European Polymer Journal, Год журнала: 2023, Номер 186, С. 111865 - 111865
Опубликована: Янв. 30, 2023
Язык: Английский
Heliyon, Год журнала: 2024, Номер 10(4), С. e26009 - e26009
Опубликована: Фев. 1, 2024
Drug-delivery systems (DDSs) are designed to deliver drugs their specific targets minimize toxic effects and improve susceptibility clearance during targeted transport. Peptides have high affinity, low immunogenicity, simple amino acid composition, adjustable molecular size; therefore, most peptides can be coupled via linkers form peptide-drug conjugates (PDCs) act as active pro-drugs. PDCs widely thought promising DDSs, given ability drug bio-compatibility physiological stability. Peptide-based DDSs often used therapeutic substances such anti-cancer nucleic acid-based drugs, which not only slow the degradation rate of in vivo but also ensure concentration at site prolong half-life vivo.This article provides an profile advancements future development functional peptide-based delivery both domestically internationally recent years, expectation achieving incorporating taking full advantage synergistic effects.
Язык: Английский
Процитировано
21
ChemBioChem, Год журнала: 2024, Номер 25(10)
Опубликована: Март 29, 2024
Abstract Peptides have become an indispensable tool in engineering of multifunctional nanostructure platforms for biomedical applications such as targeted drug and gene delivery, imaging biosensing. They can be covalently incorporated into a variety nanoparticles (NPs) including polymers, metallic nanoparticles, others. Using different bioconjugation techniques, peptide‐modified NPs formulated to produce therapeutical diagnostic offering high specificity, lower toxicity, biocompatibility, stimuli responsive behavior. Targeting peptides direct the specific tissues delivery due their specificity towards certain receptors. Furthermore, stimuli‐responsive features, they offer controlled release therapeutics desired sites disease. In addition, peptide‐based biosensors agents provide non‐invasive detection monitoring diseases cancer, infectious diseases, neurological disorders. this review, we covered design formulation recent NP platforms, well utilization vitro vivo targeting, sensing, applications. end, provided future outlook new peptide conjugated nanomaterials
Язык: Английский
Процитировано
16
International Journal of Pharmaceutics, Год журнала: 2024, Номер 665, С. 124687 - 124687
Опубликована: Сен. 10, 2024
Язык: Английский
Процитировано
11
Advanced NanoBiomed Research, Год журнала: 2024, Номер 4(4)
Опубликована: Фев. 6, 2024
Intracellular assemblies play vital roles in maintaining cellular functions through structural recognition‐mediated interactions. The introduction of artificial structures has garnered substantial interest modulating via activation/inhibition interactions with biomacromolecules. However, the uptake these high‐molecular‐weight may limit their performance. Recently, intracellular chemical‐reaction‐induced self‐assembly emerged as a promising strategy for generating situ nanostructures biofunctionalities interacting This approach addresses challenge synthetic reactions occurring complex environments by utilizing diverse chemical that respond to endogenous and exogenous stimuli. review provides an overview latest advancements techniques. It focuses on responsiveness specific conditions, such redox overexpressed enzymes. Additionally, initiation stimuli, including reagents irradiation is explored. Polymerization‐induced hydrophobicity highlighted, leading into micro‐/nanostructures. These processes contribute construction materials morphologies, offering versatile functionalities biological applications.
Язык: Английский
Процитировано
10
Gels, Год журнала: 2022, Номер 8(9), С. 533 - 533
Опубликована: Авг. 25, 2022
Over the last couple of decades, stimuli-responsive supramolecular gels comprising synthetic short peptides as building blocks have been explored for various biological and material applications. Though a wide range stimuli has tested depending on structure peptides, light stimulus attracted extensive attention due to its non-invasive, non-contaminant, remotely controllable nature, precise spatial temporal resolution, wavelength tunability. The integration molecular photo-switch low-molecular-weight may thus provide access self-assembled systems, notably gels, which be used create dynamic, light-responsive "smart" materials with variety structures functions. This review summarizes recent advancement in area light-sensitive peptide gelation. At first, glimpse commonly photo-switches is given, followed by detailed description their incorporation into sequences design mechanism action. Finally, challenges future perspectives developing next-generation photo-responsive are outlined.
Язык: Английский
Процитировано
25
Journal of Advanced Research, Год журнала: 2024, Номер unknown
Опубликована: Апрель 1, 2024
The construction of gels from low molecular weight gelators (LMWG) has been extensively studied in the fields bio-nanotechnology and other fields. However, understanding gaps still prevent prediction LMWG full design those gel systems. Gels with multicomponent become even more complicated because multiple interference effects coexist composite This review emphasizes systems view on (MLMWGs), summarizes recent progress desired networks MLMWGs, including self-sorting co-assembly, as well challenges approaches to hope that opportunities natural products peptides can speed up process close between structures. is focused three key concepts. Firstly, requires a perspective MLMWGs. Secondly, several protocols be applied control co-assembly behaviors system, certain complementary structures, chirality inducing dynamic control. Thirdly, discussion anchored strategies some examples are provided for constructed small subtle designed short peptides.
Язык: Английский
Процитировано
6
European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 279, С. 116928 - 116928
Опубликована: Сен. 30, 2024
Язык: Английский
Процитировано
5
International Journal of Molecular Sciences, Год журнала: 2022, Номер 24(1), С. 456 - 456
Опубликована: Дек. 27, 2022
Metal–ion coordination has been widely exploited to control the supramolecular behavior of a variety building blocks into functional materials. In particular, peptides offer great chemical diversity for metal-binding modes, combined with inherent biocompatibility and biodegradability that make them attractive especially medicine, sensing, environmental remediation. The focus this review is last 5 years’ progress in exciting field conclude an overview future directions research area currently undertaking.
Язык: Английский
Процитировано
18
Vietnam Journal of Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Авг. 27, 2024
Abstract Annually, cancer accounts for a large number of mortalities worldwide, underscoring the imperative early‐stage detection as public health priority. This article not only offers an in‐depth analysis synthesis, fabrication, design, and structural attributes these nanomaterials but also provides critical evaluation their application in various electrochemical biosensing modalities, including amperometry, impedimetric, photoelectrochemical, potentiometric, field‐effect transistor‐based sensors. A primary focus is placed on importance nanomaterials‐based biosensors detecting biomarkers, emphasizing role achieving enhanced sensitivity specificity circulating tumor cells, nucleic acids, proteins, exosomes, which are crucial indicators malignancy. The valuable insights into biomarkers. It details significance relevance early diagnosis types with nanomaterial‐enhanced biosensors’ stability, reusability, conductivity, shedding light practical applicability real‐world scenarios. manuscript concludes by addressing existing challenges outlining prospective avenues future research, need continued innovation exploration this burgeoning field.
Язык: Английский
Процитировано
4
Protein and Peptide Letters, Год журнала: 2023, Номер 30(8), С. 626 - 639
Опубликована: Июль 7, 2023
Bioactive peptides obtained from natural resources are useful due to their ability prevent the risk of dreadful conditions such as hypertension, cancers, obesity and cardiovascular diseases. Proteins food, plants, animals dairy products chemically or enzymatically hydrolyzed fermented in presence microbes produce bioactive peptides. antioxidant, antihypertensive, anti-inflammatory, antiproliferative, antibacterial, anticancer, antimicrobial some them also show multiple bioactivities. Also, offer much potential nutraceuticals functional food components. This paper reviews recent progress (2020-2022) on derived animals, products. Emphasis is given production, purification, use for health promotions medicinal applications.
Язык: Английский
Процитировано
9