Rh(III)-Catalyzed Successive C–H Activations of 2-Phenyl-3H-indoles and Cyclization Cascades to Construct Highly Fused Indole Heteropolycycles
Organic Letters,
Год журнала:
2023,
Номер
25(19), С. 3341 - 3346
Опубликована: Май 5, 2023
Rh(III)-catalyzed
successive
C-H
activations
of
2-phenyl-3H-indoles
and
cyclization
cascades
with
diazo
compounds
were
developed
to
construct
highly
fused
indole
heteropolycycles
a
broad
range
substrates
good
yields.
In
particular,
this
transformation
included
two
unusual
[3+3]
[4+2]
sequential
cascades,
in
which
the
compound
played
different
role
processes,
while
simultaneously
forming
polycyclic
scaffold
new
quaternary
carbon
center.
Язык: Английский
Modular Assembly of Pyrrolo[3,4-c]isoquinolines through Rh-Catalyzed Cascade C–H Activation/Annulation of O-Methyl Aryloximes with Maleimides
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(12), С. 8447 - 8457
Опубликована: Июнь 4, 2024
An
efficient
and
practical
strategy
for
the
construction
of
pyrrolo[3,4-
Язык: Английский
Mechanistic insights to define the directional role of hydrogen-bonding network between aryl oximes and propargyl alcohols in Rh(III) catalysis
Molecular Catalysis,
Год журнала:
2023,
Номер
550, С. 113448 - 113448
Опубликована: Сен. 15, 2023
Язык: Английский
Rh(II)-Catalyzed Selective C(sp3)–H/C(sp2)–H Bonds Cascade Insertion to Construct [6–8–6] Benzo-Fused Scaffold
T.X. Yu,
Feifei Fang,
Haowen Shou
и другие.
Organic Letters,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 10, 2024
The
fused
eight-membered
carbocycles
(EMCs)
play
vital
roles
in
the
medicinal
and
biological
investigations
of
many
natural
products
marketed
drugs.
traditional
synthesis
[6-8-6]
benzo-fused
derivatives
involves
multistep
reactions
low
yields,
making
development
a
one-step
method
more
challenging
work.
Here,
we
present
novel
strategy
for
construction
scaffold
from
propargyl
diazoacetates
substituted
with
benzyl-nitrogen
heterocyclic
ring
via
Rh(ll)-catalyzed
carbene/alkyne
metathesis
(CAM)
selective
C-H
bond
insertion.
This
exhibits
specific
substrate
scope,
simple
operation,
mild
reaction
conditions,
high
atom
efficiency.
Mechanistically,
process
sequential
CAM,
1,3-H-shift,
intramolecular
nucleophilic
attack,
C(sp
Язык: Английский