Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

Journal of Hematology & Oncology, Год журнала: 2022, Номер 15(1)

Опубликована: Сен. 12, 2022

Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving therapeutic potential various agents and bioactive molecules through enhanced permeability retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective tumor cells utilizing cell surface-specific receptors, vasculature antigens high accuracy affinity. Additionally, stimuli-responsive nanoplatforms also been as a promising strategy against tumors, these maintain their stealth feature under conditions, but upon homing cancerous lesions or microenvironment, are responsive release cargoes. In this review, we comprehensively summarize field active number studies context emerging nanoplatform development, discuss how knowledge contribute further improvements clinical practice.

Язык: Английский

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Smart Nanomaterials in Cancer Theranostics: Challenges and Opportunities

ACS Omega, Год журнала: 2023, Номер 8(16), С. 14290 - 14320

Опубликована: Апрель 10, 2023

Cancer is ranked as the second leading cause of death globally. Traditional cancer therapies including chemotherapy are flawed, with off-target and on-target toxicities on normal cells, requiring newer strategies to improve cell selective targeting. The application nanomaterial has been extensively studied explored chemical biology tools in theranostics. It shows greater applications toward stability, biocompatibility, increased permeability, resulting precise targeting, mitigating shortcomings traditional therapies. nanoplatform offers an exciting opportunity gain targeting multifunctionality. advent nanotechnology, particular development smart nanomaterials, transformed diagnosis treatment. large surface area nanoparticles enough encapsulate many molecules ability functionalize various biosubstrates such DNA, RNA, aptamers, antibodies, which helps theranostic action. Comparatively, biologically derived nanomaterials perceive advantages over produced by conventional methods terms economy, ease production, reduced toxicity. present review summarizes techniques theranostics emphasizes (such organic (NPs), inorganic NPs, carbon-based NPs). We also critically discussed challenges impeding their translation treatment diagnostic applications. This concludes that use could significantly will facilitate new dimensions for tumor detection therapy.

Язык: Английский

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A Review on Polymer and Lipid-Based Nanocarriers and Its Application to Nano-Pharmaceutical and Food-Based Systems

Frontiers in Nutrition, Год журнала: 2021, Номер 8

Опубликована: Дек. 1, 2021

Recently, owing to well-controlled release, enhanced distribution and increased permeability, nanocarriers used for alternative drug food-delivery strategies have received increasingly attentions. Nanocarriers attracted a large amount of interest as potential carriers various bioactive molecules multiple applications. Drug food-based delivery via polymeric-based lipid-based has been widely investigated. Nanocarriers, especially liposomes, are more in the area novel nano-pharmaceutical or design. Herein, we aimed discuss recent advancement different surface-engineered type, along with cutting-edge applications food nanomedicine highlight phytochemical nanocarrier. Additionally, safety concern was also highlighted.

Язык: Английский

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Multifunctional metal-organic framework (MOF)-based nanoplatforms for cancer therapy: from single to combination therapy

Theranostics, Год журнала: 2022, Номер 13(1), С. 295 - 323

Опубликована: Дек. 19, 2022

Cancer remains a severe threat to human health. To date, although various therapeutic methods, including radiotherapy (RT), chemotherapy, chemodynamic therapy (CDT), phototherapy, starvation therapy, and immunotherapy, have entered new stage of rapid progress in cancer theranostics, their limited effect significant side effects need be considered carefully. With the development nanotechnology, marriage nanomaterials methods provides practical possibility improve deficiencies therapy. Notably, metal-organic frameworks (MOFs) composed ions/clusters bridging ligands through coordination bonds been widely applied deal with drawbacks different such as effects, low stability, poor efficacy, owing controllable morphologies, tailorable diameters, diverse compositions, tunable porosities, high specific surface areas, facile functionalization, good biocompatibility. This review summarizes recent advanced developments achievements multifunctional MOF-based nanoplatforms for single RT, CDT, phototherapy (photodynamic photothermal therapy), combination methods. Moreover, prospects challenges used tumor are also discussed.

Язык: Английский

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Green synthesis of bimetallic ZnO–CuO nanoparticles and their cytotoxicity properties

Scientific Reports, Год журнала: 2021, Номер 11(1)

Опубликована: Дек. 6, 2021

In this study, a simple and green strategy was reported to prepare bimetallic nanoparticles (NPs) by the combination of zinc oxide (ZnO) copper (CuO) using Sambucus nigra L. extract. The physicochemical properties these NPs such as crystal structure, size, morphology were studied X-ray diffraction (XRD), field emission gun scanning electron microscopy (FEG-SEM), transmission (TEM). results suggested that contained polygonal ZnO with hexagonal phase spherical CuO monoclinic phase. anticancer activity prepared evaluated against lung human melanoma cell lines based on MTT assay. As result, ZnO/CuO exhibited high toxicity cancer cells while their low.

Язык: Английский

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Overcoming Cancer Multi-drug Resistance (MDR): Reasons, mechanisms, nanotherapeutic solutions, and challenges

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 162, С. 114643 - 114643

Опубликована: Апрель 7, 2023

Multi-drug resistance (MDR) in cancer cells, either intrinsic or acquired through various mechanisms, significantly hinders the therapeutic efficacy of drugs. Typically, reduced performance drugs is predominantly due to inherent over expression ATP-binding cassette (ABC) transporter proteins on cell membrane, resulting deprived uptake drugs, augmenting drug detoxification, and DNA repair. In addition physiological abnormalities extensive blood flow, MDR phenotypes exhibit improved apoptotic threshold efflux efficiency. These severe consequences have substantially directed researchers fabrication advanced strategies, such as co-delivery along with generations inhibitors, augmented dosage regimens frequency administration, well combinatorial treatment options, among others. this review, we emphasize different reasons mechanisms responsible for cancer, including but not limited known mediated by permeability glycoprotein (P-gp) other pumps, uptake, altered repair, targets, Further, an emphasis specific cancers that share pathogenesis executing effluxed common provided. Then, aspects related nanomaterials-based supramolecular programmable designs (organic- inorganic-based materials), physical approaches (light- ultrasound-based therapies), are discussed, highlighting unsolved issues future advancements. Finally, summarize review interesting perspectives trends, exploring further opportunities overcome MDR.

Язык: Английский

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Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Фев. 21, 2024

Abstract Inflammation-associated diseases encompass a range of infectious and non-infectious inflammatory diseases, which continuously pose one the most serious threats to human health, attributed factors such as emergence new pathogens, increasing drug resistance, changes in living environments lifestyles, aging population. Despite rapid advancements mechanistic research development for these current treatments often have limited efficacy notable side effects, necessitating more effective targeted anti-inflammatory therapies. In recent years, nanotechnology has provided crucial technological support prevention, treatment, detection inflammation-associated diseases. Various types nanoparticles (NPs) play significant roles, serving vaccine vehicles enhance immunogenicity carriers improve targeting bioavailability. NPs can also directly combat pathogens inflammation. addition, facilitated biosensors pathogen imaging techniques This review categorizes characterizes different NPs, summarizes their applications It discusses challenges associated with clinical translation this field explores latest developments prospects. conclusion, opens up possibilities comprehensive management

Язык: Английский

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Scale-up polymeric-based nanoparticles drug delivery systems: Development and challenges

OpenNano, Год журнала: 2022, Номер 7, С. 100048 - 100048

Опубликована: Май 28, 2022

The development of nanotechnology as a crucial technology in recent years has resulted new and creative nanomedicine applications. characteristics are determined by size, surface, drug loading, targeting potential combination with diagnostic agents for therapeutic applications to form nano multifunctional devices. Nanomedicine provides healthcare paradigm is capable revitalizing existing clinical products. Polymeric nanoparticles (PNPs) promising nanomedicines. With increasing demands medical, pharmaceutical, or nutritional applications, (NPs) require high reproducibility, homogeneity, control over their properties; upscaling processes unavoidable. Conventional small-scale laboratory synthesis techniques PNPs subject batch-to-batch variability. Increasing the installation size from scale industrial presents many difficulties. This review explores advances developing productivity systems synthesizing NPs an easy, fast, controlled manner challenges development, optimization, enhancement, feasibility, fabrication. There advantages use biocompatible biodegradable properties. Upscaling occur lot metal NPs, which can be reference PNPs; there similar PNPs.

Язык: Английский

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Nanomaterials in tumor immunotherapy: new strategies and challenges

Molecular Cancer, Год журнала: 2023, Номер 22(1)

Опубликована: Июнь 13, 2023

Abstract Tumor immunotherapy exerts its anti-tumor effects by stimulating and enhancing immune responses of the body. It has become another important modality therapy with significant clinical efficacy advantages compared to chemotherapy, radiotherapy targeted therapy. Although various kinds tumor immunotherapeutic drugs have emerged, challenges faced in delivery these drugs, such as poor permeability low cell uptake rate, had prevented their widespread application. Recently, nanomaterials emerged a means for treatment different diseases due targeting properties, biocompatibility functionalities. Moreover, possess characteristics that overcome defects traditional immunotherapy, large drug loading capacity, precise easy modification, thus leading wide application immunotherapy. There are two main classes novel nanoparticles mentioned this review: organic (polymeric nanomaterials, liposomes lipid nanoparticles) inorganic (non-metallic metallic nanomaterials). Besides, fabrication method nanoparticles, Nanoemulsions, was also introduced. In summary, review article mainly discussed research progress based on past few years offers theoretical basis exploring strategies future.

Язык: Английский

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Advances of medical nanorobots for future cancer treatments

Journal of Hematology & Oncology, Год журнала: 2023, Номер 16(1)

Опубликована: Июль 14, 2023

Early detection and diagnosis of many cancers is very challenging. Late stage a cancer always leads to high mortality rates. It imperative develop novel more sensitive effective therapeutic methods for treatments. The development new treatments has become crucial aspect medical advancements. Nanobots, as one the most promising applications nanomedicines, are at forefront multidisciplinary research. With progress nanotechnology, nanobots enable assembly deployment functional molecular/nanosized machines increasingly being utilized in treatment. In recent years, various practical have transitioned from theory practice, vitro experiments vivo applications. this paper, we review analyze advancements treatments, with particular emphasis on their key fundamental features drug delivery, tumor sensing diagnosis, targeted therapy, minimally invasive surgery, other comprehensive At same time, discuss challenges potential research opportunities revolutionizing future, expected sophisticated capable performing multiple functions tasks, ultimately becoming true nanosubmarines bloodstream.

Язык: Английский

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