Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Окт. 19, 2023
Abstract
Immunotherapy
has
good
potential
to
eradicate
tumors
in
the
long
term.
However,
due
low
immunogenicity
of
tumor
cells,
current
cancer
immunotherapies
are
not
effective.
To
address
this
limitation,
we
constructed
a
BSA-FA
functionalized
iron-containing
metal-organic
framework
(TPL@TFBF)
that
triggers
potent
systemic
anti-tumor
immune
response
by
inducing
ferroptosis
and
pyroptosis
cells
releasing
large
quantities
damage-associated
molecular
patterns
(DAMPs)
induce
immunogenicity,
showing
excellent
efficacy
against
melanoma
lung
metastases
vivo.
This
nanoplatform
forms
through
coordination
between
tannic
acid
(TA)
Fe
3+
is
then
loaded
with
triptolide
(TPL),
which
coated
FA-modified
BSA.
The
nanoparticles
target
FA
modification,
TPL,
TA.
reduced
2+
TA,
triggering
Fenton
reaction
resulting
ROS
production.
Moreover,
TPL
increases
production
intracellular
inhibiting
expression
nuclear
factor
erythroid-2
related
(Nrf2).
Such
simultaneous
amplification
induces
undergo
pyroptosis,
amounts
DAMPs,
stimulate
antigen
presentation
dendritic
(DCs)
proliferation
cytotoxic
T
lymphocytes
(CD4+/CD8
+
cells)
inhibit
metastasis.
In
addition,
combining
nanoparticle
treatment
checkpoint
blockade
(ICB)
further
inhibits
growth.
work
provides
new
strategy
for
immunotherapy
based
on
various
combinations
cell
death
mechanisms.
Advanced Materials,
Год журнала:
2024,
Номер
36(24)
Опубликована: Фев. 7, 2024
Abstract
Increasing
cellular
immunogenicity
and
reshaping
the
immune
tumor
microenvironment
(TME)
are
crucial
for
antitumor
immunotherapy.
Herein,
this
work
develops
a
novel
single‐atom
nanozyme
pyroptosis
initiator:
UK5099
pyruvate
oxidase
(POx)‐co‐loaded
Cu‐NS
(Cu‐NS@UK@POx),
that
not
only
trigger
through
cascade
biocatalysis
to
boost
of
cells,
but
also
remodel
immunosuppressive
TME
by
targeting
metabolism.
By
replacing
N
with
weakly
electronegative
S,
original
spatial
symmetry
Cu‐N
4
electron
distribution
is
changed
enzyme‐catalyzed
process
effectively
regulated.
Compared
spatially
symmetric
nanozymes
(Cu‐N
SA),
S‐doped
asymmetric
(Cu‐NS
SA)
exhibit
stronger
activities,
including
peroxidase
(POD),
nicotinamide
adenine
dinucleotide
(NADH)
(NOx),
L
‐cysteine
(LCO),
glutathione
(GSHOx),
which
can
cause
enough
reactive
oxygen
species
(ROS)
storms
pyroptosis.
Moreover,
synergistic
effect
SA,
UK5099,
POx
target
metabolism,
improves
increases
degree
This
study
provides
two‐pronged
treatment
strategy
significantly
activate
immunotherapy
effects
via
ROS
storms,
NADH/glutathione/
consumption,
oxidation,
lactic
acid
(LA)/ATP
depletion,
triggering
regulating
broad
vision
expanding
Cancer Gene Therapy,
Год журнала:
2024,
Номер
31(7), С. 970 - 983
Опубликована: Март 29, 2024
Abstract
This
comprehensive
review
explores
the
intricate
mechanisms
of
PANoptosis
and
its
implications
in
cancer.
PANoptosis,
a
convergence
apoptosis,
pyroptosis,
necroptosis,
plays
crucial
role
cell
death
immune
response
regulation.
The
study
delves
into
molecular
pathways
each
mechanism
their
crosstalk
within
emphasizing
shared
components
like
caspases
PANoptosome
complex.
It
highlights
significant
various
cancers,
including
respiratory,
digestive,
genitourinary,
gliomas,
breast
showing
impact
on
tumorigenesis
patient
survival
rates.
We
further
discuss
interwoven
relationship
between
tumor
microenvironment
(TME),
illustrating
how
influences
behavior
progression.
underscores
dynamic
interplay
tumors
microenvironments,
focusing
roles
different
cells
interactions
with
cancer
cells.
Moreover,
presents
new
breakthroughs
therapy,
potential
targeting
to
enhance
anti-tumor
immunity.
outlines
strategies
manipulate
for
therapeutic
purposes,
such
as
key
signaling
molecules
caspases,
NLRP3,
RIPK1,
RIPK3.
novel
treatments
immunogenic
PANoptosis-initiated
therapies
nanoparticle-based
is
also
explored.
Abstract
Sonodynamic
therapy
(SDT)
has
been
explored
for
cancer
therapy,
especially
deep
tumors
due
to
its
low
tissue
penetration
restriction.
The
therapeutic
efficacy
of
SDT
is
limited
the
complicated
tumor
microenvironment.
This
study
reports
construction
oxygen‐carrying
semiconducting
polymer
nanoprodrugs
(OSPN
pro
)
treatment
via
combining
amplified
with
pyroptosis.
An
oxygen
carrier
perfluorohexane,
sonodynamic
as
sonosensitizer,
and
reactive
species
(ROS)‐responsive
prodrug
are
co‐loaded
into
a
nanoparticle
system,
leading
formation
these
nanoprodrugs.
Such
OSPN
show
an
effective
accumulation
in
tissues
after
systemic
administration,
which
they
deliver
relieve
hypoxia
microenvironment
thus
mediate
producing
ROS
under
ultrasound
(US)
irradiation,
even
when
covered
2‐cm
chicken
breast
tissue.
In
addition,
ROS‐responsive
prodrugs
activated
by
generated
trigger
pyroptosis
cells.
sono‐pyroptosis
induces
strong
antitumor
immunity
obviously
higher
level
infiltrations
effector
immune
cells
tumors.
Therefore,
‐based
combinational
can
greatly
inhibit
growth
tissue‐covered
suppress
metastasis.
offers
nanoplatform
strategy.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Март 7, 2024
Abstract
Immune
checkpoint
blockers
(ICBs)
have
been
applied
for
cancer
therapy
and
achieved
great
success
in
the
field
of
immunotherapy.
Nevertheless,
broad
application
ICBs
is
limited
by
low
response
rate.
To
address
this
issue,
increasing
studies
found
that
induction
immunogenic
cell
death
(ICD)
tumor
cells
becoming
an
emerging
therapeutic
strategy
treatment,
not
only
straightly
killing
but
also
enhancing
dying
immunogenicity
activating
antitumor
immunity.
ICD
a
generic
term
representing
different
modes
containing
ferroptosis,
pyroptosis,
autophagy
apoptosis.
Traditional
chemotherapeutic
agents
usually
inhibit
growth
based
on
apoptotic
ICD,
most
are
resistant
to
Thus,
non-apoptotic
considered
be
more
efficient
approach
therapy.
In
addition,
due
ineffective
localization
inducers,
various
types
nanomaterials
being
developed
achieve
targeted
delivery
improved
immunotherapeutic
efficiency.
review,
we
briefly
outline
molecular
mechanisms
pyroptosis
autophagy,
as
well
their
reciprocal
interactions
with
immunity,
then
summarize
current
progress
ICD-induced
nanoparticles
strategies
illustrate
applications
Graphical
ACS Nano,
Год журнала:
2024,
Номер
18(19), С. 12386 - 12400
Опубликована: Май 3, 2024
Current
cancer
vaccines
face
challenges
due
to
an
immunosuppressive
tumor
microenvironment
and
their
limited
ability
produce
effective
immune
response.
To
address
the
above
limitations,
we
develop
a
3-(2-spiroadamantyl)-4-methoxy-4-(3-phosphoryloxy)-phenyl-1,2-dioxetane
(alkaline
phosphatase
substrate)
XMD8-92
(extracellular
signal-regulated
kinase
5
inhibitor)-codelivered
copper-tetrahydroxybenzoquinone
(Cu-THBQ/AX)
nanosized
metal–organic
framework
in
situ-generate
therapeutic
vaccination.
Once
inside
early
endosome,
alkaline
overexpressed
cells'
membrane
activates
situ
type
I
photodynamic
effect
of
Cu-THBQ/AX
for
generating
•O2–,
catalyzes
O2
H2O2
•O2–
•OH
via
semiquinone
radical
catalysis
Fenton-like
reactions.
This
surge
ROS
endosomes
triggers
caspase-3-mediated
proinflammatory
pyroptosis
activating
phospholipase
C.
Meanwhile,
can
also
induce
oligomerization
dihydrolipoamide
S-acetyltransferase
trigger
cell
cuproptosis.
The
production
could
release
effectively
inhibiting
efferocytosis
macrophages
convert
apoptosis
cells
into
secondary
necrosis.
simultaneous
induction
pyroptosis,
cuproptosis,
necrosis
converts
from
"cold"
"hot"
conditions,
making
it
antigen
pool.
transformation
successfully
antitumor
response,
growth
metastasis.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(8), С. 2006 - 2014
Опубликована: Янв. 1, 2024
A
mitochondrial
targeting
copper
dithiocarbamate
induces
intense
immunogenic
cuproptosis
in
cancer
cells
and
macrophage
M1
polarization.
This
emphasizes
the
potential
of
inducers
immunotherapy.
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 2, 2025
Despite
the
promising
clinical
applications
of
immunotherapy,
its
effectiveness
is
often
limited
by
low
immune
responses
and
tumor
escape.
In
this
study,
we
introduce
a
simple
drug-free
inorganic
nanomaterial,
sodium
succinate
(C4H4Na2O4
NPs),
prepared
using
rapid
microemulsion
method
to
enhance
cancer
immunotherapy.
The
synthesized
C4H4Na2O4
NPs
can
release
high
concentrations
Na+
ions
into
cells,
leading
an
increase
in
intracellular
osmolarity.
This
triggers
pyroptosis
pathway,
resulting
cellular
contents,
inflammatory
factors,
damage-associated
molecular
patterns,
which
ultimately
boost
responses.
Furthermore,
inhibit
escape
through
upregulating
major
histocompatibility
complex-I
(MHC-I)
expression.
Collectively,
significantly
growth
metastasis
pyroptosis-induced
activation
MHC-I
expression
upregulation-remitted
research
offers
novel
approach
treatment
that
leverages
pyroptosis,
demonstrating
potential
for
application
Journal of Nanobiotechnology,
Год журнала:
2022,
Номер
20(1)
Опубликована: Окт. 23, 2022
Abstract
Due
to
the
urgent
demand
for
more
anti-cancer
methods,
new
applications
of
metal
ions
in
cancer
have
attracted
increasing
attention.
Especially
three
kinds
mode
cell
death,
including
ferroptosis,
calcicoptosis,
and
cuproptosis,
are
great
concern.
Meanwhile,
many
been
found
induce
death
through
different
approaches,
such
as
interfering
with
osmotic
pressure,
triggering
biocatalysis,
activating
immune
pathways,
generating
prooxidant
effect.
Therefore,
varieties
strategies
based
on
above
approaches
studied
applied
applications.
Moreover,
contrast
agents
gradually
become
core
components
bioimaging
technologies,
MRI,
CT,
fluorescence
imaging,
which
exhibit
guiding
significance
diagnosis.
Besides,
nano-theranostic
platforms
experimentally
shown
efficient
response
endogenous
exogenous
stimuli,
realizes
simultaneous
therapy
diagnosis
a
controlled
nano-system.
However,
most
metal-based
still
early
stages,
clinical
trials
necessary
confirm
or
not
current
expectations.
This
article
will
focus
these
explorations
ions,
hoping
provide
some
theoretical
support
ideas.
