Rh(II)-Catalyzed Selective C(sp3)–H/C(sp2)–H Bonds Cascade Insertion to Construct [6–8–6] Benzo-Fused Scaffold DOI Creative Commons
T.X. Yu,

Feifei Fang,

Haowen Shou

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

The fused eight-membered carbocycles (EMCs) play vital roles in the medicinal and biological investigations of many natural products marketed drugs. traditional synthesis [6-8-6] benzo-fused derivatives involves multistep reactions low yields, making development a one-step method more challenging work. Here, we present novel strategy for construction scaffold from propargyl diazoacetates substituted with benzyl-nitrogen heterocyclic ring via Rh(ll)-catalyzed carbene/alkyne metathesis (CAM) selective C-H bond insertion. This exhibits specific substrate scope, simple operation, mild reaction conditions, high atom efficiency. Mechanistically, process sequential CAM, 1,3-H-shift, intramolecular nucleophilic attack, C(sp

Language: Английский

Rh(III)-Catalyzed Successive C–H Activations of 2-Phenyl-3H-indoles and Cyclization Cascades to Construct Highly Fused Indole Heteropolycycles DOI
Ju Gao,

Keyu Luo,

Xiaohui Wei

et al.

Organic Letters, Journal Year: 2023, Volume and Issue: 25(19), P. 3341 - 3346

Published: May 5, 2023

Rh(III)-catalyzed successive C-H activations of 2-phenyl-3H-indoles and cyclization cascades with diazo compounds were developed to construct highly fused indole heteropolycycles a broad range substrates good yields. In particular, this transformation included two unusual [3+3] [4+2] sequential cascades, in which the compound played different role processes, while simultaneously forming polycyclic scaffold new quaternary carbon center.

Language: Английский

Citations

13
Modular Assembly of Pyrrolo[3,4-c]isoquinolines through Rh-Catalyzed Cascade C–H Activation/Annulation of O-Methyl Aryloximes with Maleimides DOI

Yinsong Wu,

Yanan Liu,

Yangzilin Kong

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(12), P. 8447 - 8457

Published: June 4, 2024

An efficient and practical strategy for the construction of pyrrolo[3,4-

Language: Английский

Citations

3
Mechanistic insights to define the directional role of hydrogen-bonding network between aryl oximes and propargyl alcohols in Rh(III) catalysis DOI
Yi Wang, Ping Qi, Hui Gao

et al.

Molecular Catalysis, Journal Year: 2023, Volume and Issue: 550, P. 113448 - 113448

Published: Sept. 15, 2023

Language: Английский

Citations

1
Rh(II)-Catalyzed Selective C(sp3)–H/C(sp2)–H Bonds Cascade Insertion to Construct [6–8–6] Benzo-Fused Scaffold DOI Creative Commons
T.X. Yu,

Feifei Fang,

Haowen Shou

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

The fused eight-membered carbocycles (EMCs) play vital roles in the medicinal and biological investigations of many natural products marketed drugs. traditional synthesis [6-8-6] benzo-fused derivatives involves multistep reactions low yields, making development a one-step method more challenging work. Here, we present novel strategy for construction scaffold from propargyl diazoacetates substituted with benzyl-nitrogen heterocyclic ring via Rh(ll)-catalyzed carbene/alkyne metathesis (CAM) selective C-H bond insertion. This exhibits specific substrate scope, simple operation, mild reaction conditions, high atom efficiency. Mechanistically, process sequential CAM, 1,3-H-shift, intramolecular nucleophilic attack, C(sp

Language: Английский

Citations

0