Research progress in electrochemical/photochemical utilization of methanol as a C1 source

Green Chemistry, Год журнала: 2023, Номер 25(21), С. 8313 - 8327

Опубликована: Янв. 1, 2023

This review highlights the recent advances in various electrochemical and photochemical reactions using methanol as a sustainable C1 source.

Язык: Английский

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Multi-Functionality of Methanol in Sustainable Catalysis: Beyond Methanol Economy

ACS Catalysis, Год журнала: 2023, Номер 13(22), С. 15013 - 15053

Опубликована: Ноя. 6, 2023

Methanol is a fundamental feedstock and widely used in the chemical petroleum industries. It can serve as C1 source to make variety of C–C C–N bond formation dehydrogenative coupling products, which have important applications natural products drug discovery. A high hydrogen content (12.5 wt%) methanol makes it an effective H2 donor for transfer hydrogenation various reducible functional groups. plethora transition metal-based processes been developed using methanol. Notably, recent review articles focused on aspect However, more updated that examines challenges both C1-source H2-source organic transformations contributing concept economy has not presented yet. This Review summarizes (homogeneous, heterogeneous, photo-) catalyst system C-, N-, O-methylation ketones, alcohols, amides, nitriles, heterocyclic compounds, sulfones, amines, sulfonamides direct N-methylation nitro compounds under borrowing strategy N-formylation amines acceptorless dehydrogenation source. also covers insights into reaction mechanisms role carefully selected ligands metal catalysis activation incorporation -CD3, methylation molecules. Moreover, describes groups such aldehydes, alkynes, with detail.

Язык: Английский

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The α-trideuteromethylation of arylacetonitriles with deuterated methanol via deuterium autotransfer process catalyzed by a metal-ligand bifunctional iridium catalyst

Journal of Catalysis, Год журнала: 2024, Номер 430, С. 115301 - 115301

Опубликована: Янв. 18, 2024

Язык: Английский

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Iron- and Organo-Catalyzed Borrowing Hydrogen for the Stereoselective Construction of Tetrahydropyrans

Organic Letters, Год журнала: 2024, Номер 26(27), С. 5788 - 5793

Опубликована: Июнь 27, 2024

Stereocontrolled oxa-Michael additions are challenging, given the high reversibility of process, which ultimately leads to racemization newly formed stereocenters. When iron-catalyzed borrowing hydrogen from allylic alcohols was combined with a stereocontrolled organocatalytic addition, wide array chiral tetrahydropyrans were efficiently prepared. The reaction could be performed in diastereoselective manner pre-existing stereocenters or enantioselectively achiral substrates. key success reactivity iron complex, selective for alcohol dehydrogenation and irreversibly led final product.

Язык: Английский

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CO to Isonitrile Substitution in Iron Cyclopentadienone Complexes: A Class of Active Iron Catalysts for Borrowing Hydrogen Strategies

ACS Catalysis, Год журнала: 2024, Номер 14(10), С. 7795 - 7805

Опубликована: Май 6, 2024

Discovering active, cheap iron complexes for eco-compatible borrowing hydrogen transformations constitutes a real challenge. In this context, we developed family of isonitrile-substituted cyclopentadienone complexes. They were successfully applied in traditional amine alkylation with alcohols and, notably, the development photoactivated multicatalytic enantioselective allylic alcohol functionalization. Of importance, catalyst showing greater activity under photoirradiation differs from one most active conventional using chemical activation. This underscores importance incorporating isonitrile ligands readily customizable manner, resulting catalysts complementary reactivities. The characterization their physical properties was complemented by density functional theory calculations to enhance our understanding behavior. Given distinctive disclosed catalysts, application is poised pave way exploring challenging reactivities related catalytic processes.

Язык: Английский

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Direct use of methanol instead of formaldehyde or paraformaldehyde: Acceptorless dehydrogenative coupling for the synthesis of arylhydrazones catalyzed by a metal–ligand iridium bifunctional catalyst

Journal of Catalysis, Год журнала: 2024, Номер 438, С. 115685 - 115685

Опубликована: Авг. 3, 2024

Язык: Английский

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Demystifying the recent photochemical and electrochemical tricks on installing the magic methyl group: A comprehensive overview

Green Chemistry, Год журнала: 2024, Номер 26(14), С. 8161 - 8203

Опубликована: Янв. 1, 2024

The strategic installation of the “magic methyl” group has become highly desirable for drug discovery. This review summarized recent photochemical and electrochemical strategies in installing methyl group.

Язык: Английский

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Visible light mediated Iron-Catalyzed synthesis of C-3 alkylated Indoles, bisindolylmethanes and flavanones using alcohols

Tetrahedron Letters, Год журнала: 2023, Номер 119, С. 154428 - 154428

Опубликована: Март 3, 2023

Язык: Английский

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Nickel‐Catalyzed Chemodivergent Coupling of Alcohols: Efficient Routes to Access α,α‐Disubstituted Ketones and α‐Substituted Chalcones

Chemistry - A European Journal, Год журнала: 2024, Номер 30(15)

Опубликована: Янв. 17, 2024

Abstract Chemodivergent (de)hydrogenative coupling of primary and secondary alcohols is achieved utilizing an inexpensive nickel catalyst, (6‐OH‐bpy)NiCl 2 . This protocol demonstrates the synthesis branched carbonyl compounds, α , ‐disubstituted ketones, ‐substituted chalcones via borrowing hydrogen strategy acceptorless dehydrogenative coupling, respectively. A wide range aryl‐based are coupled with various in this tandem dehydrogenation/hydrogenation reaction. The along KO t Bu or K CO 3 governed selectivity for formation saturated ketones chalcones. preliminary mechanistic investigation confirms reversible dehydrogenation to carbonyls metal‐ligand cooperation (MLC) involvement radical intermediates during

Язык: Английский

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Shining a light on Fe-catalyzed borrowing hydrogen alkylation

Trends in Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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