New Journal of Chemistry, Год журнала: 2023, Номер 48(5), С. 2183 - 2187
Опубликована: Дек. 26, 2023
An electrochemical approach for synthesizing various trifluoromethylated pyrrolidines was developed by utilizing Langlois’ reagent as the CF 3 source, and different unactivated alkenes can be converted to corresponding heterocycles in 43–80% yields.
Язык: Английский
Chemical Reviews, Год журнала: 2024, Номер unknown
Опубликована: Сен. 13, 2024
Hypervalent iodine(III) compounds have found wide application in modern organic chemistry as environmentally friendly reagents and catalysts. iodine are commonly used synthetically important halogenations, oxidations, aminations, heterocyclizations, various oxidative functionalizations of substrates. Iodonium salts arylating reagents, while iodonium ylides imides excellent carbene nitrene precursors. Various derivatives benziodoxoles, such azidobenziodoxoles, trifluoromethylbenziodoxoles, alkynylbenziodoxoles, alkenylbenziodoxoles group transfer the presence transition metal catalysts, under metal-free conditions, or using photocatalysts photoirradiation conditions. Development hypervalent catalytic systems discovery highly enantioselective reactions chiral represent a particularly recent achievement field chemistry. Chemical transformations promoted by many cases unique cannot be performed any other common, non-iodine-based reagent. This review covers literature published mainly last 7-8 years, between 2016 2024.
Язык: Английский
Процитировано
34
RSC Advances, Год журнала: 2025, Номер 15(19), С. 15302 - 15309
Опубликована: Янв. 1, 2025
Introducing CF 3 groups boosts drug properties by enhancing metabolic stability and bioavailability. This study reports an electrochemical oxidative difunctionalization of flexible alkenes to form -substituted lactones cyclic ethers.
Язык: Английский
Процитировано
0
Advanced Synthesis & Catalysis, Год журнала: 2023, Номер 365(21), С. 3629 - 3636
Опубликована: Сен. 21, 2023
Abstract A visible‐light‐catalyzed formal [3+2] annulation‐aromatization reaction for the synthesis of various substituted imidazo[2,1‐ a ]isoquinolines from amidines with stabilized isoquinolinium N ‐ylides in presence bases is developed. The procedure reported here involves direct C−H activation and formation C−C/C−N bonds one‐pot. mechanism probed by radical‐trapping experiment, fluorescence quenching, light on/off experiments. late‐stage modification experiments provide potential applications field organic medicinal chemistry chemists.
Язык: Английский
Процитировано
7
The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(7), С. 4579 - 4594
Опубликована: Март 20, 2024
A palladium-catalyzed intermolecular [2 + 2 2] oxidative coupling–annulation of terminal alkenes and alkynes using copper(II) as the oxidant has been developed through direct C–C bond formation. These reactions provide effective access to multiaryl-substituted benzenes with high regioselectivity in absence any ligands. The features this protocol are broad substrate scope, atom step economy. aggregation-induced emission properties selected products were further investigated. synthesized may be worth exploring for applications fields advanced functional materials or drugs.
Язык: Английский
Процитировано
2
Organic Letters, Год журнала: 2024, Номер 26(51), С. 11123 - 11128
Опубликована: Дек. 13, 2024
We herein introduce an electrochemical route for the N–N bond cleavage of hydrazines. This mild and green methodology utilized readily available mono- 1,1-disubstituted hydrazines or their HCl salts as starting materials to access a broad scope primary secondary amines in high yields. The mechanistic investigation suggests that amine product is formed by consecutive SET reduction, utilization hydrazine salt important providing sufficient conductivity acidity facilitate this reaction.
Язык: Английский
Процитировано
2
Organic Chemistry Frontiers, Год журнала: 2023, Номер 11(4), С. 1132 - 1139
Опубликована: Дек. 20, 2023
A sequential multi-component reaction of aldehydes and aryl hydrazines for the synthesis N' , -diaryl acylhydrazines with high regioselectivity has been achieved via an aerobic copper-catalyzed process.
Язык: Английский
Процитировано
4
The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(4), С. 2656 - 2664
Опубликована: Фев. 7, 2024
We have developed a metal-free photocatalytic selective hydroxylation of benzylic methylenes to secondary alcohols. This approach utilizes low-cost eosin Y as photocatalyst, O2 green oxidant, and inexpensive triethylamine inhibitor for overoxidation. The mild reaction conditions enable the production alcohols with 56–95% yields, making it promising environmental-friendly method synthesis from methylenes.
Язык: Английский
Процитировано
1
The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(22), С. 16809 - 16827
Опубликована: Ноя. 1, 2024
A photocatalytic three-component cascade reaction of readily available enaminones, hydrazines, and CBr4 for the synthesis bromo-substituted pyrazoles in one pot has been demonstrated. This strategy involves intermolecular C-N/C-Br bond formation represents an efficient approach to construction 4-bromo-substituted with high regioselectivity, broad substrate scope, good functional group tolerance, convenient operation, mild conditions. Mechanistic investigations show that this proceeds via cyclization enaminones followed by a regioselective bromination using as "Br" source.
Язык: Английский
Процитировано
1
Synthetic Communications, Год журнала: 2024, Номер unknown, С. 1 - 23
Опубликована: Дек. 3, 2024
Phenyl hydrazine has attracted attention in photoredox catalytic synthetic strategies for the formation of carbon-carbon (C-C) bond and Carbon-Heteroatom (C-N, C = N, C-P, C-S, S-N) bonds, because low cost ease availability make it a promising alternative method typical transition metal complex-based photocatalyzed synthesis. In this review, we have focused on recent radical coupling reactions phenyl via photochemical to form carbon–carbon carbon–heteroatom (N, P, S) bonds along with mechanism involved their reaction.
Язык: Английский
Процитировано
1
ChemistrySelect, Год журнала: 2024, Номер 10(1)
Опубликована: Дек. 30, 2024
Abstract Phenylhydrazines, comprised of a phenyl group attached with hydrazine unit, contribute potentially to organic synthetic transformations. Because the myriad applications, last decade has witnessed considerable upsurge interest perform various reactions catalyzed/mediated/promoted by phenylhydrazines. Some these have shown high regioselectivity in short reaction time under mild conditions. The emergence innumerable transformations utilizing phenylhydrazine unleashed numerous openings for development diverse heterocyclic scaffolds. Given importance this valuable chemical entity, review highlights methodologies Moreover, present article will considerably synthesis as well pharmaceutical chemistry. Academically, be interesting and informative researchers attempting develop new routes structures.
Язык: Английский
Процитировано
0