Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer

Chemical Society Reviews, Год журнала: 2018, Номер 48(7), С. 2053 - 2108

Опубликована: Сен. 27, 2018

The nonradiative conversion of light energy into heat (photothermal therapy, PTT) or sound (photoacoustic imaging, PAI) has been intensively investigated for the treatment and diagnosis cancer, respectively. By taking advantage nanocarriers, both imaging therapeutic functions together with enhanced tumour accumulation have thoroughly studied to improve pre-clinical efficiency PAI PTT. In this review, we first summarize development inorganic organic nano photothermal transduction agents (PTAs) strategies improving PTT outcomes, including applying appropriate laser dosage, guiding via techniques, developing PTAs absorption in second NIR window, increasing (PCE), also tumours. Second, introduce advantages combining other therapies cancer treatment. Third, emerging applications cancer-related research are exemplified. Finally, perspectives challenges combating especially regarding their clinical translation, discussed. We believe that having noteworthy features would become promising next-generation non-invasive theranostic techniques our ability combat cancers.

Язык: Английский

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Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation

Chemical Society Reviews, Год журнала: 2018, Номер 48(1), С. 38 - 71

Опубликована: Ноя. 2, 2018

Recent progress in developing organic semiconducting materials (OSMs) for deep-tissue optical imaging, cancer phototherapy and biological photoactivation is summarized.

Язык: Английский

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Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery

Advanced Materials, Год журнала: 2019, Номер 31(24)

Опубликована: Апрель 26, 2019

Fluorescence bioimaging affords a vital tool for both researchers and surgeons to molecularly target variety of biological tissues processes. This review focuses on summarizing organic dyes emitting at transparency window termed the near-infrared-II (NIR-II) window, where minimal light interaction with surrounding allows photons travel nearly unperturbed throughout body. NIR-II fluorescence imaging overcomes penetration/contrast bottleneck in visible region, making it remarkable modality early diagnosis cancer highly sensitive tumor surgery. Due their convenient bioconjugation peptides/antibodies, molecular are desirable candidates targeted imaging, significantly overcoming autofluorescence/scattering issues deep tissue imaging. To promote clinical translation bioimaging, advancements high-performance small molecule-derived probes critically important. Here, molecules potential discussed, synthesis chemical structures dyes, optical properties behavior whole body detection surgery, as well microscopy A key perspective direction surgery is also discussed.

Язык: Английский

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Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications

Journal of the American Chemical Society, Год журнала: 2020, Номер 142(35), С. 14789 - 14804

Опубликована: Авг. 7, 2020

Fluorescence imaging has become a fundamental tool for biomedical applications; nevertheless, its intravital capacity in the conventional wavelength range (400–950 nm) been restricted by extremely limited tissue penetration. To tackle this challenge, novel approach using fluorescence second near-infrared window (NIR-II, 1000–1700 developed past decade to achieve deep penetration and high-fidelity imaging, thus significant applications have begun emerge. In Perspective, we first examine recent discoveries challenges development of NIR-II fluorophores compatible apparatuses. Subsequently, advances bioimaging, biosensing, therapy such cutting-edge technique are highlighted. Finally, based on achievement representative studies, elucidate main concerns regarding give some advice prospects future applications.

Язык: Английский

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Second near-infrared photothermal materials for combinational nanotheranostics

Chemical Society Reviews, Год журнала: 2020, Номер 50(2), С. 1111 - 1137

Опубликована: Ноя. 27, 2020

This review summarizes the recent development of second near-infrared photothermal combinational nanotheranostics for cancer, infectious diseases and regenerative medicine.

Язык: Английский

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Recent Advances of Optical Imaging in the Second Near‐Infrared Window

Advanced Materials, Год журнала: 2018, Номер 30(47)

Опубликована: Сен. 4, 2018

Abstract The near‐infrared window between 1000 and 1700 nm, commonly termed the “second (NIR‐II) window,” has quickly emerged as a highly attractive optical region for biological imaging. In contrast to conventional imaging in visible 400 700 well first NIR (NIR‐I) 900 NIR‐II offers numerous merits, including higher spatial resolution, deeper penetration depth, lower absorption scattering from substrates with minimal tissue autofluorescence. Noninvasive techniques, specifically fluorescence photoacoustic (PA) imaging, have embodied attractiveness of several agents demonstrating superior performance clinically approved NIR‐I agents. Consequently, been increasingly explored due its tremendous potential preclinical studies clinical utility. Herein, progress is reported. Starting highlighting importance spectral region, emergence latest development various PA probes their applications are then discussed. Perspectives on promises challenges facing this nascent yet exciting field given.

Язык: Английский

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Design of superior phototheranostic agents guided by Jablonski diagrams

Chemical Society Reviews, Год журнала: 2020, Номер 49(22), С. 8179 - 8234

Опубликована: Янв. 1, 2020

Phototheranostics represents a promising direction for modern precision medicine, which has recently attracted great research interest from multidisciplinary areas. Organic optical agents including small molecular fluorophores, semiconducting/conjugated polymers, aggregation-induced emission luminogens, etc. with tuneable photophysical properties, high biosafety and biocompatibility, facile processability ease of functionalization have delivered encouraging performance in disease phototheranostics. This review summarizes the recent progress organic phototheranostic an emphasis on main strategies to manipulate three excitation energy dissipation pathways, namely, radiative decay, thermal deactivation, intersystem crossing, assistance Jablonski diagram, particularly showcases how diagram been guiding design molecule aggregate levels promote outcomes. Molecular nanoengineering modulate processes convert absorbed photons into fluorescent/phosphorescent/photoacoustic signals and/or photodynamic/photothermal curing effects improved phototheranostics are elaborated. Noteworthily, adaptive activatable transformable functions demand, regulation such as chemiexcitation efficacies also included. A brief summary discussion current challenges future perspectives this field is further presented.

Язык: Английский

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Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

Advanced Materials, Год журнала: 2018, Номер 31(6)

Опубликована: Дек. 17, 2018

Abstract Photoacoustic (PA) imaging as a fast‐developing technique has great potential in biomedical and clinical applications. It is noninvasive modality that depends on the light‐absorption coefficient of imaged tissue injected PA‐imaging contrast agents. Furthermore, PA provides superb contrast, super spatial resolution, high penetrability sensitivity to functional characteristics by detecting acoustic wave construct images. In recent years, series agents are developed improve performance Here, progress their applications outlined. classified according components function, gold nanocrystals, gold‐nanocrystal assembly, transition‐metal chalcogenides/MXene‐based nanomaterials, carbon‐based other inorganic agents, small organic molecules, semiconducting polymer nanoparticles, nonlinear discussed. The biosensors (in sensing metal ions, pH, enzymes, temperature, hypoxia, reactive oxygen species, nitrogen species) bioimaging (lymph nodes, vasculature, tumors, brain tissue) discussed detail. Finally, an outlook future research investigation significance presented.

Язык: Английский

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Dual‐Peak Absorbing Semiconducting Copolymer Nanoparticles for First and Second Near‐Infrared Window Photothermal Therapy: A Comparative Study

Advanced Materials, Год журнала: 2018, Номер 30(14)

Опубликована: Фев. 19, 2018

Near-infrared (NIR) light is widely used for noninvasive optical diagnosis and phototherapy. However, current research focuses on the first NIR window (NIR-I, 650-950 nm), while second (NIR-II, 1000-1700 nm) far less exploited. The development of organic photothermal nanoagent (SPNI-II ) with dual-peak absorption in both windows its utilization therapy (PTT) are reported herein. Such a comprises semiconducting copolymer two distinct segments that respectively identically absorb at 808 1064 nm. With conversion efficiency 43.4% nm generally higher than other inorganic nanomaterials, SPNI-II enables superior deep-tissue heating over their respective safety limits. Model cancer PTT tissue depth 5 mm validates enhanced antitumor effect when shifting laser irradiation from NIR-I to NIR-II window. good biodistribution facile synthesis also allow it be doped an dye fluorescence-imaging-guided through systemic administration. Thus, this study paves way new polymeric nanomaterials advance

Язык: Английский

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Optical nano-agents in the second near-infrared window for biomedical applications

Chemical Society Reviews, Год журнала: 2018, Номер 48(1), С. 22 - 37

Опубликована: Ноя. 16, 2018

This review summarizes the recent advances of optical nano-agents for various biomedical applications in NIR-II window.

Язык: Английский

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