер 51(13), С. 5518 - 5556

Опубликована: Янв. 1, 2022

In this review, the recent progress in gold( i ) and iii complexes are comprehensively summarized, their anti-cancer activity mechanism of action documented.

Язык: Английский

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Gold Complexes in Anticancer Therapy: From New Design Principles to Particle‐Based Delivery Systems

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(22)

Опубликована: Фев. 27, 2023

Abstract The discovery of the medicinal properties gold complexes has fuelled design and synthesis new anticancer metallodrugs, which have received special attention due to their unique modes action. Current research in development compounds with therapeutic is predominantly focused on molecular drug leads superior pharmacological activities, e.g., by introducing targeting features. Moreover, intensive aims at improving physicochemical compounds, such as chemical stability solubility physiological environment. In this regard, encapsulation nanocarriers or grafting onto targeted delivery vectors could lead nanomedicines that eventually reach clinical applications. Herein, we provide an overview state‐of‐the‐art progress andmore importantly thoroughly revise nanoparticle‐based systems for chemotherapeutics.

Язык: Английский

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Next Generation Gold Drugs and Probes: Chemistry and Biomedical Applications

Chemical Reviews, Год журнала: 2023, Номер 123(10), С. 6612 - 6667

Опубликована: Апрель 18, 2023

The gold drugs, sodium thiomalate (Myocrisin), aurothioglucose (Solganal), and the orally administered auranofin (Ridaura), are utilized in modern medicine for treatment of inflammatory arthritis including rheumatoid juvenile arthritis; however, new agents have been slow to enter clinic. Repurposing different disease indications such as cancer, parasitic, microbial infections clinic has provided impetus development complexes biomedical applications based on unique mechanistic insights differentiated from auranofin. Various chemical methods preparation physiologically stable associated mechanisms explored biomedicine therapeutics or probes. In this Review, we discuss chemistry next generation which encompasses oxidation states, geometry, ligands, coordination, organometallic compounds infectious diseases, inflammation, tools biology via gold-protein interactions. We will focus within past decade. Review provides readers with an accessible overview utility, development, mechanism action gold-based small molecules establish context basis thriving resurgence medicine.

Язык: Английский

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Designing a Mitochondria-Targeted Theranostic Cyclometalated Iridium(III) Complex: Overcoming Cisplatin Resistance and Inhibiting Tumor Metastasis through Necroptosis and Immune Response

Journal of Medicinal Chemistry, Год журнала: 2024, Номер 67(5), С. 3843 - 3859

Опубликована: Март 5, 2024

To develop a potential theranostic metal agent to reverse the resistance of cancer cells cisplatin and effectively inhibit tumor growth metastasis, we proposed design cyclometalated iridium (Ir) complex based on properties environment (TME). end, designed synthesized series Ir(III) 2-hydroxy-1-naphthaldehyde thiosemicarbazone complexes by modifying hydrogen atom(s) N-3 position compounds structure dimers then investigated their structure–activity structure–fluorescence relationships obtain an (Ir5) with remarkable fluorescence cytotoxicity cells. Ir5 not only possesses mitochondria-targeted but also overcomes inhibits metastasis in vivo. Besides, confirmed anticancer mechanisms acting different components TME: directly killing liver inducing necroptosis activating necroptosis-related immune response.

Язык: Английский

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Developing a Copper(II) Isopropyl 2-Pyridyl Ketone Thiosemicarbazone Compound Based on the IB Subdomain of Human Serum Albumin–Indomethacin Complex: Inhibiting Tumor Growth by Remodeling the Tumor Microenvironment

Journal of Medicinal Chemistry, Год журнала: 2024, Номер 67(7), С. 5744 - 5757

Опубликована: Март 29, 2024

To develop a next-generation metal agent and dual-agent multitargeted combination therapy, we developed copper (Cu) compound based on the properties of human serum albumin (HSA)–indomethacin (IND) complex to remodel tumor microenvironment (TME). We optimized series Cu(II) isopropyl 2-pyridyl ketone thiosemicarbazone compounds obtain (C4) with significant cytotoxicity then constructed an HSA–IND–C4 (HSA–IND–C4) delivery system. IND C4 bind hydrophobic cavities IB IIA domains HSA, respectively. In vivo, not only showed enhanced antitumor efficacy relative + but also improved their targeting ability decreased side effects. The mechanism involved acting different components TME. inhibited tumor-related inflammation, while induced apoptosis autophagy cancer cells angiogenesis.

Язык: Английский

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Pt(II) and Au(III) complexes containing Schiff-base ligands: A promising source for antitumor treatment

European Journal of Medicinal Chemistry, Год журнала: 2020, Номер 211, С. 113098 - 113098

Опубликована: Дек. 11, 2020

Язык: Английский

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Pt(II)-NHC Complex Induces ROS-ERS-Related DAMP Balance to Harness Immunogenic Cell Death in Hepatocellular Carcinoma

Journal of Medicinal Chemistry, Год журнала: 2022, Номер 65(3), С. 1848 - 1866

Опубликована: Янв. 13, 2022

Immunogenic cell death (ICD) can engage a specific immune response and establish long-term immunity in hepatocellular carcinoma (HCC). Herein, we design synthesize series of Pt(II)-N-heterocyclic carbene (Pt(II)-NHC) complexes derived from 4,5-diarylimidazole, which show strong anticancer activities vitro. Among them, 2c displays much higher than cisplatin other Pt(II)-NHC complexes, especially HCC cancer cells. In addition, find that is type II ICD inducer, successfully induce endoplasmic reticulum stress (ERS) accompanied by reactive oxygen species (ROS) generation finally lead to the release damage-associated molecular patterns (DAMPs) Importantly, shows great anti-HCC potential vaccination mouse model leads vivo activation CCl4-induced liver injury model.

Язык: Английский

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Developing a Copper(II) Agent Based on His-146 and His-242 Residues of Human Serum Albumin Nanoparticles: Integration To Overcome Cisplatin Resistance and Inhibit the Metastasis of Nonsmall Cell Lung Cancer

Journal of Medicinal Chemistry, Год журнала: 2022, Номер 65(13), С. 9447 - 9458

Опубликована: Июль 4, 2022

To overcome the resistance of nonsmall cell lung cancer (NSCLC) cells to cisplatin and inhibit their metastasis, we proposed develop a Cu(II) agent based on specific residue(s) HSA nanoparticles (NPs) for multitargeting tumor microenvironment (TME). this end, not only synthesized four 2-hydroxy-3-methoxybenzaldehyde thiosemicarbazone compounds (C1–C4), obtaining Cu compound (C4) with significant cytotoxicity by studying structure–activity relationships, but also revealed binding mechanism C4 through X-ray crystallography confirmed successful construction new HSA-C4 NPs delivery system. inhibited A549cisR growth optimized anticancer behavior C4. We further C4/HSA-C4 NP TME resistance: killing acting mtDNA inducing apoptosis, polarizing M2-type macrophages M1-type, inhibiting angiogenesis.

Язык: Английский

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A Brain‐Targeting NIR‐II Ferroptosis System: Effective Visualization and Oncotherapy for Orthotopic Glioblastoma

Advanced Science, Год журнала: 2023, Номер 10(13)

Опубликована: Март 3, 2023

Near-infrared-II (NIR-II) ferroptosis activators offer promising potentials in vivo theranostics of deep tumors, such as glioma. However, most cases are nonvisual iron-based systems that blind for precise theranostic study. Additionally, the iron species and their associated nonspecific activations might trigger undesired detrimental effects on normal cells. Considering gold (Au) is an essential cofactor life it can specifically bind to tumor cells, Au(I)-based NIR-II nanoparticles (TBTP-Au NPs) brain-targeted orthotopic glioblastoma innovatively constructed. It achieves real-time visual monitoring both BBB penetration targeting processes. Moreover, first validated released TBTP-Au activates effective heme oxygenase-1-regulated glioma cells greatly extend survival time glioma-bearing mice. This new mechanism based Au(I) may open a way fabrication advanced high-specificity anticancer drugs clinical trials.

Язык: Английский

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