Advances in peptide-based drug delivery systems

Heliyon, Journal Year: 2024, Volume and Issue: 10(4), P. e26009 - e26009

Published: Feb. 1, 2024

Drug-delivery systems (DDSs) are designed to deliver drugs their specific targets minimize toxic effects and improve susceptibility clearance during targeted transport. Peptides have high affinity, low immunogenicity, simple amino acid composition, adjustable molecular size; therefore, most peptides can be coupled via linkers form peptide-drug conjugates (PDCs) act as active pro-drugs. PDCs widely thought promising DDSs, given ability drug bio-compatibility physiological stability. Peptide-based DDSs often used therapeutic substances such anti-cancer nucleic acid-based drugs, which not only slow the degradation rate of in vivo but also ensure concentration at site prolong half-life vivo.This article provides an profile advancements future development functional peptide-based delivery both domestically internationally recent years, expectation achieving incorporating taking full advantage synergistic effects.

Language: Английский

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Peptide‐conjugated Nanoparticle Platforms for Targeted Delivery, Imaging, and Biosensing Applications

ChemBioChem, Journal Year: 2024, Volume and Issue: 25(10)

Published: March 29, 2024

Abstract Peptides have become an indispensable tool in engineering of multifunctional nanostructure platforms for biomedical applications such as targeted drug and gene delivery, imaging biosensing. They can be covalently incorporated into a variety nanoparticles (NPs) including polymers, metallic nanoparticles, others. Using different bioconjugation techniques, peptide‐modified NPs formulated to produce therapeutical diagnostic offering high specificity, lower toxicity, biocompatibility, stimuli responsive behavior. Targeting peptides direct the specific tissues delivery due their specificity towards certain receptors. Furthermore, stimuli‐responsive features, they offer controlled release therapeutics desired sites disease. In addition, peptide‐based biosensors agents provide non‐invasive detection monitoring diseases cancer, infectious diseases, neurological disorders. this review, we covered design formulation recent NP platforms, well utilization vitro vivo targeting, sensing, applications. end, provided future outlook new peptide conjugated nanomaterials

Language: Английский

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Breaking barriers in cancer management: The promising role of microsphere conjugates in cancer diagnosis and therapy

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 665, P. 124687 - 124687

Published: Sept. 10, 2024

Language: Английский

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Intracellular Chemical Reaction‐Induced Self‐Assembly for the Construction of Artificial Architecture and Its Functions

Advanced NanoBiomed Research, Journal Year: 2024, Volume and Issue: 4(4)

Published: Feb. 6, 2024

Intracellular assemblies play vital roles in maintaining cellular functions through structural recognition‐mediated interactions. The introduction of artificial structures has garnered substantial interest modulating via activation/inhibition interactions with biomacromolecules. However, the uptake these high‐molecular‐weight may limit their performance. Recently, intracellular chemical‐reaction‐induced self‐assembly emerged as a promising strategy for generating situ nanostructures biofunctionalities interacting This approach addresses challenge synthetic reactions occurring complex environments by utilizing diverse chemical that respond to endogenous and exogenous stimuli. review provides an overview latest advancements techniques. It focuses on responsiveness specific conditions, such redox overexpressed enzymes. Additionally, initiation stimuli, including reagents irradiation is explored. Polymerization‐induced hydrophobicity highlighted, leading into micro‐/nanostructures. These processes contribute construction materials morphologies, offering versatile functionalities biological applications.

Language: Английский

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Peptide-Based Low Molecular Weight Photosensitive Supramolecular Gelators

Gels, Journal Year: 2022, Volume and Issue: 8(9), P. 533 - 533

Published: Aug. 25, 2022

Over the last couple of decades, stimuli-responsive supramolecular gels comprising synthetic short peptides as building blocks have been explored for various biological and material applications. Though a wide range stimuli has tested depending on structure peptides, light stimulus attracted extensive attention due to its non-invasive, non-contaminant, remotely controllable nature, precise spatial temporal resolution, wavelength tunability. The integration molecular photo-switch low-molecular-weight may thus provide access self-assembled systems, notably gels, which be used create dynamic, light-responsive "smart" materials with variety structures functions. This review summarizes recent advancement in area light-sensitive peptide gelation. At first, glimpse commonly photo-switches is given, followed by detailed description their incorporation into sequences design mechanism action. Finally, challenges future perspectives developing next-generation photo-responsive are outlined.

Language: Английский

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Understanding multicomponent low molecular weight gels from gelators to networks

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: April 1, 2024

The construction of gels from low molecular weight gelators (LMWG) has been extensively studied in the fields bio-nanotechnology and other fields. However, understanding gaps still prevent prediction LMWG full design those gel systems. Gels with multicomponent become even more complicated because multiple interference effects coexist composite This review emphasizes systems view on (MLMWGs), summarizes recent progress desired networks MLMWGs, including self-sorting co-assembly, as well challenges approaches to hope that opportunities natural products peptides can speed up process close between structures. is focused three key concepts. Firstly, requires a perspective MLMWGs. Secondly, several protocols be applied control co-assembly behaviors system, certain complementary structures, chirality inducing dynamic control. Thirdly, discussion anchored strategies some examples are provided for constructed small subtle designed short peptides.

Language: Английский

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Stimuli-Responsive Prodrugs with Self-Immolative Linker for Improved Cancer Therapy

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 279, P. 116928 - 116928

Published: Sept. 30, 2024

Language: Английский

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Peptide-Based Materials That Exploit Metal Coordination

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 24(1), P. 456 - 456

Published: Dec. 27, 2022

Metal–ion coordination has been widely exploited to control the supramolecular behavior of a variety building blocks into functional materials. In particular, peptides offer great chemical diversity for metal-binding modes, combined with inherent biocompatibility and biodegradability that make them attractive especially medicine, sensing, environmental remediation. The focus this review is last 5 years’ progress in exciting field conclude an overview future directions research area currently undertaking.

Language: Английский

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Hierarchical Self‐Assembly of Short Peptides: Nanostructure Formation, Function Tailoring, and Applications

Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

This article explores the hierarchical self-assembly of short peptides, which refers to structured spatial arrangements these molecules over long distances. phenomenon is commonly found in nature and has important implications for biological structure function. Short peptides are preferred because they have ability spontaneously create various nanostructures. process, known as bottom-up assembly, allows addition functional groups at carboxyl or amine ends peptides. These enable specific functions that extremely valuable fields biotechnology biomedicine. text discusses basic processes involved such characteristics amino acid side chains, categorization according their chemical structure, influence intermolecular forces, dynamic process. In addition, paper uses disciplines biomedicine optoelectronics, including stimulus-responsive hydrogels, tissue engineering, drug delivery. The also suggests rational design principles controlling creating new commercial applications, particularly with offers insights into future discipline.

Language: Английский

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Harnessing Amino Acid Modularity for Programmable Function in Covalent Peptide Assemblies

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Covalent peptide assembly leverages robust covalent bonds and dynamic non-covalent interactions to provide enhanced stability introduce diverse functionalities. Nevertheless, it remains significantly challenging achieve modular control over the structural diversity functional complexity while elucidating how specific amino acid sequences contribute these processes. Here, systematic encoding of derivative characteristics is demonstrated through modularity enable precise both in assemblies. By systematically screening single substitutions pentapeptides using tyrosine crosslinking, a library constructs developed. Each construct tailored exhibit distinct properties, including charge repulsion, aggregation-induced quenching, disassembly behavior, redox responsiveness. The strategic manipulation sequence composition, individual assemblies combinatorial systems, enables programmable complexity. This approach yields various module-specific functions, frustrated growth, hierarchical hollow architecture formation, affinity enrichment, stimuli-responsive fluorescence signal amplification. work establishes framework for design materials with functionalities, advancing development next-generation multicomponent technologies characterized by unprecedented adaptability.

Language: Английский

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