I2-DMSO mediated tetra-functionalization of enaminones for the construction of novel furo[2′,3′:4,5]pyrimido[1,2-b]indazole skeletons via in situ capture of ketenimine cations

Chinese Chemical Letters, Год журнала: 2024, Номер 36(1), С. 109799 - 109799

Опубликована: Март 20, 2024

Язык: Английский

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I₂-DMSO mediated dual α,β-C(sp²)–H functionalization/bicyclization of o-hydroxyphenyl enaminones to construct C2,C3-disubstituted chromone derivatives: chromeno[2,3-b]pyrrol-4(1H)-ones

Organic Chemistry Frontiers, Год журнала: 2023, Номер 10(19), С. 4843 - 4847

Опубликована: Янв. 1, 2023

An unprecedented dual α,β-C(sp 2 )–H functionalization/bicyclization strategy of o -hydroxyphenyl enaminones for the preparation chromeno[2,3- b ]pyrrol-4(1 H )-ones has been established.

Язык: Английский

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Metal-free construction of dihydropyrazino[2,3-b]indoles from 2-aminoacetophenones, isocyanates and 1,2-diamines

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(10), С. 2043 - 2048

Опубликована: Янв. 1, 2024

A Brønsted acid/iodine co-mediated approach to construct dihydropyrazino[2,3-

Язык: Английский

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I₂-DMSO-Mediated Construction of 2,3- and 2,4-Disubstituted Pyrimido[1,2-b]indazole Skeletons

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(6), С. 3941 - 3953

Опубликована: Фев. 29, 2024

An efficient synthetic method for constructing 2,3- and 2,4-disubstituted pyrimidio[1,2-b]indazole skeletons through I2-DMSO-mediated substrate-controlled regioselective [4 + 2] cyclization is reported. The reaction conditions are mild, its operation simple, the substrate scope wide. More than 60 derivatives have been synthesized, providing a new methodology related molecules potentially enriching bioactive-molecule libraries.

Язык: Английский

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Construction of Pyrazolo[1,5-a]pyrimidines and Pyrimido[1,2-b]indazoles with Calcium Carbide as an Alkyne Source

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(28), С. 5822 - 5826

Опубликована: Янв. 1, 2024

One-step construction of both 5-arylpyrazolo[1,5- a ]pyrimidines and 2-arylpyrimido[1,2- b ]indazoles using inexpensive, abundant easy-to-handle calcium carbide as solid alkyne source is depicted.

Язык: Английский

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I₂–DMSO mediated multicomponent convergent synthesis of imidazo[2,1-a]isoquinoline derivatives via a triple in situ cross-trapping strategy

Organic Chemistry Frontiers, Год журнала: 2023, Номер 10(16), С. 4080 - 4085

Опубликована: Янв. 1, 2023

An I 2 –DMSO mediated one-pot approach to imidazo[2,1- a ]isoquinoline derivatives from readily available aryl methyl ketones and isoquinolin-1-amine has been demonstrated.

Язык: Английский

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I2–DMSO-mediated formal [3 + 1 + 2] synthesis of pyrimido[1,2-b]indazole using 1,4-dithiane-2,5-diol as a surrogate of ethylene

Tetrahedron Letters, Год журнала: 2025, Номер 156, С. 155453 - 155453

Опубликована: Янв. 9, 2025

Язык: Английский

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Modular and selective synthesis of pyrazolo-azepino-centred polycyclic aromatic and non-aromatic architectures

Organic Chemistry Frontiers, Год журнала: 2023, Номер 10(16), С. 4122 - 4130

Опубликована: Янв. 1, 2023

The pyrazolo-azepino-centred polyheterocyclic fused system is a privileged scaffold, but it lacks an effective synthetic approach, with modular synthesis being even more scarce.

Язык: Английский

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A Facile Ugi/Ullmann Cascade Reaction to Access Fused Indazolo-Quinoxaline Derivatives with Potent Anticancer Activity

Molecules, Год журнала: 2024, Номер 29(2), С. 464 - 464

Опубликована: Янв. 17, 2024

A facile methodology for the construction of a complex heterocycle indazolo-fused quinoxalinone has been developed via an Ugi four-component reaction (U-4CR) followed by intramolecular Ullmann reaction. The expeditious process features operationally simple approach, time efficiency, and broad substrate scope. Biological activity was evaluated demonstrated that compound 6e inhibits human colon cancer cell HCT116 proliferation with IC50 2.1 μM, suggesting potential applications developing drug lead in medicinal chemistry.

Язык: Английский

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Diastereoselective Double Annulation of Allenoates with Povarov Adducts: Modular Synthesis of Multisubstituted Pyrroloquinolines

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(22), С. 16838 - 16849

Опубликована: Ноя. 6, 2024

Herein, we report an atom-economical, one-pot, four-component, diastereoselective double-annulation reaction to construct polyfused pyrroloquinolines. This highlights the cyclization of in situ

Язык: Английский

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