Advances in medical technologies and clinical practice book series,
Год журнала:
2024,
Номер
unknown, С. 219 - 236
Опубликована: Ноя. 29, 2024
The
old
procedures
of
the
conventional
histology
process
continue
to
limit
pathologists.
Bone
structure
is
complex,
which
makes
diagnosis
difficult.
To
improve
diagnostic
capacities
using
CAD
tools,
digital
histopathology
must
be
used.
development
automated
techniques
needs
investigation
based
on
various
facets
bone
structure.
assess
tumor
density
methods
have
been
created
still
image
classification
remains
a
considerable
address
this
issue,
Convolutional
algorithm
used
for
identifying
different
types
cancer
images.
differentiate
between
healthy
&
damaged
sections,
our
approach
combines
important
classifiers
and
applies
Karhunen-Loeve
extraction
method
certain
picture
attributes.
results
found
are
subsequently
fed
with
help
ML
enhance
accuracy
i.e.
97.3%
detection
prediction.
proposed
method,
algorithms
histopathological
analysis,
provides
promising
increase
effectiveness
identification
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(6), С. 3133 - 3133
Опубликована: Март 8, 2024
The
increasing
demand
for
innovative
approaches
in
wound
healing
and
skin
regeneration
has
prompted
extensive
research
into
advanced
biomaterials.
This
review
focuses
on
showcasing
the
unique
properties
of
sustainable
silk-based
particulate
systems
promoting
controlled
release
pharmaceuticals
bioactive
agents
context
regeneration.
Silk
fibroin
sericin
are
derived
from
well-established
silkworm
production
constitute
a
biocompatible
biodegradable
protein
platform
development
drug
delivery
systems.
therapeutic
compounds
not
only
ensures
optimal
bioavailability
but
also
addresses
challenges
associated
with
conventional
methods.
multifaceted
benefits
silk
proteins,
including
their
inherent
biocompatibility,
versatility,
sustainability,
explored
this
review.
Furthermore,
intricate
mechanisms
by
which
takes
place
carriers
discussed.
Materials Today Bio,
Год журнала:
2023,
Номер
23, С. 100834 - 100834
Опубликована: Окт. 20, 2023
Achieving
precision
treatment
in
bone
tissue
engineering
(BTE)
remains
a
challenge.
Photothermal
therapy
(PTT),
as
form
of
therapy,
has
been
extensively
investigated
for
its
safety
and
efficacy.
It
demonstrated
significant
potential
the
orthopedic
diseases
such
tumors,
postoperative
infections
osteoarthritis.
However,
high
temperatures
associated
with
PTT
can
lead
to
certain
limitations
drawbacks.
In
recent
years,
researchers
have
explored
use
biomaterials
mild
photothermal
(MPT),
which
offers
promising
approach
addressing
these
limitations.
This
review
provides
comprehensive
overview
mechanisms
underlying
MPT
presents
compilation
agents
their
utilization
strategies
repair.
Additionally,
paper
discusses
future
prospects
MPT-assisted
regeneration,
aiming
provide
insights
recommendations
optimizing
material
design
this
field.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 10, 2024
Abstract
The
pioneering
work
on
liposomes
in
the
1960s
and
subsequent
research
controlled
drug
release
systems
significantly
advances
development
of
nanocarriers
(NCs)
for
delivery.
This
field
is
evolved
to
include
a
diverse
array
such
as
liposomes,
polymeric
nanoparticles,
dendrimers,
more,
each
tailored
specific
therapeutic
applications.
Despite
significant
achievements,
clinical
translation
limited,
primarily
due
low
efficiency
delivery
an
incomplete
understanding
nanocarrier
interactions
with
biological
systems.
Addressing
these
challenges
requires
interdisciplinary
collaboration
deep
nano‐bio
interface.
To
enhance
design,
scientists
employ
both
physics‐based
data‐driven
models.
Physics‐based
models
provide
detailed
insights
into
chemical
reactions
at
atomic
molecular
scales,
while
leverage
machine
learning
analyze
large
datasets
uncover
hidden
mechanisms.
integration
presents
harmonizing
different
modeling
approaches
ensuring
model
validation
generalization
across
However,
this
crucial
developing
effective
targeted
By
integrating
enhanced
data
infrastructure,
explainable
AI,
computational
advances,
potentials,
researchers
can
develop
innovative
nanomedicine
solutions,
ultimately
improving
outcomes.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
unknown
Опубликована: Март 28, 2024
Biomaterial-mediated
bone
tissue
engineering
(BTE)
offers
an
alternative,
interesting
approach
for
the
restoration
of
damaged
tissues
in
postsurgery
osteosarcoma
treatment.
This
study
focused
on
synthesizing
innovative
composite
inks,
integrating
self-assembled
silk
fibroin
(SF),
tannic
acids
(TA),
and
electrospun
bioactive
glass
nanofibers
70SiO2-25CaO-5P2O5
(BGNF).
By
synergistically
combining
unique
characteristics
these
three
components
through
self-assembly
microextrusion-based
three-dimensional
(3D)
printing,
our
goal
was
to
produce
durable
versatile
aerogel-based
3D
scaffolds.
These
scaffolds
were
designed
exhibit
hierarchical
porosity
along
with
antibacterial,
antiosteosarcoma,
regeneration
properties.
Taking
inspiration
from
mussel
foot
protein
attachment
chemistry
involving
coordination
dihydroxyphenylalanine
(DOPA)
amino
ferric
ions
(Fe3+),
we
synthesized
a
tris-complex
catecholate-iron
gel.
gel
formation
occurred
oxidized
SF
(SFO)
TA
polydopamine-modified
BGNF
(BGNF-PDA).
The
dynamic
nature
ligand–metal
bonds
within
SFO
matrix
provided
excellent
shear-thinning
properties,
allowing
SFO-TA-BGNF
complex
be
extruded
nozzle,
facilitating
printing
into
outstanding
shape
fidelity.
Moreover,
developed
aerogels
exhibited
multifaceted
features,
including
NIR-triggered
photothermal
antibacterial
vitro
antiosteosarcoma
In
studies
showcased
their
biocompatibility
osteogenic
features
as
seeded
cells
successfully
differentiated
osteoblasts,
promoting
21
days.
Through
comprehensive
characterizations
biological
validations,
scaffold
demonstrated
promise
exceptional
platform
concurrent
cancer
therapy,
setting
stage
potential
clinical
application.
ACS Materials Au,
Год журнала:
2023,
Номер
3(6), С. 711 - 726
Опубликована: Сен. 8, 2023
Aiming
to
address
the
bone
regeneration
and
cancer
therapy
functionalities
in
one
single
material,
this
study,
we
developed
a
dual-functional
theragenerative
three-dimensional
(3D)
aerogel-based
composite
scaffold
from
hybridization
of
photo-cross-linked
silk
fibroin
(SF)
biopolymer
with
MXene
(Ti3C2)
two-dimensional
(2D)
nanosheets.
To
fabricate
scaffold,
first
develop
dual-cross-linked
SF-based
aerogel
through
3D
printing
photo-cross-linking
self-assembly-driven
methacrylate-modified
SF
(SF-MA)
gel
controlled
pore
size,
macroscopic
geometry,
mechanical
stability.
In
next
step,
endow
remotely
photothermal
antiosteosarcoma
ablation
function
fabricated
2D
nanosheets
strong
near-infrared
(NIR)
photon
absorption
properties
were
integrated
into
3D-printed
scaffolds.
While
MXene-modified
scaffolds
can
mediate
vitro
growth
proliferation
preosteoblastic
cell
lines,
they
also
effect
upon
remote
irradiation
NIR
laser
but
significantly
stimulate
mineral
deposition
on
surface.
Additionally,
besides
local
release
anticancer
model
drug,
generated
heat
(45-53
°C)
mediated
cells.
The
composites
chosen
therapeutic
techniques
are
thought
render
significant
breakthrough
biomaterials'
future
clinical
applications.
Cellulose,
Год журнала:
2023,
Номер
31(1), С. 515 - 534
Опубликована: Дек. 12, 2023
Abstract
Nanostructured
scaffolds
based
on
cellulose
with
advanced
performances
and
personalized
morphologies
for
bone
tissue
engineering
are
under
technological
development.
3D-printing
supercritical
carbon
dioxide
(scCO
2
)
technologies
innovative
processing
strategies
that,
when
combined,
allow
the
precise
fabrication
of
highly
porous
aerogel
scaffolds.
Novel
sterile
cellulose-in-cellulose
aerogels
decorated
superparamagnetic
iron
oxide
nanoparticles
(SPIONs)
synthesized
in
this
work
by
an
integrated
platform
scCO
.
Methylcellulose
(MC)
bacterial
nanocellulose
(BC)
two
versatile
cellulosic
polysaccharides
remarkable
physicochemical
biological
performances,
whereas
SPIONs
commonly
used
to
functionalize
biomaterials
aimed
at
engineering.
Aerogels
hierarchical
porosity
high
structural
resolution
were
obtained
according
nitrogen
adsorption–desorption
analysis,
confocal,
scanning
transmission
microscopies
(SEM
TEM).
The
magnetic
properties
SPIONs-doped
confirmed
correct
functionalization
nanostructures.
Finally,
NIH/3T3
fibroblast
cell
viability,
hemocompatibility
human
blood
safety
tests
(
ovo
HET-CAM
vivo
Artemia
salina
indicate
biocompatibility
aerogels.
Graphical
abstract
Abstract
3D
printing
is
now
recognized
as
a
significant
tool
for
medical
research
and
clinical
practice,
leading
to
the
emergence
of
technology.
It
essential
improve
properties
3D‐printed
products
meet
demand
use.
The
core
generating
qualified
develop
advanced
materials
processes.
Taking
advantage
nanomaterials
with
tunable
distinct
physical,
chemical,
biological
properties,
integrating
nanotechnology
into
creates
new
opportunities
advancing
field.
Recently,
some
attempts
are
made
through
nanotechnology,
providing
insights
developing
With
high‐resolution
technology,
nano‐structures
can
be
directly
fabricated
applications.
Incorporating
material
system
products.
At
same
time,
used
expand
novel
technologies.
This
review
introduced
strategies
progresses
improving
discussed
challenges
in
translation.
Biomimetics,
Год журнала:
2024,
Номер
9(7), С. 397 - 397
Опубликована: Июнь 30, 2024
Aerogels
are
lightweight
and
highly
porous
materials
that
have
been
found
to
great
potential
in
biomedical
research
because
of
some
their
unique
properties,
such
as
high
surface
area,
tunable
porosity,
biocompatibility.
Researchers
exploring
ways
use
aerogels
create
biomimetic
scaffolds
inspired
by
natural
extracellular
matrices
(ECMs)
for
various
applications.
Aerogel
can
serve
three-dimensional
(3D)
templates
cell
growth
tissue
regeneration,
promoting
wound
healing
repair.
Additionally,
aerogel-based
controlled
drug
delivery
systems,
where
area
porosity
enable
the
efficient
loading
release
therapeutic
agents.
In
this
review,
we
discuss
biopolymer-based
aerogel
engineering,
delivery,
biosensors.
Finally,
also
directions
development
scaffolds.
