Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 30, 2024
A
visible-light-promoted
azidation/arylation
of
unactivated
alkenes
with
Togni-N
3
toward
a
series
azidated
pyrrolo[1,2-
]indoles
via
an
EDA
complex
as
the
key
intermediate.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(12), С. 6600 - 6624
Опубликована: Янв. 1, 2024
Dearomatization
has
emerged
as
a
powerful
tool
for
rapid
construction
of
3D
molecular
architectures
from
simple,
abundant,
and
planar
(hetero)arenes.
The
field
evolved
beyond
simple
dearomatization
driven
by
new
synthetic
technology
development.
With
the
renaissance
photocatalysis
expansion
activation
mode,
last
few
years
have
witnessed
impressive
developments
in
innovative
photochemical
methodologies,
enabling
skeletal
modifications
dearomatized
structures.
They
offer
truly
efficient
useful
tools
facile
highly
complex
structures,
which
are
viable
natural
product
synthesis
drug
discovery.
In
this
review,
we
aim
to
provide
mechanistically
insightful
overview
on
these
innovations
based
degree
alteration,
categorized
into
dearomative
functionalization
editing,
highlight
their
utilities.
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
27(22)
Опубликована: Апрель 16, 2024
Abstract
In
this
study,
we
present
an
efficient
and
straightforward
dearomative
hydroalkylation
of
indoles.
By
utilizing
alkanes
or
ethers
as
alkyl
radical
sources
employing
TBADT
a
cost‐effective
photocatalyst
for
direct
hydrogen
atom
transfers
(HAT),
achieved
successful
conversion
these
heterocyclic
derivatives
into
2‐alkylindolines
with
good
to
excellent
yields
high
diastereoselectivity
under
mild
reaction
conditions.
This
paper
reviews
progress
in
the
photochemical/electrochemical
construction
of
heterocyclic
compounds
using
CO
2
,
differentiating
between
various
reaction
types
and
elucidating
their
underlying
mechanisms
as
well
potential
applications.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 18, 2025
Chemical
utilization
of
carbon
dioxide
(CO2)
has
emerged
as
a
sustainable
access
for
synthesizing
high-value
chemicals.
Continuously
designing
the
more
practical
reaction
systems
is
large
importance.
Herein,
an
unprecedented
and
powerful
copper-PMHS
reductive
system
o-aminobenzamides
with
CO2
disclosed.
Synthetically,
diverse
range
quinazolinones
(>70
examples)
are
rapidly
assembled
excellent
functional
group
tolerance
in
good
yields.
Moreover,
building
other
types
heterocycles
such
benzothiazoles
benzimidazoles
also
allowable.
Mechanistically,
differing
from
reported
carbonylation
cases,
this
finding
represents
scarce
example
single-carbon
atom
synthon
PMHS
system.
Asian Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 28, 2025
Abstract
Dearomatization
offers
an
efficient
strategy
for
directly
converting
arenes
into
cyclic
molecules.
In
this
review,
we
discuss
representative
examples
of
dearomatization
reactions
through
five
modes:
(1)
radical
dearomatization,
(2)
halofunctionalization‐dearomatization,
in
which
three‐membered
intermediates
were
frequently
involved,
(3)
nucleophilic
mainly
about
electron‐rich
arenes,
(4)
oxidative
and
(5)
reductive
dearomatization.
Compared
to
heteroarenes,
simple
benzene
are
more
challenging
participate
reactions.
recent
years,
fewer
reports
have
focused
on
benzene.
Heteroarenes,
inherently
or
easily
activated,
tend
undergo
readily.
This
review
highlights
a
decade
progress
including
indoles,
benzofurans,
benzothiophenes,
thiophenes,
furans,
naphthols,
naphthalenes,
quinolines,
pyridines,
nitrobenzenes,
benzenes.
It
also
analyzes
their
mechanisms
strategies.
We
hope
will
aid
future
research
field.