Rational design of an ultrabright quinolinium-fused rhodamine turn-on fluorescent probe for highly sensitive detection of SO2 derivatives: applications in food safety and bioimaging
Journal of Hazardous Materials,
Год журнала:
2024,
Номер
480, С. 136291 - 136291
Опубликована: Окт. 24, 2024
Язык: Английский
Rationally Manipulating Molecular Planarity to Improve Molar Absorptivity, NIR-II Brightness, and Photothermal Effect for Tumor Phototheranostics
Biomaterials,
Год журнала:
2025,
Номер
318, С. 123113 - 123113
Опубликована: Янв. 17, 2025
Язык: Английский
Synchronously Manipulating the D−A Interaction and Planarity in Semiconducting Polymers to Achieve 84.7% Photothermal Conversion Efficiency for NIR‐II Imaging‐Guided Tumor Therapy
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(44)
Опубликована: Июль 18, 2024
Abstract
Exploiting
photothermal
agents
with
second‐near‐infrared
(NIR‐II,
1000−1700
nm)
emission
and
a
high
conversion
efficiency
(PCE)
is
an
appealing
challenging
task.
Herein,
by
simultaneously
tailoring
the
D−A
interaction
planarity
in
fluorophores,
two
donor‐acceptor
(D−A)
−type
semiconducting
polymers
(SPs),
T‐BTP
B‐BTP,
are
constructed.
Compared
T‐BTP,
B‐BTP
shows
increased
intramolecular
interactions
improved
molecular
planarity,
leading
to
bathochromic‐shift
absorption,
NIR‐II
emission,
PCE.
Notably,
NPs
achieve
remarkable
PCE
of
84.7%,
which
among
highest
PCEs
SPs
fluorescence
imaging‐guided
therapy
(PTT).
Because
these
promising
features,
successfully
used
vascular
imaging
cancer
therapy.
This
study
provides
valuable
guidelines
for
development
high‐performance
SPs.
Язык: Английский
Carbonic Anhydrase IX Targeted Polyaspartamide fluorescent Probes for Tumor imaging
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 639 - 651
Опубликована: Янв. 1, 2025
Precise
intraoperative
tumor
delineation
is
essential
for
successful
surgical
outcomes.
However,
conventional
methods
are
often
incompetent
to
provide
guidance
due
lack
specificity
and
sensitivity.
Recently
fluorescence-guided
surgery
tumors
delineate
between
cancerous
healthy
tissues
has
attracted
widespread
attention.
The
contrast-enhanced
fluorescent
imaging
been
applied
non-invasive
diagnosis
of
cancers
using
tumor-targeting
probes.
carbonic
anhydrase
IX
targeted
polyaspartamide
compounds
(SD-PHEA-NI)
were
synthesized
by
incorporating
a
group
sulfadiazine
(SD)
N-butyl-4-ethyldiamino-1,8-naphthalimide
(NI)
into
water-soluble
carriersof
poly-α,β-[N-(2-hydroxyethyl)-L-aspartamide]
(PHEA).
These
derivatives
also
characterized
Fourier
transform
infrared
spectroscopy,
gel
permeation
chromatography,
ultraviolet-visible
nuclear
magnetic
resonance
spectroscopy
fluorescence
assays.
cellular
uptake,
cytotoxicity,
ability
evaluated.
Experiment
results
indicated
that
SD-PHEA-NI
low
cytotoxic
Henrietta
Lacks
(HeLa)
cells.
Moreover,
B16F10
melanoma
cells
can
take
up
show
good
green
images.
displayed
low-intensity
signal
in
human
embryonic
kidney
(293T)
be
considered
potential
probe
the
detection
tumors.
This
study
enhance
image-guided
interventions
providing
real-time
information
robust
decision
support,
thereby
reducing
recurrence
complication
rates
ultimately
improving
patient
Язык: Английский
De novo design of dual-detection fluorescent sensors for bisulfite and copper (II) ion based on cascade activation
Tian Tan,
Wenyu Xi,
Chenxu Duan
и другие.
Analytica Chimica Acta,
Год журнала:
2025,
Номер
1346, С. 343789 - 343789
Опубликована: Фев. 10, 2025
Язык: Английский
Dual-Locked Near-Infrared Fluorescent Probe for Real-Time Imaging of Hydrogen Sulfide/Matrix Metallopeptidase-2 In Vivo
ACS Nano,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 12, 2025
Hydrogen
sulfide
(H2S)
and
matrix
metallopeptidase
2
(MMP-2)
are
inextricably
linked
in
the
occurrence
development
of
diseases
treatment
diseases.
However,
most
activatable
imaging
probes
currently
developed
single-locked
that
do
not
simultaneously
detect
H2S
MMP-2
levels
at
disease
sites
severely
hinder
real-time
accurate
analysis
dynamic
relationship
between
two
interrelated
biomarkers.
Herein,
we
report
a
dual-locked
H2S/MMP-2-activatable
near-infrared
(NIR)
fluorescent
probe
through
dual-Förster
resonance
energy
transfer
(FRET)
mechanism
specifically
detects
tumors
or
acute
lung
injury
(ALI)
establishes
level
expression.
Initially,
fluorescence
is
turned
off
due
to
from
methylene
blue
(MB)
both
cationic
electrochromic
material
(dicationic
1,1,4,4-tetraarylbutadiene,
EM
12+)
quencher
QSY21.
Upon
reaction
with
H2S/MMP-2
ALI,
NIR
activated,
enabling
ALI.
Additionally,
this
precisely
tracks
effects
exogenous
glucocorticoids
for
ALI
on
expression,
providing
powerful
molecular
tool
early
prediction
outcomes
Язык: Английский
Albumin Modulated Homodimer as an Efficient Photosensitizer for Long‐Term Imaging‐Guided Tumor Therapy Directed with Sunlight Irradiation
Zan Li,
Xiunan Xie,
Zhihao Lu
и другие.
Small,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 17, 2025
Abstract
The
reactive
oxygen
species
(ROS)
amplification
caused
by
inevitable
plasma
albumin
encapsulation
is
still
a
challenge
to
circumvent
the
systemic
adverse
effects
in
photodynamic
therapy
(PDT)
process.
Herein,
disulfide
bond
linked
homodimer,
Cy1280,
which
modulated
accurately
balance
fluorescence
and
ROS
generation
exhibit
weak
sealed
PDT
effect
during
blood
circulation,
exploited.
Cy1280
can
be
specifically
internalized
dispersed
at
tumor
site
via
Organic
Anion
Transporter
Proteins
(OATPs)
thiol‐disulfide
exchange
mediated
synergistic
uptake
activated
after
mild
sunlight
irradiation
(100
±
5
Klx)
sensitize
neighboring
cellular
mitochondria
execute
direct
protein
dysfunction
effect.
dynamic
covalent
chemistry
(DCC)
facilitates
prolonged
sustained
retention
tumors
(>336
h)
demonstrates
efficacy
of
imaging‐guided
solid‐tumor
tumor‐bearing
BALB/C
mice.
This
study
resolves
stubborn
impotent
penetration
bulky‐sized
nanoparticles
high
interstitial
pressure
with
manner,
long‐term
circulation
manipulated
also
improve
whole
body
phototoxic
symptom.
advantageous
feature
provides
promising
candidate
for
overcoming
off‐target
phototoxicity
inadequate
accumulation
challenges
clinical
translation
photosensitizers
(PSs).
Язык: Английский
Tumor Site‐Specific In Vivo Theranostics Enabled by Microenvironment‐Dependent Chemical Transformation and Self‐Amplifying Effect
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 29, 2024
Abstract
Precise
tumor
diagnosis
and
treatment
remain
complex
challenges.
While
numerous
fluorescent
probes
have
been
developed
for
tumor‐specific
imaging
therapy,
few
exhibit
effective
function
in
vivo.
Herein,
a
probe
called
TQ‐H
2
is
designed
that
can
realize
robust
theranostic
effects
both
vitro
In
vitro,
specifically
targets
the
lysosome
reacts
with
hydroxyl
radical
(·OH)
to
generate
TQ‐HA,
which
lights
up
cells.
TQ‐HA
generates
reactive
oxygen
species
(ROS)
under
light
irradiation,
enabling
simultaneous
induction
monitoring
of
apoptosis
ferroptosis
Remarkably,
also
acts
as
self‐amplifier,
autocatalytically
activating
by
generating
·OH
exposure.
This
self‐amplification
aligns
microenvironment,
where
undergoes
chemical
transformation,
distinguishing
tumors
from
healthy
tissue
via
near‐infrared
(NIR)
fluorescence
imaging.
Furthermore,
ROS
generated
effectively
kills
cells
inhibits
growth
without
harming
normal
study
offers
promising
strategy
targeted
theranostics
using
self‐amplifying
microenvironment‐responsive
probes.
Язык: Английский
Construction of a Dual-Mode Sensing Platform for Ultra-fast and Real-time Detection of Bisulfite in Food and Environmental Systems
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 6, 2024
Abstract
Sulfur
dioxide
(SO
2)
is
widely
used
in
food
processing
to
extend
the
shelf
life
of
food.
However,
excessive
intake
SO
2
and
its
derivatives
(HSO
3-
SO
32-)
can
cause
oxidative
damage
body,
resulting
several
diseases.
How
construct
probes
for
rapid
real-time
detection
HSO
3-
field
beneficial
developmental
needs
practical
applications,
but
it
also
very
challenging.
Here
we
report
a
dual-mode
fluorescent
probe
Rh-QL
ultrafast
HSO
3-,
which
undergoes
specific
1,4-Michael
addition
reaction
with
sulfite
achieve
Near-infrared
fluorescence
turn-on.
Probe
was
able
detect
within
5
s
significant
color
change
from
violet
green
strong
signal
at
700
nm.
The
has
been
HSO
3-
in
real
sugar
samples
be
prepared
as
portable
sensing
kit
environment
due
high
efficiency,
rapidity
accuracy.
In
addition,
target
label
Gram-negative
bacteria
after
reacting
potential
identify
type
pathogenic
bacteria.
Язык: Английский