Nano Letters,
Journal Year:
2017,
Volume and Issue:
18(1), P. 586 - 594
Published: Dec. 8, 2017
Photodynamic
nanotheranostics
has
shown
great
promise
for
cancer
therapy;
however,
its
therapeutic
efficacy
is
limited
due
to
the
hypoxia
of
tumor
microenvironment
and
unfavorable
bioavailability
existing
photodynamic
agents.
We
herein
develop
hybrid
core–shell
semiconducting
nanoparticles
(SPN-Ms)
that
can
undergo
O2
evolution
in
hypoxic
solid
promote
process.
Such
oxygenic
are
synthesized
through
a
one-pot
surface
growth
reaction
have
unique
multilayer
structure
cored
coated
with
polymer
(SPNs)
manganese
dioxide
(MnO2)
nanosheets,
respectively.
The
SPN
core
serves
as
both
NIR
fluorescence
imaging
agent,
while
MnO2
nanosheets
act
sacrificing
component
convert
H2O2
under
acidic
microenvironment.
As
compared
uncoated
(SPN-0),
(SPN-M1)
generate
2.68-fold
more
1O2
at
conditions
laser
irradiation
808
nm.
Because
such
an
oxygen-evolution
property,
SPN-M1
effectively
eradicate
cells
vitro
vivo.
Our
study
thus
not
only
reports
situ
synthetic
method
coat
organic
but
also
develops
tumor-microenvironment-sensitive
theranostic
nanoagent
overcome
amplified
therapy.
Chemical Society Reviews,
Journal Year:
2018,
Volume and Issue:
48(7), P. 2053 - 2108
Published: Sept. 27, 2018
The
nonradiative
conversion
of
light
energy
into
heat
(photothermal
therapy,
PTT)
or
sound
(photoacoustic
imaging,
PAI)
has
been
intensively
investigated
for
the
treatment
and
diagnosis
cancer,
respectively.
By
taking
advantage
nanocarriers,
both
imaging
therapeutic
functions
together
with
enhanced
tumour
accumulation
have
thoroughly
studied
to
improve
pre-clinical
efficiency
PAI
PTT.
In
this
review,
we
first
summarize
development
inorganic
organic
nano
photothermal
transduction
agents
(PTAs)
strategies
improving
PTT
outcomes,
including
applying
appropriate
laser
dosage,
guiding
via
techniques,
developing
PTAs
absorption
in
second
NIR
window,
increasing
(PCE),
also
tumours.
Second,
introduce
advantages
combining
other
therapies
cancer
treatment.
Third,
emerging
applications
cancer-related
research
are
exemplified.
Finally,
perspectives
challenges
combating
especially
regarding
their
clinical
translation,
discussed.
We
believe
that
having
noteworthy
features
would
become
promising
next-generation
non-invasive
theranostic
techniques
our
ability
combat
cancers.
Chemical Society Reviews,
Journal Year:
2018,
Volume and Issue:
48(1), P. 38 - 71
Published: Nov. 2, 2018
Recent
progress
in
developing
organic
semiconducting
materials
(OSMs)
for
deep-tissue
optical
imaging,
cancer
phototherapy
and
biological
photoactivation
is
summarized.
Advanced Materials,
Journal Year:
2019,
Volume and Issue:
31(24)
Published: April 26, 2019
Fluorescence
bioimaging
affords
a
vital
tool
for
both
researchers
and
surgeons
to
molecularly
target
variety
of
biological
tissues
processes.
This
review
focuses
on
summarizing
organic
dyes
emitting
at
transparency
window
termed
the
near-infrared-II
(NIR-II)
window,
where
minimal
light
interaction
with
surrounding
allows
photons
travel
nearly
unperturbed
throughout
body.
NIR-II
fluorescence
imaging
overcomes
penetration/contrast
bottleneck
in
visible
region,
making
it
remarkable
modality
early
diagnosis
cancer
highly
sensitive
tumor
surgery.
Due
their
convenient
bioconjugation
peptides/antibodies,
molecular
are
desirable
candidates
targeted
imaging,
significantly
overcoming
autofluorescence/scattering
issues
deep
tissue
imaging.
To
promote
clinical
translation
bioimaging,
advancements
high-performance
small
molecule-derived
probes
critically
important.
Here,
molecules
potential
discussed,
synthesis
chemical
structures
dyes,
optical
properties
behavior
whole
body
detection
surgery,
as
well
microscopy
A
key
perspective
direction
surgery
is
also
discussed.
Journal of the American Chemical Society,
Journal Year:
2020,
Volume and Issue:
142(35), P. 14789 - 14804
Published: Aug. 7, 2020
Fluorescence
imaging
has
become
a
fundamental
tool
for
biomedical
applications;
nevertheless,
its
intravital
capacity
in
the
conventional
wavelength
range
(400–950
nm)
been
restricted
by
extremely
limited
tissue
penetration.
To
tackle
this
challenge,
novel
approach
using
fluorescence
second
near-infrared
window
(NIR-II,
1000–1700
developed
past
decade
to
achieve
deep
penetration
and
high-fidelity
imaging,
thus
significant
applications
have
begun
emerge.
In
Perspective,
we
first
examine
recent
discoveries
challenges
development
of
NIR-II
fluorophores
compatible
apparatuses.
Subsequently,
advances
bioimaging,
biosensing,
therapy
such
cutting-edge
technique
are
highlighted.
Finally,
based
on
achievement
representative
studies,
elucidate
main
concerns
regarding
give
some
advice
prospects
future
applications.
Chemical Society Reviews,
Journal Year:
2020,
Volume and Issue:
50(2), P. 1111 - 1137
Published: Nov. 27, 2020
This
review
summarizes
the
recent
development
of
second
near-infrared
photothermal
combinational
nanotheranostics
for
cancer,
infectious
diseases
and
regenerative
medicine.
Advanced Materials,
Journal Year:
2018,
Volume and Issue:
30(47)
Published: Sept. 4, 2018
Abstract
The
near‐infrared
window
between
1000
and
1700
nm,
commonly
termed
the
“second
(NIR‐II)
window,”
has
quickly
emerged
as
a
highly
attractive
optical
region
for
biological
imaging.
In
contrast
to
conventional
imaging
in
visible
400
700
well
first
NIR
(NIR‐I)
900
NIR‐II
offers
numerous
merits,
including
higher
spatial
resolution,
deeper
penetration
depth,
lower
absorption
scattering
from
substrates
with
minimal
tissue
autofluorescence.
Noninvasive
techniques,
specifically
fluorescence
photoacoustic
(PA)
imaging,
have
embodied
attractiveness
of
several
agents
demonstrating
superior
performance
clinically
approved
NIR‐I
agents.
Consequently,
been
increasingly
explored
due
its
tremendous
potential
preclinical
studies
clinical
utility.
Herein,
progress
is
reported.
Starting
highlighting
importance
spectral
region,
emergence
latest
development
various
PA
probes
their
applications
are
then
discussed.
Perspectives
on
promises
challenges
facing
this
nascent
yet
exciting
field
given.
Chemical Society Reviews,
Journal Year:
2020,
Volume and Issue:
49(22), P. 8179 - 8234
Published: Jan. 1, 2020
Phototheranostics
represents
a
promising
direction
for
modern
precision
medicine,
which
has
recently
attracted
great
research
interest
from
multidisciplinary
areas.
Organic
optical
agents
including
small
molecular
fluorophores,
semiconducting/conjugated
polymers,
aggregation-induced
emission
luminogens,
etc.
with
tuneable
photophysical
properties,
high
biosafety
and
biocompatibility,
facile
processability
ease
of
functionalization
have
delivered
encouraging
performance
in
disease
phototheranostics.
This
review
summarizes
the
recent
progress
organic
phototheranostic
an
emphasis
on
main
strategies
to
manipulate
three
excitation
energy
dissipation
pathways,
namely,
radiative
decay,
thermal
deactivation,
intersystem
crossing,
assistance
Jablonski
diagram,
particularly
showcases
how
diagram
been
guiding
design
molecule
aggregate
levels
promote
outcomes.
Molecular
nanoengineering
modulate
processes
convert
absorbed
photons
into
fluorescent/phosphorescent/photoacoustic
signals
and/or
photodynamic/photothermal
curing
effects
improved
phototheranostics
are
elaborated.
Noteworthily,
adaptive
activatable
transformable
functions
demand,
regulation
such
as
chemiexcitation
efficacies
also
included.
A
brief
summary
discussion
current
challenges
future
perspectives
this
field
is
further
presented.
Advanced Materials,
Journal Year:
2018,
Volume and Issue:
31(6)
Published: Dec. 17, 2018
Abstract
Photoacoustic
(PA)
imaging
as
a
fast‐developing
technique
has
great
potential
in
biomedical
and
clinical
applications.
It
is
noninvasive
modality
that
depends
on
the
light‐absorption
coefficient
of
imaged
tissue
injected
PA‐imaging
contrast
agents.
Furthermore,
PA
provides
superb
contrast,
super
spatial
resolution,
high
penetrability
sensitivity
to
functional
characteristics
by
detecting
acoustic
wave
construct
images.
In
recent
years,
series
agents
are
developed
improve
performance
Here,
progress
their
applications
outlined.
classified
according
components
function,
gold
nanocrystals,
gold‐nanocrystal
assembly,
transition‐metal
chalcogenides/MXene‐based
nanomaterials,
carbon‐based
other
inorganic
agents,
small
organic
molecules,
semiconducting
polymer
nanoparticles,
nonlinear
discussed.
The
biosensors
(in
sensing
metal
ions,
pH,
enzymes,
temperature,
hypoxia,
reactive
oxygen
species,
nitrogen
species)
bioimaging
(lymph
nodes,
vasculature,
tumors,
brain
tissue)
discussed
detail.
Finally,
an
outlook
future
research
investigation
significance
presented.
Advanced Materials,
Journal Year:
2018,
Volume and Issue:
30(14)
Published: Feb. 19, 2018
Near-infrared
(NIR)
light
is
widely
used
for
noninvasive
optical
diagnosis
and
phototherapy.
However,
current
research
focuses
on
the
first
NIR
window
(NIR-I,
650-950
nm),
while
second
(NIR-II,
1000-1700
nm)
far
less
exploited.
The
development
of
organic
photothermal
nanoagent
(SPNI-II
)
with
dual-peak
absorption
in
both
windows
its
utilization
therapy
(PTT)
are
reported
herein.
Such
a
comprises
semiconducting
copolymer
two
distinct
segments
that
respectively
identically
absorb
at
808
1064
nm.
With
conversion
efficiency
43.4%
nm
generally
higher
than
other
inorganic
nanomaterials,
SPNI-II
enables
superior
deep-tissue
heating
over
their
respective
safety
limits.
Model
cancer
PTT
tissue
depth
5
mm
validates
enhanced
antitumor
effect
when
shifting
laser
irradiation
from
NIR-I
to
NIR-II
window.
good
biodistribution
facile
synthesis
also
allow
it
be
doped
an
dye
fluorescence-imaging-guided
through
systemic
administration.
Thus,
this
study
paves
way
new
polymeric
nanomaterials
advance
