Nickel-catalyzed cross-electrophile coupling of unactivated (hetero)aryl sulfone with aryl bromide

Journal of Catalysis, Год журнала: 2024, Номер 430, С. 115359 - 115359

Опубликована: Фев. 1, 2024

Язык: Английский

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Hydroxylation of Aryl Sulfonium Salts for Phenol Synthesis under Mild Reaction Conditions

Molecules, Год журнала: 2024, Номер 29(4), С. 831 - 831

Опубликована: Фев. 13, 2024

Hydroxylation of aryl sulfonium salts could be realized by utilizing acetohydroxamic acid and oxime as hydroxylative agents in the presence cesium carbonate a base, leading to variety structurally diverse hydroxylated arenes 47–95% yields. In addition, reaction exhibited broad functionality tolerance, range important functional groups (e.g., cyano, nitro, sulfonyl, formyl, keto, ester) well amenable mild conditions.

Язык: Английский

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Nickel-catalyzed cross-electrophile couplings of aryl fluorosulfates with vinyl chlorosilanes

Journal of Catalysis, Год журнала: 2024, Номер 437, С. 115636 - 115636

Опубликована: Июль 6, 2024

Язык: Английский

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Direct Cross-Couplings of Aryl Nonaflates with Aryl Bromides under Nickel Catalysis

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 30, 2025

The direct cross-couplings of aryl nonaflates with bromides could be successfully accomplished by utilizing nickel as the catalyst, magnesium metal mediator, and lithium chloride additive. reactions proceeded efficiently in THF at room temperature to produce desired biaryls moderate good yields, showing both a reasonable substrate scope functional group tolerance. Additionally, an equally performance realized when reaction was subjected scale-up synthesis. Preliminary study suggested that presumably proceeds through situ formation arylmagnesium reagent key intermediate.

Язык: Английский

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Cross-Electrophile Couplings of Benzyl Sulfonium Salts with Thiosulfonates via C–S Bond Activation

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(18), С. 13601 - 13607

Опубликована: Сен. 4, 2024

A zinc-mediated cross-electrophile coupling of benzyl sulfonium salts with thiosulfonates via C-S bond cleavage was achieved. The reductive thiolation proceeded well under transition metal-free conditions to afford the desired sulfides in good yields, exhibiting both broad substrate scope and functionality tolerance. In addition, reaction could be applied use selenosulfonate as an effective selenylation agent subjected scale-up synthesis.

Язык: Английский

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Molybdenum‐Catalyzed One‐Pot Multi‐Step Synthesis of N‐Polyheterocycles from Nitroarenes and Glycols

European Journal of Organic Chemistry, Год журнала: 2024, Номер 27(18)

Опубликована: Март 16, 2024

Abstract We report the efficient, sustainable one‐pot synthesis of a wide variety N ‐polyheterocycles, such as imidazo‐quinolines and quinoxalines, furoquinolines, from easily available nitroaromatics glycols via molybdenum catalytic domino reduction‐imine formation‐intramolecular cyclization‐oxidation sequence. It is worth highlighting that recycling incorporation waste carbonyl byproduct, generated in reduction step, into final compound realized. In addition, overall efficiency atom economy process are further improved owing to participation one reaction intermediate reductant allows lowering amount external reducing agent employed.

Язык: Английский

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CuH-Catalyzed Reductive Coupling of Nitroarenes with Phosphine Oxides for the Direct Synthesis of Phosphamides

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(11), С. 7848 - 7858

Опубликована: Май 29, 2024

A CuH-catalyzed reductive coupling of nitroarenes with phosphine oxides is developed, which produces a series phosphamides in moderate to excellent yields good functional group tolerance. Gram-scale synthesis and late-stage modification nitro-aromatic molecule niclosamide are also successfully conducted. The mechanism study shows that the nitro transformed after being reduced nitroso nucleophilic addition procedure involved during reaction.

Язык: Английский

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Sulfonylation of Pyridyl Phosphonium Salts with Sulfinate Salts in Aqueous Media for the Synthesis of 4-Pyridyl Sulfones via C–P Bond Cleavage

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Авг. 30, 2024

A Na

Язык: Английский

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Magnesium-Mediated Three-Component Reductive Cross-Couplings of Aryl Aldehydes, Aryl Bromides, and Aryl 2-Pyridyl Esters: An Efficient Synthesis of Diarylmethanol Esters

Tetrahedron, Год журнала: 2025, Номер unknown, С. 134558 - 134558

Опубликована: Фев. 1, 2025

Язык: Английский

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Synthesis of amides via TBN-induced oxidation cross-coupling of acetonitrile and N -sulfinylanilines

Synthetic Communications, Год журнала: 2025, Номер unknown, С. 1 - 9

Опубликована: Апрель 21, 2025

Язык: Английский

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