Five-membered ring systems: With more than 1 N atom DOI
Larry Yet

Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 211 - 257

Published: Jan. 1, 2024

Language: Английский

I2-DMSO mediated tetra-functionalization of enaminones for the construction of novel furo[2′,3′:4,5]pyrimido[1,2-b]indazole skeletons via in situ capture of ketenimine cations DOI
You Zhou, Li‐Sheng Wang,

Shuang‐Gui Lei

et al.

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: 36(1), P. 109799 - 109799

Published: March 20, 2024

Language: Английский

Citations

10
I2-DMSO mediated dual α,β-C(sp2)–H functionalization/bicyclization of o-hydroxyphenyl enaminones to construct C2,C3-disubstituted chromone derivatives: chromeno[2,3-b]pyrrol-4(1H)-ones DOI

Shuang‐Gui Lei,

You Zhou, Li‐Sheng Wang

et al.

Organic Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 10(19), P. 4843 - 4847

Published: Jan. 1, 2023

An unprecedented dual α,β-C(sp 2 )–H functionalization/bicyclization strategy of o -hydroxyphenyl enaminones for the preparation chromeno[2,3- b ]pyrrol-4(1 H )-ones has been established.

Language: Английский

Citations

18
Metal-free construction of dihydropyrazino[2,3-b]indoles from 2-aminoacetophenones, isocyanates and 1,2-diamines DOI

Jingxi Fang,

Jiayao Fang,

Yingbo Rao

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(10), P. 2043 - 2048

Published: Jan. 1, 2024

A Brønsted acid/iodine co-mediated approach to construct dihydropyrazino[2,3-

Language: Английский

Citations

9
I2-DMSO-Mediated Construction of 2,3- and 2,4-Disubstituted Pyrimido[1,2-b]indazole Skeletons DOI
Linlin Ma, You Zhou,

Yong‐Xing Tang

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(6), P. 3941 - 3953

Published: Feb. 29, 2024

An efficient synthetic method for constructing 2,3- and 2,4-disubstituted pyrimidio[1,2-b]indazole skeletons through I2-DMSO-mediated substrate-controlled regioselective [4 + 2] cyclization is reported. The reaction conditions are mild, its operation simple, the substrate scope wide. More than 60 derivatives have been synthesized, providing a new methodology related molecules potentially enriching bioactive-molecule libraries.

Language: Английский

Citations

6
Construction of Pyrazolo[1,5-a]pyrimidines and Pyrimido[1,2-b]indazoles with Calcium Carbide as an Alkyne Source DOI

Xinjie You,

Botao Wang, Fei Wen

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(28), P. 5822 - 5826

Published: Jan. 1, 2024

One-step construction of both 5-arylpyrazolo[1,5- a ]pyrimidines and 2-arylpyrimido[1,2- b ]indazoles using inexpensive, abundant easy-to-handle calcium carbide as solid alkyne source is depicted.

Language: Английский

Citations

5
I2–DMSO mediated multicomponent convergent synthesis of imidazo[2,1-a]isoquinoline derivatives via a triple in situ cross-trapping strategy DOI

Yong‐Xing Tang,

Shi‐Yi Zhuang,

Jinyi Liu

et al.

Organic Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 10(16), P. 4080 - 4085

Published: Jan. 1, 2023

An I 2 –DMSO mediated one-pot approach to imidazo[2,1- a ]isoquinoline derivatives from readily available aryl methyl ketones and isoquinolin-1-amine has been demonstrated.

Language: Английский

Citations

9
I2–DMSO-mediated formal [3 + 1 + 2] synthesis of pyrimido[1,2-b]indazole using 1,4-dithiane-2,5-diol as a surrogate of ethylene DOI

Yong-Dong Du,

Jungang Wang, Jinyi Liu

et al.

Tetrahedron Letters, Journal Year: 2025, Volume and Issue: 156, P. 155453 - 155453

Published: Jan. 9, 2025

Language: Английский

Citations

0
Modular and selective synthesis of pyrazolo-azepino-centred polycyclic aromatic and non-aromatic architectures DOI
Ting Chen,

Jin‐Tian Ma,

Xiang‐Long Chen

et al.

Organic Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 10(16), P. 4122 - 4130

Published: Jan. 1, 2023

The pyrazolo-azepino-centred polyheterocyclic fused system is a privileged scaffold, but it lacks an effective synthetic approach, with modular synthesis being even more scarce.

Language: Английский

Citations

7
A Facile Ugi/Ullmann Cascade Reaction to Access Fused Indazolo-Quinoxaline Derivatives with Potent Anticancer Activity DOI Creative Commons
Yong Li, Liu‐Jun He,

Qin Hongxia

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(2), P. 464 - 464

Published: Jan. 17, 2024

A facile methodology for the construction of a complex heterocycle indazolo-fused quinoxalinone has been developed via an Ugi four-component reaction (U-4CR) followed by intramolecular Ullmann reaction. The expeditious process features operationally simple approach, time efficiency, and broad substrate scope. Biological activity was evaluated demonstrated that compound 6e inhibits human colon cancer cell HCT116 proliferation with IC50 2.1 μM, suggesting potential applications developing drug lead in medicinal chemistry.

Language: Английский

Citations

2
Diastereoselective Double Annulation of Allenoates with Povarov Adducts: Modular Synthesis of Multisubstituted Pyrroloquinolines DOI
Srinivasarao Yaragorla,

Doma Arun

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(22), P. 16838 - 16849

Published: Nov. 6, 2024

Herein, we report an atom-economical, one-pot, four-component, diastereoselective double-annulation reaction to construct polyfused pyrroloquinolines. This highlights the cyclization of in situ

Language: Английский

Citations

2