Construction of a Dual-Mode Sensing Platform for Ultra-fast and Real-time Detection of Bisulfite in Food and Environmental Systems DOI Creative Commons
Xiaoyu Huang, Jiaxing Li,

Qiutong Chen

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Abstract Sulfur dioxide (SO2) is widely used in food processing to extend the shelf life of food. However, excessive intake SO2 and its derivatives (HSO3- SO32-) can cause oxidative damage body, resulting several diseases. How construct probes for rapid real-time detection HSO3- field beneficial developmental needs practical applications, but it also very challenging. Here we report a dual-mode fluorescent probe Rh-QL ultrafast HSO3-, which undergoes specific 1,4-Michael addition reaction with sulfite achieve Near-infrared fluorescence turn-on. Probe was able detect within 5 s significant color change from violet green strong signal at 700 nm. The has been HSO3- in real sugar samples be prepared as portable sensing kit environment due high efficiency, rapidity accuracy. In addition, target label Gram-negative bacteria after reacting potential identify type pathogenic bacteria.

Language: Английский

Rational design of an ultrabright quinolinium-fused rhodamine turn-on fluorescent probe for highly sensitive detection of SO2 derivatives: applications in food safety and bioimaging DOI
Jiaxing Li,

Mingyu Tian,

Tianruo Shen

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136291 - 136291

Published: Oct. 24, 2024

Language: Английский

Citations

24
Rationally Manipulating Molecular Planarity to Improve Molar Absorptivity, NIR-II Brightness, and Photothermal Effect for Tumor Phototheranostics DOI

Chaoqi Song,

Shiping Yang,

Yajing Chi

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123113 - 123113

Published: Jan. 17, 2025

Language: Английский

Citations

1
Synchronously Manipulating the D−A Interaction and Planarity in Semiconducting Polymers to Achieve 84.7% Photothermal Conversion Efficiency for NIR‐II Imaging‐Guided Tumor Therapy DOI

Xiankun Hu,

Qian Jia, Qiyu Fang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)

Published: July 18, 2024

Abstract Exploiting photothermal agents with second‐near‐infrared (NIR‐II, 1000−1700 nm) emission and a high conversion efficiency (PCE) is an appealing challenging task. Herein, by simultaneously tailoring the D−A interaction planarity in fluorophores, two donor‐acceptor (D−A) −type semiconducting polymers (SPs), T‐BTP B‐BTP, are constructed. Compared T‐BTP, B‐BTP shows increased intramolecular interactions improved molecular planarity, leading to bathochromic‐shift absorption, NIR‐II emission, PCE. Notably, NPs achieve remarkable PCE of 84.7%, which among highest PCEs SPs fluorescence imaging‐guided therapy (PTT). Because these promising features, successfully used vascular imaging cancer therapy. This study provides valuable guidelines for development high‐performance SPs.

Language: Английский

Citations

4
Carbonic Anhydrase IX Targeted Polyaspartamide fluorescent Probes for Tumor imaging DOI Creative Commons
Yu Zhang, Fan Liu,

Chuntao Shao

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 639 - 651

Published: Jan. 1, 2025

Precise intraoperative tumor delineation is essential for successful surgical outcomes. However, conventional methods are often incompetent to provide guidance due lack specificity and sensitivity. Recently fluorescence-guided surgery tumors delineate between cancerous healthy tissues has attracted widespread attention. The contrast-enhanced fluorescent imaging been applied non-invasive diagnosis of cancers using tumor-targeting probes. carbonic anhydrase IX targeted polyaspartamide compounds (SD-PHEA-NI) were synthesized by incorporating a group sulfadiazine (SD) N-butyl-4-ethyldiamino-1,8-naphthalimide (NI) into water-soluble carriersof poly-α,β-[N-(2-hydroxyethyl)-L-aspartamide] (PHEA). These derivatives also characterized Fourier transform infrared spectroscopy, gel permeation chromatography, ultraviolet-visible nuclear magnetic resonance spectroscopy fluorescence assays. cellular uptake, cytotoxicity, ability evaluated. Experiment results indicated that SD-PHEA-NI low cytotoxic Henrietta Lacks (HeLa) cells. Moreover, B16F10 melanoma cells can take up show good green images. displayed low-intensity signal in human embryonic kidney (293T) be considered potential probe the detection tumors. This study enhance image-guided interventions providing real-time information robust decision support, thereby reducing recurrence complication rates ultimately improving patient

Language: Английский

Citations

0
De novo design of dual-detection fluorescent sensors for bisulfite and copper (II) ion based on cascade activation DOI

Tian Tan,

Wenyu Xi,

Chenxu Duan

et al.

Analytica Chimica Acta, Journal Year: 2025, Volume and Issue: 1346, P. 343789 - 343789

Published: Feb. 10, 2025

Language: Английский

Citations

0
Dual-Locked Near-Infrared Fluorescent Probe for Real-Time Imaging of Hydrogen Sulfide/Matrix Metallopeptidase-2 In Vivo DOI
Luyan Wu, Qiang Tong,

Xiang Cao

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Hydrogen sulfide (H2S) and matrix metallopeptidase 2 (MMP-2) are inextricably linked in the occurrence development of diseases treatment diseases. However, most activatable imaging probes currently developed single-locked that do not simultaneously detect H2S MMP-2 levels at disease sites severely hinder real-time accurate analysis dynamic relationship between two interrelated biomarkers. Herein, we report a dual-locked H2S/MMP-2-activatable near-infrared (NIR) fluorescent probe through dual-Förster resonance energy transfer (FRET) mechanism specifically detects tumors or acute lung injury (ALI) establishes level expression. Initially, fluorescence is turned off due to from methylene blue (MB) both cationic electrochromic material (dicationic 1,1,4,4-tetraarylbutadiene, EM 12+) quencher QSY21. Upon reaction with H2S/MMP-2 ALI, NIR activated, enabling ALI. Additionally, this precisely tracks effects exogenous glucocorticoids for ALI on expression, providing powerful molecular tool early prediction outcomes

Language: Английский

Citations

0
Albumin Modulated Homodimer as an Efficient Photosensitizer for Long‐Term Imaging‐Guided Tumor Therapy Directed with Sunlight Irradiation DOI Open Access
Zan Li,

Xiunan Xie,

Zhihao Lu

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Abstract The reactive oxygen species (ROS) amplification caused by inevitable plasma albumin encapsulation is still a challenge to circumvent the systemic adverse effects in photodynamic therapy (PDT) process. Herein, disulfide bond linked homodimer, Cy1280, which modulated accurately balance fluorescence and ROS generation exhibit weak sealed PDT effect during blood circulation, exploited. Cy1280 can be specifically internalized dispersed at tumor site via Organic Anion Transporter Proteins (OATPs) thiol‐disulfide exchange mediated synergistic uptake activated after mild sunlight irradiation (100 ± 5 Klx) sensitize neighboring cellular mitochondria execute direct protein dysfunction effect. dynamic covalent chemistry (DCC) facilitates prolonged sustained retention tumors (>336 h) demonstrates efficacy of imaging‐guided solid‐tumor tumor‐bearing BALB/C mice. This study resolves stubborn impotent penetration bulky‐sized nanoparticles high interstitial pressure with manner, long‐term circulation manipulated also improve whole body phototoxic symptom. advantageous feature provides promising candidate for overcoming off‐target phototoxicity inadequate accumulation challenges clinical translation photosensitizers (PSs).

Language: Английский

Citations

0
Tumor Site‐Specific In Vivo Theranostics Enabled by Microenvironment‐Dependent Chemical Transformation and Self‐Amplifying Effect DOI Creative Commons
Yunfei Zuo, Pei Li,

Wenjin Wang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

Abstract Precise tumor diagnosis and treatment remain complex challenges. While numerous fluorescent probes have been developed for tumor‐specific imaging therapy, few exhibit effective function in vivo. Herein, a probe called TQ‐H 2 is designed that can realize robust theranostic effects both vitro In vitro, specifically targets the lysosome reacts with hydroxyl radical (·OH) to generate TQ‐HA, which lights up cells. TQ‐HA generates reactive oxygen species (ROS) under light irradiation, enabling simultaneous induction monitoring of apoptosis ferroptosis Remarkably, also acts as self‐amplifier, autocatalytically activating by generating ·OH exposure. This self‐amplification aligns microenvironment, where undergoes chemical transformation, distinguishing tumors from healthy tissue via near‐infrared (NIR) fluorescence imaging. Furthermore, ROS generated effectively kills cells inhibits growth without harming normal study offers promising strategy targeted theranostics using self‐amplifying microenvironment‐responsive probes.

Language: Английский

Citations

1
Construction of a Dual-Mode Sensing Platform for Ultra-fast and Real-time Detection of Bisulfite in Food and Environmental Systems DOI Creative Commons
Xiaoyu Huang, Jiaxing Li,

Qiutong Chen

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Abstract Sulfur dioxide (SO2) is widely used in food processing to extend the shelf life of food. However, excessive intake SO2 and its derivatives (HSO3- SO32-) can cause oxidative damage body, resulting several diseases. How construct probes for rapid real-time detection HSO3- field beneficial developmental needs practical applications, but it also very challenging. Here we report a dual-mode fluorescent probe Rh-QL ultrafast HSO3-, which undergoes specific 1,4-Michael addition reaction with sulfite achieve Near-infrared fluorescence turn-on. Probe was able detect within 5 s significant color change from violet green strong signal at 700 nm. The has been HSO3- in real sugar samples be prepared as portable sensing kit environment due high efficiency, rapidity accuracy. In addition, target label Gram-negative bacteria after reacting potential identify type pathogenic bacteria.

Language: Английский

Citations

0