Royal Society of Chemistry eBooks,
Год журнала:
2025,
Номер
unknown, С. 1 - 11
Опубликована: Янв. 31, 2025
Globally,
millions
of
deaths
are
reported
annually
due
to
cancer,
bacterial,
fungal,
viral
and
parasitic
diseases,
diabetes
inflammatory
conditions.
Metal
complexes
have
been
extensively
developed
tested
for
their
anticancer,
antibacterial,
antifungal,
antiviral,
antiparasitic,
antidiabetic
anti-inflammatory
properties.
It
is
encouraging
learn
that
many
metal
with
interesting
therapeutic
properties
developed.
Notably,
several
being
used
in
the
treatment
various
diseases.
This
chapter
provides
an
overview
conditions
throughout
world.
In
addition,
advent
these
described.
Moreover,
trends
published
literature
design
development
gold
discussed.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Авг. 12, 2024
Cancer
remains
a
significant
risk
to
human
health.
Nanomedicine
is
new
multidisciplinary
field
that
garnering
lot
of
interest
and
investigation.
shows
great
potential
for
cancer
diagnosis
treatment.
Specifically
engineered
nanoparticles
can
be
employed
as
contrast
agents
in
diagnostics
enable
high
sensitivity
high-resolution
tumor
detection
by
imaging
examinations.
Novel
approaches
labeling
are
also
made
possible
the
use
nanoprobes
nanobiosensors.
The
achievement
targeted
medication
delivery
therapy
accomplished
through
rational
design
manufacture
nanodrug
carriers.
Nanoparticles
have
capability
effectively
transport
medications
or
gene
fragments
tissues
via
passive
active
targeting
processes,
thus
enhancing
treatment
outcomes
while
minimizing
harm
healthy
tissues.
Simultaneously,
context
radiation
sensitization
photothermal
enhance
therapeutic
efficacy
malignant
tumors.
This
review
presents
literature
overview
summary
how
nanotechnology
used
According
oncological
diseases
originating
from
different
systems
body
combining
pathophysiological
features
cancers
at
sites,
we
most
recent
developments
applications.
Finally,
briefly
discuss
prospects
challenges
cancer.
ACS Nano,
Год журнала:
2023,
Номер
17(20), С. 19581 - 19599
Опубликована: Окт. 11, 2023
Transition
metal
elements,
such
as
copper,
play
diverse
and
pivotal
roles
in
oncology.
They
act
constituents
of
metalloenzymes
involved
cellular
metabolism,
function
signaling
molecules
to
regulate
the
proliferation
metastasis
tumors,
are
integral
components
metal-based
anticancer
drugs.
Notably,
recent
research
reveals
that
excessive
copper
can
also
modulate
occurrence
programmed
cell
death
(PCD),
known
cuprotosis,
cancer
cells.
This
modulation
occurs
through
disruption
tumor
metabolism
induction
proteotoxic
stress.
discovery
uncovers
a
mode
interaction
between
transition
metals
proteins,
emphasizing
intricate
link
homeostasis
metabolism.
Moreover,
they
provide
innovative
therapeutic
strategies
for
precise
diagnosis
treatment
malignant
tumors.
At
crossroads
chemistry
oncology,
we
undertake
comprehensive
review
elucidating
molecular
mechanisms
underpinning
cuproptosis.
Additionally,
summarize
current
nanotherapeutic
approaches
target
cuproptosis
an
overview
available
laboratory
clinical
methods
monitoring
this
process.
In
context
emerging
concepts,
challenges,
opportunities,
emphasize
significant
potential
nanotechnology
advancement
field.
Chemical Reviews,
Год журнала:
2023,
Номер
123(10), С. 6612 - 6667
Опубликована: Апрель 18, 2023
The
gold
drugs,
sodium
thiomalate
(Myocrisin),
aurothioglucose
(Solganal),
and
the
orally
administered
auranofin
(Ridaura),
are
utilized
in
modern
medicine
for
treatment
of
inflammatory
arthritis
including
rheumatoid
juvenile
arthritis;
however,
new
agents
have
been
slow
to
enter
clinic.
Repurposing
different
disease
indications
such
as
cancer,
parasitic,
microbial
infections
clinic
has
provided
impetus
development
complexes
biomedical
applications
based
on
unique
mechanistic
insights
differentiated
from
auranofin.
Various
chemical
methods
preparation
physiologically
stable
associated
mechanisms
explored
biomedicine
therapeutics
or
probes.
In
this
Review,
we
discuss
chemistry
next
generation
which
encompasses
oxidation
states,
geometry,
ligands,
coordination,
organometallic
compounds
infectious
diseases,
inflammation,
tools
biology
via
gold-protein
interactions.
We
will
focus
within
past
decade.
Review
provides
readers
with
an
accessible
overview
utility,
development,
mechanism
action
gold-based
small
molecules
establish
context
basis
thriving
resurgence
medicine.
ACS Central Science,
Год журнала:
2024,
Номер
10(2), С. 242 - 250
Опубликована: Фев. 7, 2024
The
discovery
of
the
medicinal
properties
platinum
complexes
has
fueled
design
and
synthesis
new
anticancer
metallodrugs
endowed
with
unique
modes
action
(MoA).
Among
various
families
experimental
antiproliferative
agents,
organometallics
have
emerged
as
ideal
platforms
to
control
compounds'
reactivity
stability
in
a
physiological
environment.
This
is
advantageous
efficiently
deliver
novel
prodrug
activation
strategies,
well
acting
only
via
noncovalent
interactions
their
pharmacological
targets.
Noteworthy,
another
justification
for
advance
organometallic
compounds
therapy
stems
from
ability
catalyze
bioorthogonal
reactions
cancer
cells.
When
not
yet
drug
leads,
such
can
be
used
selective
chemical
tools
that
benefit
advantages
catalytic
amplification
either
label
target
interest
(e.g.,
proteins)
or
boost
output
biochemical
signals.
Examples
so-called
"catalysis
cells"
are
considered
this
Outlook
together
other
candidates.
selected
case
studies
discussed
frame
more
general
challenges
field
inorganic
chemistry.
Nucleic Acids Research,
Год журнала:
2025,
Номер
53(1)
Опубликована: Янв. 7, 2025
Abstract
Copper
compounds
with
artificial
metallo-nuclease
(AMN)
activity
are
mechanistically
unique
compared
to
established
metallodrugs.
Here,
we
describe
the
development
of
a
new
dinuclear
copper
AMN,
Cu2-BPL-C6
(BPL-C6
=
bis-1,10-phenanthroline-carbon-6),
prepared
using
click
chemistry
that
demonstrates
site-specific
DNA
recognition
low
micromolar
cleavage
activity.
The
BPL-C6
ligand
was
designed
force
two
redox-active
centres—central
for
enhancing
AMN
activity—to
bind
DNA,
via
phenanthroline
ligands
separated
by
an
aliphatic
linker.
DNA-binding
experiments,
involving
circular
dichroism
spectroscopy,
agarose
gel
electrophoresis
and
fluorescence
quenching,
revealed
preference
binding
adenine-thymine-rich
DNA.
oxidative
mechanism
then
elucidated
in
vitro
molecular
biophysical
assays,
including
in-liquid
atomic
microscopy
analysis,
revealing
potent
mediated
superoxide
hydrogen
peroxide
pathways.
Single-molecule
analysis
peripheral
blood
mononuclear
cells
identified
upregulated
single-strand
lesions
Cu2-BPL-C6-treated
cells.
Using
specific
base
excision
repair
(BER)
enzymes,
showed
Endo
IV
selectively
repairs
these
indicating
complex
generates
apurinic
apyrimidinic
adducts.
Broad
spectrum
anticancer
evaluation
performed
National
Cancer
Institute’s
60
human
cell
line
screen
(NCI-60)
selectivity
certain
melanoma,
breast,
colon
non-small
lung
cancer
lines.
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
147(9), С. 7908 - 7920
Опубликована: Фев. 24, 2025
Although
various
metal-based
compounds
have
exhibited
excellent
immunogenic
cell
death
(ICD)-inducing
properties
both
in
vitro
and
vivo,
the
majority
of
these
been
discovered
serendipitously.
In
this
work,
we
successfully
synthesized
characterized
35
cyclometalated
Au(III)
complexes
containing
dithiocarbamate
ligands,
with
25
being
previously
unreported.
Their
ability
to
induce
phagocytosis
against
immunologically
"cold"
malignant
pleural
mesothelioma
(MPM)
cells
was
strongly
dependent
on
scaffold
overall
lipophilicity
complexes.
We
elucidated
role
mechanisms
observed
ICD
effects
identified
correlations
between
necrotic
ICD,
vivo.
Complex
2G,
its
high
rates
low
necrosis
rates,
recognized
as
a
bona
fide
inducer,
demonstrating
remarkably
long-lasting
immune
response
vaccinated
mice.
contrast,
complex
1C,
by
failed
elicit
sustained
upon
following
vaccination;
however,
it
triggered
selective
activation
calreticulin
tumors
direct
vivo
administration.
Overall,
study
offers
framework
for
predicting
structurally
similar
complexes,
potential
extension
other
series
metal
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(11), С. 4683 - 4716
Опубликована: Сен. 2, 2024
About
40%
of
approved
drugs
and
nearly
90%
drug
candidates
are
poorly
water-soluble
drugs.
Low
solubility
reduces
the
drugability.
Effectively
improving
bioavailability
is
a
critical
issue
that
needs
to
be
urgently
addressed
in
development
application.
This
review
briefly
introduces
conventional
solubilization
techniques
such
as
solubilizers,
hydrotropes,
cosolvents,
prodrugs,
salt
modification,
micronization,
cyclodextrin
inclusion,
solid
dispersions,
details
crystallization
strategies,
ionic
liquids,
polymer-based,
lipid-based,
inorganic-based
carriers
bioavailability.
Some
most
commonly
used
carrier
materials
for
presented.
Several
using
summarized.
Furthermore,
this
summarizes
mechanism
each
technique,
reviews
latest
research
advances
challenges,
evaluates
potential
clinical
translation.
could
guide
selection
approach,
dosage
form,
administration
route
Moreover,
we
discuss
several
promising
attracting
increasing
attention
worldwide.
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(5), С. 2933 - 2938
Опубликована: Янв. 22, 2024
Most
of
the
known
single-electron
reductants
are
either
metal
based
reagents,
used
in
a
stoichiometric
amount,
or
combination
an
organic
species
and
photocatalyst.
Here
we
report
that
1
