Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(15), С. 10217 - 10233
Опубликована: Апрель 2, 2024
Although
immunotherapy
is
relatively
effective
in
treating
hematological
malignancies,
their
efficacy
against
solid
tumors
still
suboptimal
or
even
noneffective
presently.
Compared
to
cancers,
exhibit
strikingly
different
immunosuppressive
microenvironment,
severely
deteriorating
the
of
immunotherapy:
(1)
chemical
features
such
as
hypoxia
and
mild
acidity
suppress
activity
immune
cells,
(2)
pro-tumorigenic
domestication
cells
microenvironment
within
further
undermines
effectiveness
immunotherapy,
(3)
dense
physical
barrier
tumor
tissues
prevents
intratumoral
infiltration
contact
killing
active
cells.
Therefore,
we
believe
that
reversing
are
critical
priority
for
tumors.
Due
unique
morphologies,
structures,
compositions,
nanomedicines
have
become
powerful
tools
achieving
this
goal.
In
Perspective,
will
first
briefly
introduce
then
summarize
most
recent
progresses
nanomedicine-based
by
remodeling
immune-microenvironment
a
comprehensive
manner.
It
highly
expected
Perspective
aid
advancing
tumors,
optimistic
on
future
development
burgeoning
field.
Nano-Micro Letters,
Год журнала:
2022,
Номер
14(1)
Опубликована: Июль 18, 2022
As
the
indispensable
second
cellular
messenger,
calcium
signaling
is
involved
in
regulation
of
almost
all
physiological
processes
by
activating
specific
target
proteins.
The
importance
ions
(Ca
Journal of the American Chemical Society,
Год журнала:
2022,
Номер
144(10), С. 4667 - 4677
Опубликована: Март 7, 2022
Constructing
artificial
dynamic
architectures
inside
cells
to
rationally
interfere
with
organelles
is
emerging
as
an
efficient
strategy
regulate
the
behaviors
and
fate
of
cells,
thus
providing
new
routes
for
therapeutics.
Herein,
we
develop
intracellular
K+-mediating
assembly
DNA
tetrahedrons
which
realizes
mitochondrial
interference
consequent
regulation
on
energy
metabolism
living
cells.
In
designer
tetrahedron,
one
vertex
was
modified
triphenylphosphine
(TPP)
targeting,
other
three
vertexes
were
tethered
guanine-rich
sequences
that
could
realize
formation
intermolecular
G-quadruplexes,
consequently
led
form
aggregates
in
cytoplasm.
The
specially
targeted
mitochondria
served
a
polyanionic
barrier
substance
communication,
generating
significant
inhibition
effect
aerobic
respiration
function
associated
glycolysis
process,
reduced
production
adenosine
triphosphate
(ATP).
lack
ATP
impeded
lamellipodium
essential
movement
resulting
inhibitory
cell
migration.
Remarkably,
migration
capacity
suppressed
by
high
50%
cancer
This
work
provides
manipulation
via
endogenous
molecule-mediating
exogenous
envisioned
have
great
potential
precise
biomedicine.
Advanced Materials,
Год журнала:
2023,
Номер
35(31)
Опубликована: Фев. 22, 2023
Abstract
Nanomedicine‐enabled/augmented
ultrasound
(US)
medicine
is
a
unique
area
of
interdisciplinary
research
that
focuses
on
designing
and
engineering
functional
nanosystems
to
address
the
challenging
issues
in
US‐based
biomedicine,
overcoming
shortcomings
traditional
microbubbles
optimizing
design
contrast
sonosensitive
agents.
The
single‐faceted
summary
available
US‐related
therapies
still
significant
drawback.
Here,
proposal
comprehensive
review
recent
advances
nanomaterials
advancing
four
biological
applications
disease
theranostics
aimed.
In
addition
mostly
explored
nanomedicine‐enabled/augmented
sonodynamic
therapy
(SDT),
discussion
other
sono‐therapies
progresses/achievements
are
relatively
lacking,
including
sonomechanical
(SMT),
sonopiezoelectric
(SPT),
sonothermal
(STT).
concepts
specific
based
nanomedicines
initially
introduced.
Furthermore,
representative
paradigms
for
nanomedicine‐enabled/enhanced
US
elaborated
according
therapeutic
principles
diversity.
This
provides
an
updated
field
nanoultrasonic
comprehensively
discusses
progress
versatile
ultrasonic
treatments.
Finally,
deep
facing
challenges
prospects
expected
promote
emergence
establishment
new
branch
biomedicine
through
rational
combination
nanomedicine
clinical
biomedicine.
Abstract
Metal‐based
nanomaterials
have
attracted
broad
attention
recently
due
to
their
unique
biological
physical
and
chemical
properties
after
entering
tumor
cells,
namely
effects.
In
particular,
the
abilities
of
Ca
2+
modulate
T
cell
receptors
activation,
K
+
regulate
stem
differentiation,
Mn
activate
STING
pathway,
Fe
2+/3+
induce
ferroptosis
enhance
catalytic
therapy,
make
metal
ions
metal‐based
play
crucial
roles
in
cancer
treatments.
Therefore,
superior
advantages
characteristics
microenvironment,
we
will
summarize
recent
progress
anti‐tumor
effects
nanomaterials.
Based
on
different
this
review
mainly
focuses
following
five
aspects:
(1)
metal‐enhanced
radiotherapy
sensitization,
(2)
(3)
ferroptosis,
(4)
pyroptosis,
(5)
immunotherapy.
At
same
time,
shortcomings
therapy
are
also
discussed,
future
research
directions
been
prospected.
The
highlights
promising
biosafety,
potent
efficacy
for
in‐depth
various
mechanism
studies
provide
novel
ideas
application
RSC Advances,
Год журнала:
2023,
Номер
13(21), С. 14443 - 14460
Опубликована: Янв. 1, 2023
This
review
summarizes
the
common
inorganic
and
organic
photothermal
nanoagents
their
applications
in
tumor
therapy.
Additionally,
challenges
future
prospects
of
nanomaterial-based
therapy
cancer
treatment
are
discussed.
ACS Nano,
Год журнала:
2022,
Номер
16(7), С. 11428 - 11443
Опубликована: Июль 11, 2022
The
regulation
of
intracellular
ions'
overload
to
interrupt
normal
bioprocesses
and
cause
cell
death
has
been
developed
as
an
efficient
strategy
(named
ion-interference
therapy/IIT)
treat
cancer.
In
this
study,
we
design
a
multifunctional
nanoplatform
(called
BSArGO@ZIF-8
NSs)
by
in
situ
growth
metal
organic
framework
nanoparticles
(ZIF-8
NPs)
onto
the
graphene
oxide
(GO)
surface,
subsequently
reduced
ascorbic
acid
modified
bovine
serum
albumin.
This
nanocomplex
causes
Zn2+,
increase
reactive
oxygen
species
(ROS),
exerts
broad-spectrum
lethality
different
kinds
cancer
cells.
NSs
can
promote
apoptosis
initiating
bim
(a
pro-apoptotic
protein)-mediated
mitochondrial
apoptotic
events,
up-regulating
PUMA/NOXA
expression,
down-regulating
level
Bid/p53AIP1.
Meanwhile,
Zn2+
excess
triggers
cellular
dysfunction
mitochondria
damage
activating
autophagy
signaling
pathways
disturbing
environmental
homeostasis.
Combined
with
photothermal
effect
GO
(rGO),
mediated
combined
therapy
leads
effective
inhibits
proliferation
angiogenesis,
bringing
higher
efficacy
tumor
suppression
vivo.
designed
Zn-based
will
allow
promoting
further
development
IIT
corresponding
strategy.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(40)
Опубликована: Авг. 17, 2023
Abstract
Although
immunotherapy
has
a
broad
clinical
application
prospect,
it
is
still
hindered
by
low
immune
responses
and
immunosuppressive
tumor
microenvironment.
Herein,
simple
drug‐free
inorganic
nanomaterial,
alkalescent
sodium
bicarbonate
nanoparticles
(NaHCO
3
NPs),
prepared
via
fast
microemulsion
method
for
amplified
cancer
immunotherapy.
The
obtained
NaHCO
regulates
lactic
acid
metabolism
through
acid‐base
neutralization
so
as
to
reverse
the
mildly
acidic
environment.
Additionally,
can
further
release
high
amounts
of
Na
+
ions
inside
cells
induce
surge
in
intracellular
osmolarity,
thus
activate
pyroptosis
pathway
immunogenic
cell
death
(ICD),
damage‐associated
molecular
patterns
(DAMPs)
inflammatory
factors,
improve
responses.
Collectively,
NPs
observably
inhibit
primary/distal
growth
metastasis
remitted
immunosuppression
induced
activation,
showing
an
enhanced
antitumor
immunity
efficiency.
This
work
provides
new
paradigm
mediated
treatment,
which
potential
