EDA Complex-Enabled Annulation to Access CF2-Containing Tetralones and Quinazolinones Using Persulfates as Electron Donors
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(15), С. 10614 - 10623
Опубликована: Июль 25, 2024
A
photocatalyst-free
and
EDA
complex-enabled
radical
cascade
cyclization
reaction
of
inactive
alkenes
with
bromodifluoroacetamides
was
reported
for
the
divergent
synthesis
fluorine-containing
tetralones
quinazolinones.
In
this
transformation,
persulfates
as
electron
donors
difluoro
bromamide
acceptors
generate
complex.
This
is
a
promising
photochemical
method
advantages
such
mild
conditions,
simple
operation,
being
metal-free,
excellent
functional
group
tolerance.
Язык: Английский
General radical difluoromethylation using difluoroacetic anhydride via photoredox catalysis
Science China Chemistry,
Год журнала:
2024,
Номер
67(8), С. 2637 - 2646
Опубликована: Июнь 26, 2024
Язык: Английский
Access to quaternary-carbon-containing β-alkyl amides via persulfate-promoted domino alkylation/smiles rearrangement of alkenes
RSC Advances,
Год журнала:
2025,
Номер
15(20), С. 16183 - 16186
Опубликована: Янв. 1, 2025
An
efficient
radical
alkylative
annulation/arylation
of
N
-(arylsulfonyl)acrylamide
with
4-alkyl-1,4-dihydropyridines
(DHP)
was
developed
for
synthesizing
all-carbon
quaternary-centered
β-alkyl
amides.
Язык: Английский
Harnessing (Phenylsulfonyl)difluoromethyl Sulfonium Salt: A Radical Approach to Photoredox-Catalyzed Functionalization of Unsaturated Compounds with the PhSO2CF2 Group
JACS Au,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 22, 2025
Язык: Английский
Unusual Regio‐ and Chemoselectivity in Oxidation of Pyrroles and Indoles Enabled by a Thianthrenium Salt Intermediate
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 3, 2024
A
dearomative
oxidation
of
pyrroles
to
Δ
Язык: Английский
Therapeutic drug monitoring in India: A strength, weakness, opportunity and threats analysis
British Journal of Clinical Pharmacology,
Год журнала:
2023,
Номер
89(11), С. 3247 - 3261
Опубликована: Июнь 1, 2023
Over
the
last
three
to
four
decades,
Therapeutic
Drug
Monitoring
(TDM)
has
shaped
itself
as
therapeutic
drug
management,
an
integral
component
of
precision
medicine.
The
practice
TDM
is
not
extensive
in
India,
despite
being
one
fastest-growing
economies
world.
It
currently
limited
a
few
academic
medical
centres
and
teaching
hospitals.
Apart
from
immunosuppressive
drugs,
several
other
areas,
such
anticancer,
antifungal,
antibiotic
antitubercular,
have
demonstrated
great
potential
improve
patient
outcomes
Indian
settings.
Factors
higher
prevalence
nutritional
deficiencies,
tropical
diseases,
widespread
use
alternative
medicines,
unalike
pharmacogenomics
sparse
population-specific
data
available
on
ranges
drugs
make
population
this
subcontinent
unique
regarding
relevance
TDM.
Despite
impact
clinical
science
its
application,
failed
receive
attention
it
deserves
India.
This
review
intends
bring
out
strength,
weakness,
opportunity
threats
(SWOT)
analysis
for
India
so
that
appropriate
steps
fostering
growth
could
be
envisioned.
need
hour
creation
cooperative
group
including
all
stakeholders,
professionals,
clinicians
government
devising
National
Action
Plan
strengthen
Nodal
should
established,
pilot
programmes
rolled
identify
thrust
areas
country,
capacity
building
creating
awareness
integrate
into
mainstream
Язык: Английский
Unusual Regio‐ and Chemoselectivity in Oxidation of Pyrroles and Indoles Enabled by a Thianthrenium Salt Intermediate
Angewandte Chemie,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 3, 2024
Abstract
A
dearomative
oxidation
of
pyrroles
to
Δ
3
‐pyrrol‐2‐ones
is
described,
which
employs
a
sulfoxide
as
oxidant,
in
conjunction
with
carboxylic
acid
anhydride
and
Brønsted
additive.
3‐substituted
undergo
regioselective
give
the
product
isomer
oxygen
has
been
introduced
at
more
hindered
position.
Regioselectivity
rationalized
by
proposed
mechanism
that
proceeds
initial
thianthrenium
introduction
less‐hindered
pyrrole
α‐position,
followed
distal
attack
an
nucleophile
subsequent
elimination
thianthrene.
The
same
reaction
conditions
are
also
able
effect
chemoselective
indoles
indolin‐3‐ones
additionally
2‐hydroxyindolin‐3‐ones.
Here
again,
regio‐
chemoselectivities
through
intermediacy
salt.
Язык: Английский
Visible light–driven organic synthesis under iridium (IrIII)-complex photocatalysis
Elsevier eBooks,
Год журнала:
2024,
Номер
unknown, С. 221 - 300
Опубликована: Авг. 16, 2024
Язык: Английский
1.6 Synthesis of Difluoromethylated Compounds
Опубликована: Янв. 1, 2024
Abstract
The
difluoromethyl
group
(CF2H)
can
function
as
a
lipophilic
hydrogen-bond
donor,
and
is
regarded
bioisostere
of
functional
groups
such
hydroxy
(-OH),
thiol
(-SH),
amino
(-NH2).
unique
physicochemical
properties
this
make
difluoromethylation
hot
topic
in
the
field
synthetic
organic
chemistry,
recent
decades,
various
methods
have
been
developed
for
constructing
C(sp3)—CF2H,
C(sp2)—CF2H,
C(sp)
—CF2H,
X—CF2H
(X
=
N,
O,
S,
Se,
B,
P,
etc.)
bonds.
This
review
summarizes
currently
available
reagents
performing
reactions,
well
other
approaches
installing
unit.
Язык: Английский