Sustainable Silk-Based Particulate Systems for the Controlled Release of Pharmaceuticals and Bioactive Agents in Wound Healing and Skin Regeneration

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3133 - 3133

Published: March 8, 2024

The increasing demand for innovative approaches in wound healing and skin regeneration has prompted extensive research into advanced biomaterials. This review focuses on showcasing the unique properties of sustainable silk-based particulate systems promoting controlled release pharmaceuticals bioactive agents context regeneration. Silk fibroin sericin are derived from well-established silkworm production constitute a biocompatible biodegradable protein platform development drug delivery systems. therapeutic compounds not only ensures optimal bioavailability but also addresses challenges associated with conventional methods. multifaceted benefits silk proteins, including their inherent biocompatibility, versatility, sustainability, explored this review. Furthermore, intricate mechanisms by which takes place carriers discussed.

Language: Английский

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Mild photothermal therapy assist in promoting bone repair: Related mechanism and materials

Materials Today Bio, Journal Year: 2023, Volume and Issue: 23, P. 100834 - 100834

Published: Oct. 20, 2023

Achieving precision treatment in bone tissue engineering (BTE) remains a challenge. Photothermal therapy (PTT), as form of therapy, has been extensively investigated for its safety and efficacy. It demonstrated significant potential the orthopedic diseases such tumors, postoperative infections osteoarthritis. However, high temperatures associated with PTT can lead to certain limitations drawbacks. In recent years, researchers have explored use biomaterials mild photothermal (MPT), which offers promising approach addressing these limitations. This review provides comprehensive overview mechanisms underlying MPT presents compilation agents their utilization strategies repair. Additionally, paper discusses future prospects MPT-assisted regeneration, aiming provide insights recommendations optimizing material design this field.

Language: Английский

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Silk fibroin-derived electrospun materials for biomedical applications: A review

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 254, P. 127641 - 127641

Published: Oct. 31, 2023

Language: Английский

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Toward the Integration of Machine Learning and Molecular Modeling for Designing Drug Delivery Nanocarriers

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Abstract The pioneering work on liposomes in the 1960s and subsequent research controlled drug release systems significantly advances development of nanocarriers (NCs) for delivery. This field is evolved to include a diverse array such as liposomes, polymeric nanoparticles, dendrimers, more, each tailored specific therapeutic applications. Despite significant achievements, clinical translation limited, primarily due low efficiency delivery an incomplete understanding nanocarrier interactions with biological systems. Addressing these challenges requires interdisciplinary collaboration deep nano‐bio interface. To enhance design, scientists employ both physics‐based data‐driven models. Physics‐based models provide detailed insights into chemical reactions at atomic molecular scales, while leverage machine learning analyze large datasets uncover hidden mechanisms. integration presents harmonizing different modeling approaches ensuring model validation generalization across However, this crucial developing effective targeted By integrating enhanced data infrastructure, explainable AI, computational advances, potentials, researchers can develop innovative nanomedicine solutions, ultimately improving outcomes.

Language: Английский

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Designing of a Multifunctional 3D-Printed Biomimetic Theragenerative Aerogel Scaffold via Mussel-Inspired Chemistry: Bioactive Glass Nanofiber-Incorporated Self-Assembled Silk Fibroin with Antibacterial, Antiosteosarcoma, and Osteoinductive Properties

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: March 28, 2024

Biomaterial-mediated bone tissue engineering (BTE) offers an alternative, interesting approach for the restoration of damaged tissues in postsurgery osteosarcoma treatment. This study focused on synthesizing innovative composite inks, integrating self-assembled silk fibroin (SF), tannic acids (TA), and electrospun bioactive glass nanofibers 70SiO2-25CaO-5P2O5 (BGNF). By synergistically combining unique characteristics these three components through self-assembly microextrusion-based three-dimensional (3D) printing, our goal was to produce durable versatile aerogel-based 3D scaffolds. These scaffolds were designed exhibit hierarchical porosity along with antibacterial, antiosteosarcoma, regeneration properties. Taking inspiration from mussel foot protein attachment chemistry involving coordination dihydroxyphenylalanine (DOPA) amino ferric ions (Fe3+), we synthesized a tris-complex catecholate-iron gel. gel formation occurred oxidized SF (SFO) TA polydopamine-modified BGNF (BGNF-PDA). The dynamic nature ligand–metal bonds within SFO matrix provided excellent shear-thinning properties, allowing SFO-TA-BGNF complex be extruded nozzle, facilitating printing into outstanding shape fidelity. Moreover, developed aerogels exhibited multifaceted features, including NIR-triggered photothermal antibacterial vitro antiosteosarcoma In studies showcased their biocompatibility osteogenic features as seeded cells successfully differentiated osteoblasts, promoting 21 days. Through comprehensive characterizations biological validations, scaffold demonstrated promise exceptional platform concurrent cancer therapy, setting stage potential clinical application.

Language: Английский

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MXene-Integrated Silk Fibroin-Based Self-Assembly-Driven 3D-Printed Theragenerative Scaffolds for Remotely Photothermal Anti-Osteosarcoma Ablation and Bone Regeneration

ACS Materials Au, Journal Year: 2023, Volume and Issue: 3(6), P. 711 - 726

Published: Sept. 8, 2023

Aiming to address the bone regeneration and cancer therapy functionalities in one single material, this study, we developed a dual-functional theragenerative three-dimensional (3D) aerogel-based composite scaffold from hybridization of photo-cross-linked silk fibroin (SF) biopolymer with MXene (Ti3C2) two-dimensional (2D) nanosheets. To fabricate scaffold, first develop dual-cross-linked SF-based aerogel through 3D printing photo-cross-linking self-assembly-driven methacrylate-modified SF (SF-MA) gel controlled pore size, macroscopic geometry, mechanical stability. In next step, endow remotely photothermal antiosteosarcoma ablation function fabricated 2D nanosheets strong near-infrared (NIR) photon absorption properties were integrated into 3D-printed scaffolds. While MXene-modified scaffolds can mediate vitro growth proliferation preosteoblastic cell lines, they also effect upon remote irradiation NIR laser but significantly stimulate mineral deposition on surface. Additionally, besides local release anticancer model drug, generated heat (45-53 °C) mediated cells. The composites chosen therapeutic techniques are thought render significant breakthrough biomaterials' future clinical applications.

Language: Английский

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Cellulose-in-cellulose 3D-printed bioaerogels for bone tissue engineering

Cellulose, Journal Year: 2023, Volume and Issue: 31(1), P. 515 - 534

Published: Dec. 12, 2023

Abstract Nanostructured scaffolds based on cellulose with advanced performances and personalized morphologies for bone tissue engineering are under technological development. 3D-printing supercritical carbon dioxide (scCO 2 ) technologies innovative processing strategies that, when combined, allow the precise fabrication of highly porous aerogel scaffolds. Novel sterile cellulose-in-cellulose aerogels decorated superparamagnetic iron oxide nanoparticles (SPIONs) synthesized in this work by an integrated platform scCO . Methylcellulose (MC) bacterial nanocellulose (BC) two versatile cellulosic polysaccharides remarkable physicochemical biological performances, whereas SPIONs commonly used to functionalize biomaterials aimed at engineering. Aerogels hierarchical porosity high structural resolution were obtained according nitrogen adsorption–desorption analysis, confocal, scanning transmission microscopies (SEM TEM). The magnetic properties SPIONs-doped confirmed correct functionalization nanostructures. Finally, NIH/3T3 fibroblast cell viability, hemocompatibility human blood safety tests ( ovo HET-CAM vivo Artemia salina indicate biocompatibility aerogels. Graphical abstract

Language: Английский

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Recent progress on photothermal nanomaterials: Design, mechanism, and applications

Green Energy & Environment, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

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Advanced Nanomaterials in Medical 3D Printing

Small Methods, Journal Year: 2023, Volume and Issue: 8(3)

Published: Nov. 27, 2023

Abstract 3D printing is now recognized as a significant tool for medical research and clinical practice, leading to the emergence of technology. It essential improve properties 3D‐printed products meet demand use. The core generating qualified develop advanced materials processes. Taking advantage nanomaterials with tunable distinct physical, chemical, biological properties, integrating nanotechnology into creates new opportunities advancing field. Recently, some attempts are made through nanotechnology, providing insights developing With high‐resolution technology, nano‐structures can be directly fabricated applications. Incorporating material system products. At same time, used expand novel technologies. This review introduced strategies progresses improving discussed challenges in translation.

Language: Английский

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Biopolymer-Based Biomimetic Aerogel for Biomedical Applications

Biomimetics, Journal Year: 2024, Volume and Issue: 9(7), P. 397 - 397

Published: June 30, 2024

Aerogels are lightweight and highly porous materials that have been found to great potential in biomedical research because of some their unique properties, such as high surface area, tunable porosity, biocompatibility. Researchers exploring ways use aerogels create biomimetic scaffolds inspired by natural extracellular matrices (ECMs) for various applications. Aerogel can serve three-dimensional (3D) templates cell growth tissue regeneration, promoting wound healing repair. Additionally, aerogel-based controlled drug delivery systems, where area porosity enable the efficient loading release therapeutic agents. In this review, we discuss biopolymer-based aerogel engineering, delivery, biosensors. Finally, also directions development scaffolds.

Language: Английский

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