Abstract
Cross-dehydrogenative
coupling
between
E—H
bonds
and
Z—H
bonds,
where
E
Z
are
heteroatoms,
can
be
considered
as
a
green
approach
for
the
construction
of
chemical
bonds.
Since
it
avoids
need
prefunctionalization
starting
materials,
this
type
transformation
shorten
synthetic
routes
increase
total
atom
efficiency.
In
context,
such
reactions
recognized
an
efficient
alternative
to
classical
cross-coupling
reactions.
During
past
decades,
cross-dehydrogenative
strategy
has
been
widely
used
synthesizing
various
target
functional
molecules,
great
achievements
have
made
in
carbon—carbon
bond
formation.
recent
years,
also
employed
construct
heteroatom—heteroatom
bonds;
review
covers
advances
field,
with
focus
on
methods
formation
phosphorus—heteroatom
sulfur—heteroatom
Frontiers in Genetics,
Год журнала:
2022,
Номер
13
Опубликована: Июль 22, 2022
Cutaneous
melanoma
(CM)
is
an
aggressive
form
of
malignancy
with
poor
prognostic
value.
Cuproptosis
a
novel
type
cell
death
regulatory
mechanism
in
tumors.
However,
the
role
cuproptosis-related
long
noncoding
RNAs
(lncRNAs)
CM
remains
elusive.
The
lncRNAs
were
identified
using
Pearson
correlation
algorithm.
Through
univariate
and
multivariate
Cox
regression
analysis,
prognosis
seven
associated
cuproptosis
was
established
new
risk
model
constructed.
ESTIMATE,
CIBERSORT,
single
sample
gene
set
enrichment
analyses
(ssGSEA)
applied
to
evaluate
immune
microenvironment
landscape.
Kaplan–Meier
survival
analysis
revealed
that
overall
(OS)
patients
high-risk
group
remarkably
lower
than
low-risk
group.
result
validated
cohort
training
indicated
could
produce
accurate
prediction
CM.
nomogram
demonstrated
score
based
on
independent
indicator
feature
distinguished
it
from
other
clinical
features.
landscape
showed
better
immunity
immunophenoscore
(IPS)
checkpoints
results
conveyed
benefit
potential
for
immunotherapy
application
groups.
variation
(GSVA)
adopted
reveal
mediated
by
immune-related
signaling
pathways
development
Altogether,
construction
can
accurately
predict
indicate
CM,
providing
perspective
future
treatment
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(4), С. 2190 - 2206
Опубликована: Фев. 1, 2023
A
copper-promoted
aerobic
oxidative
[3+2]
cycloaddition
reaction
for
the
synthesis
of
various
substituted
pyrazoles
from
N,N-disubstituted
hydrazines
with
alkynoates
in
presence
bases
is
developed.
This
work
involves
a
direct
C(sp3)-H
functionalization
and
formation
new
C-C/C-N
bonds.
In
this
strategy,
inexpensive
easily
available
Cu2O
serves
as
promoter
air
acts
green
oxidant.
The
exhibits
advantages
high
atom
step
economy,
regioselectivity,
easy
operation.
Green Chemistry,
Год журнала:
2023,
Номер
25(11), С. 4528 - 4535
Опубликована: Янв. 1, 2023
A
photocatalytic
phosphorylation
of
heteroatom
nucleophiles
has
been
achieved
via
the
direct
coupling
phosphorus-centered
radical
cations
with
nucleophiles.
Organic Chemistry Frontiers,
Год журнала:
2022,
Номер
9(23), С. 6498 - 6504
Опубликована: Янв. 1, 2022
A
visible-light-photoredox-catalyzed
intermolecular
three-component
aminotrifluoromethylation
of
styrenes
with
phenylhydrazines
and
Togni's
reagents/fluoroalkyl
iodides
was
developed.
Advanced Synthesis & Catalysis,
Год журнала:
2022,
Номер
364(24), С. 4275 - 4280
Опубликована: Дек. 3, 2022
Abstract
A
visible‐light‐driven
hydrophosphorylation
of
azobenzenes
with
diarylphosphine
oxides
was
successfully
developed.
The
reaction
proceeded
smoothly
under
blue
light
irradiation
at
room
temperature
without
any
photocatalyst
required,
providing
a
mild
approach
for
this
transformation
new
strategy.
Of
important
note
is
that
the
visible
light‐driven
trans
‐to‐
cis
photoisomerization
found
to
be
key
process
reaction,
highlighting
underestimated
reactivity
in
visible‐light‐promoted
mechanism.
magnified
image
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(10), С. 6729 - 6739
Опубликована: Май 1, 2024
We
have
developed
a
Tf2O-mediated
approach
for
the
direct
amination
of
either
P(O)–OH
or
P(O)–H
reagents
with
variety
aliphatic
aromatic
amines.
Without
requirement
precious
metals
and
toxic
reagents,
this
protocol
provides
an
alternative
route
to
various
phosphinamides
phosphoramides.
The
reaction
proceeds
under
simple
mild
conditions
can
be
effectively
scaled
up
similar
efficiency.
The Journal of Organic Chemistry,
Год журнала:
2022,
Номер
87(15), С. 10467 - 10475
Опубликована: Июль 12, 2022
A
facile
access
to
benzo[d]thiazole-2(3H)-thiones
and
benzo[d]thiazol-2(3H)-ones
has
been
developed
through
a
temperature-controlled
intermolecular
[3
+
2]
annulation
of
N,N-disubstituted
arylhydrazines
with
CS2
in
the
presence
DMSO.
This
protocol
can
obviate
prefunctionalization
starting
materials.
direct
C–S/C–N
bond
formation
reaction
was
performed
absence
any
external
catalysts,
transition
metals,
bases,
ligands,
oxidants
high
step
economy.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(22), С. 16809 - 16827
Опубликована: Ноя. 1, 2024
A
photocatalytic
three-component
cascade
reaction
of
readily
available
enaminones,
hydrazines,
and
CBr4
for
the
synthesis
bromo-substituted
pyrazoles
in
one
pot
has
been
demonstrated.
This
strategy
involves
intermolecular
C-N/C-Br
bond
formation
represents
an
efficient
approach
to
construction
4-bromo-substituted
with
high
regioselectivity,
broad
substrate
scope,
good
functional
group
tolerance,
convenient
operation,
mild
conditions.
Mechanistic
investigations
show
that
this
proceeds
via
cyclization
enaminones
followed
by
a
regioselective
bromination
using
as
"Br"
source.
