1.6 Synthesis of Difluoromethylated Compounds DOI
Simin Wu, Hayeon Song, Mingyou Hu

et al.

Published: Jan. 1, 2024

Abstract The difluoromethyl group (CF2H) can function as a lipophilic hydrogen-bond donor, and is regarded bioisostere of functional groups such hydroxy (-OH), thiol (-SH), amino (-NH2). unique physicochemical properties this make difluoromethylation hot topic in the field synthetic organic chemistry, recent decades, various methods have been developed for constructing C(sp3)—CF2H, C(sp2)—CF2H, C(sp) —CF2H, X—CF2H (X = N, O, S, Se, B, P, etc.) bonds. This review summarizes currently available reagents performing reactions, well other approaches installing unit.

Language: Английский

EDA Complex-Enabled Annulation to Access CF2-Containing Tetralones and Quinazolinones Using Persulfates as Electron Donors DOI
Shupeng Zhang, Dawei Guo,

Mei-Ling Yang

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(15), P. 10614 - 10623

Published: July 25, 2024

A photocatalyst-free and EDA complex-enabled radical cascade cyclization reaction of inactive alkenes with bromodifluoroacetamides was reported for the divergent synthesis fluorine-containing tetralones quinazolinones. In this transformation, persulfates as electron donors difluoro bromamide acceptors generate complex. This is a promising photochemical method advantages such mild conditions, simple operation, being metal-free, excellent functional group tolerance.

Language: Английский

Citations

6
Access to quaternary-carbon-containing β-alkyl amides via persulfate-promoted domino alkylation/smiles rearrangement of alkenes DOI Creative Commons
Xiaohu Yang, Xiaoqing Wan, Wenchao Yang

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(20), P. 16183 - 16186

Published: Jan. 1, 2025

An efficient radical alkylative annulation/arylation of N -(arylsulfonyl)acrylamide with 4-alkyl-1,4-dihydropyridines (DHP) was developed for synthesizing all-carbon quaternary-centered β-alkyl amides.

Language: Английский

Citations

0
Unusual Regio‐ and Chemoselectivity in Oxidation of Pyrroles and Indoles Enabled by a Thianthrenium Salt Intermediate DOI Creative Commons
Jodie L. Hann, Catherine L. Lyall, Gabriele Kociok‐Köhn

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: June 3, 2024

A dearomative oxidation of pyrroles to Δ

Language: Английский

Citations

2
General radical difluoromethylation using difluoroacetic anhydride via photoredox catalysis DOI
Meng He,

Yankai Yang,

Heng Zhang

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: 67(8), P. 2637 - 2646

Published: June 26, 2024

Language: Английский

Citations

2
Therapeutic drug monitoring in India: A strength, weakness, opportunity and threats analysis DOI
Smita Pattanaik, Vikram Gota, Santanu Kumar Tripathi

et al.

British Journal of Clinical Pharmacology, Journal Year: 2023, Volume and Issue: 89(11), P. 3247 - 3261

Published: June 1, 2023

Over the last three to four decades, Therapeutic Drug Monitoring (TDM) has shaped itself as therapeutic drug management, an integral component of precision medicine. The practice TDM is not extensive in India, despite being one fastest-growing economies world. It currently limited a few academic medical centres and teaching hospitals. Apart from immunosuppressive drugs, several other areas, such anticancer, antifungal, antibiotic antitubercular, have demonstrated great potential improve patient outcomes Indian settings. Factors higher prevalence nutritional deficiencies, tropical diseases, widespread use alternative medicines, unalike pharmacogenomics sparse population-specific data available on ranges drugs make population this subcontinent unique regarding relevance TDM. Despite impact clinical science its application, failed receive attention it deserves India. This review intends bring out strength, weakness, opportunity threats (SWOT) analysis for India so that appropriate steps fostering growth could be envisioned. need hour creation cooperative group including all stakeholders, professionals, clinicians government devising National Action Plan strengthen Nodal should established, pilot programmes rolled identify thrust areas country, capacity building creating awareness integrate into mainstream

Language: Английский

Citations

2
Unusual Regio‐ and Chemoselectivity in Oxidation of Pyrroles and Indoles Enabled by a Thianthrenium Salt Intermediate DOI Creative Commons
Jodie L. Hann, Catherine L. Lyall, Gabriele Kociok‐Köhn

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: June 3, 2024

Abstract A dearomative oxidation of pyrroles to Δ 3 ‐pyrrol‐2‐ones is described, which employs a sulfoxide as oxidant, in conjunction with carboxylic acid anhydride and Brønsted additive. 3‐substituted undergo regioselective give the product isomer oxygen has been introduced at more hindered position. Regioselectivity rationalized by proposed mechanism that proceeds initial thianthrenium introduction less‐hindered pyrrole α‐position, followed distal attack an nucleophile subsequent elimination thianthrene. The same reaction conditions are also able effect chemoselective indoles indolin‐3‐ones additionally 2‐hydroxyindolin‐3‐ones. Here again, regio‐ chemoselectivities through intermediacy salt.

Language: Английский

Citations

0
Visible light–driven organic synthesis under iridium (IrIII)-complex photocatalysis DOI
Goutam Brahmachari

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 221 - 300

Published: Aug. 16, 2024

Language: Английский

Citations

0
1.6 Synthesis of Difluoromethylated Compounds DOI
Simin Wu, Hayeon Song, Mingyou Hu

et al.

Published: Jan. 1, 2024

Abstract The difluoromethyl group (CF2H) can function as a lipophilic hydrogen-bond donor, and is regarded bioisostere of functional groups such hydroxy (-OH), thiol (-SH), amino (-NH2). unique physicochemical properties this make difluoromethylation hot topic in the field synthetic organic chemistry, recent decades, various methods have been developed for constructing C(sp3)—CF2H, C(sp2)—CF2H, C(sp) —CF2H, X—CF2H (X = N, O, S, Se, B, P, etc.) bonds. This review summarizes currently available reagents performing reactions, well other approaches installing unit.

Language: Английский

Citations

0