Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Июнь 19, 2024
Exosomes
are
a
subclass
of
extracellular
vesicles
shown
to
promote
the
cancer
growth
and
support
metastatic
progression.
The
proteomic
analysis
neuroblastoma-derived
exosomes
has
revealed
proteins
involved
in
cell
migration,
proliferation,
metastasis,
modulation
tumor
microenvironment
-
thus
contributing
development
an
aggressive
phenotype.
This
review
gives
overview
current
understanding
exosomal
neuroblastoma
their
potential
as
diagnostic/prognostic
biomarker
disease
therapeutics.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(9), С. 2236 - 2252
Опубликована: Янв. 1, 2024
Plant-derived
exosomes
(PDEs)
show
promising
potential
to
be
developed
as
a
therapeutic
agent
against
cancer,
owing
their
multiple
advantages
such
low
toxicity,
biocompatibility,
availability,
affordability,
etc.
The Journal of Liquid Biopsy,
Год журнала:
2024,
Номер
3, С. 100138 - 100138
Опубликована: Янв. 4, 2024
Extracellular
vesicles
(EVs)
are
the
cell's
secreted
component.
It
is
majorly
classified
into
microvesicles,
apoptotic
bodies,
and
exosomes.
Exosomes
play
a
significant
role
in
cancer
development
progression.
Its
molecular
signature
(DNA,
RNA,
Proteins,
lipids)
has
more
priority
profiling
current
decade.
In
prevention,
most
challenging
part
early
detection.
EVs-based
screening
develops
promising
platform.
Multi-Omics
exosomes
profiling-based
liquid
biopsy
support
detection
efficient
way.
This
approach
provides
detailed
expression
data
(it
may
be
inner
cargos
or
surface
express
molecules).
article
highlited
multi-omic
exosome
theranostics
applications
cancer,
technical
challenges,
improvisation
for
future
improvement.
ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(8), С. 8489 - 8506
Опубликована: Апрель 15, 2024
Cancer
is
the
most
challenging
health
complication
worldwide.
Scientific
society
has
tried
to
decode
its
complications
and
developing
a
smart
solution
for
mankind.
Extracellular
vesicles
(EVs)
are
an
emerging
frontier
in
cancer
research.
EVs
provide
fresh
insight
into
understanding
of
released
from
all
active
cells.
classified
some
major
classes,
such
as
apoptotic
bodies,
microvesicles,
exosomes.
Exosomes
among
exciting
tools
current
research
they
work
cellular
messengers
(which
reflects
cell's
healthy
or
pathological
conditional
status).
In
tumor
microenvironment,
regulate
several
complicated
events
uncontrolled
cell
growth,
immune
suppression,
angiogenesis,
extracellular
matrix
remodeling,
metastasis,
organ-specific
drug
therapeutic
resistance,
stem
development.
also
source
promising
biomarkers
involved
both
diagnosis
prognosis
performs
role.
Exosomes-based
nanomedicine
which
application
nanosize
theranostics
sensor
orientation,
supports
overcoming
management
limitations,
early
therapeutics
specific,
effective,
affordable.
this
review,
we
have
highlighted
integration
exosomes
nanotechnology
cutting-edge
approach
precision
oncology.
Clinical and Translational Discovery,
Год журнала:
2024,
Номер
4(1)
Опубликована: Янв. 28, 2024
Abstract
The
epithelial–mesenchymal
transition
(EMT)
represents
a
pivotal
frontier
in
oncology,
playing
central
role
the
metastatic
cascade
of
cancer—a
leading
global
health
challenge.
This
comprehensive
review
delves
into
complexities
EMT,
process
where
cancer
cells
gain
exceptional
mobility,
facilitating
their
invasion
distant
organs
and
establishment
secondary
malignancies.
We
thoroughly
examine
myriad
factors
influencing
encompassing
transcription
factors,
signalling
pathways,
metabolic
alterations,
microRNAs,
long
non‐coding
RNAs,
epigenetic
changes,
exosomal
interactions
intricate
dynamics
tumour
microenvironment.
Particularly,
emphasises
advanced
stages
crucial
for
development
highly
aggressive
phenotypes.
During
this
phase,
penetrate
vascular
barrier
exploit
bloodstream
to
propagate
life‐threatening
metastases
through
mesenchymal–epithelial
transition.
also
explore
EMT's
significant
fostering
dormancy,
senescence,
emergence
stem
formidable
challenge
therapeutic
resistance.
Our
transcends
mere
inventory
EMT‐inducing
elements;
it
critically
assesses
current
state
EMT‐focused
clinical
trials,
revealing
both
hurdles
breakthroughs.
Highlighting
potential
EMT
research,
we
project
its
transformative
impact
on
future
therapy.
exploration
is
aimed
at
paving
way
towards
an
era
effectively
managing
relentless
disease,
positioning
forefront
innovative
research
strategies.
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(4), С. 2128 - 2139
Опубликована: Апрель 3, 2024
Cancer
research
has
made
significant
progress
in
recent
years,
and
extracellular
vesicles
(EVs)
based
cancer
investigation
reveals
several
facts
about
cancer.
Exosomes
are
a
subpopulation
of
EVs.
In
the
present
decade,
exosomes
is
mostly
highlighted
for
theranostic
research.
Tumor
cell
derived
(TEXs)
promote
but
there
multiple
sources
that
can
be
used
as
therapeutic
agents
(plant
exosomes,
stem
cell-derived
modified
or
synthetic
exosomes).
Stem
cells
regenerative
medicine
faces
numerous
challenges,
such
tumor
development,
cellular
reprogramming
etc.,
therefore
addressing
these
complications
becomes
essential.
serves
an
answer
to
problems
offers
better
solution.
Global
indicates
also
play
dual
role
system
by
either
inhibiting
promoting
Modified
which
genetically
engineered
surface
increase
efficacy
properties
considered
target
above
concerns.
However,
difficulties
associated
with
include
variations
heterogenity,
isolation
protocols,
large
scale
production,
have
managed
effectively.
this
review,
we
explore
biogenesis,
exosome
sources,
drug
delivery,
clinical
trial
related
challenges
domain
future
orientation.
This
article
may
encourage
researchers
develop
effective
affordable
Clinical and Translational Discovery,
Год журнала:
2024,
Номер
4(4)
Опубликована: Июнь 27, 2024
Abstract
Exosomes,
are
a
subpopulation
of
extracellular
vesicles,
that
originate
from
endosomes.
The
major
role
exosomes
is
cellular
communication
(in
this
process
display
the
status
parental
cell's
nature,
healthy
or
cell
suffers
any
pathological
complication).
In
recent
decades,
research
evidence
highlighted
masterminds
cancer
development
and
they
appear
as
smart
solutions
for
early
diagnosis,
prognosis
therapeutic
(eg.
stem
cell,
plant
immune
cell‐derived
exosomes)
approaches.
Exosomes
transform
liquid
biopsy
into
new
orientation.
Several
biofluids
(blood,
plasma,
serum,
saliva,
urine,
CSF
(Cerebrospinal
Fluid)
tissue
used
exosome‐based
biomarkers
detection.
Liquid
becomes
more
efficient
exosomes,
compared
to
biopsy.
biocompatibility,
low
toxicity,
ability
cross
biological
membranes
make
it
potential
tool
development.
Exosome‐based
therapeutics
introduce
cutting‐edge
era
cell‐free
therapy.
This
article
explores
critical
in
development,
progression,
treatment,
clinical
trials.
trials
indicate
we
close
precision
medicine.
ACS Applied Bio Materials,
Год журнала:
2023,
Номер
7(1), С. 44 - 58
Опубликована: Дек. 18, 2023
Epithelial-mesenchymal
transition
(EMT)
is
a
fundamental
process
driving
cancer
metastasis,
transforming
non-motile
cells
into
motile
population
that
migrates
to
distant
organs
and
forms
secondary
tumors.
In
recent
years,
research
has
revealed
strong
connection
between
exosomes
the
EMT.
Exosomes,
subpopulation
of
extracellular
vesicles,
facilitate
cellular
communication
dynamically
regulate
various
aspects
including
immune
cell
suppression,
matrix
remodeling,
metastasis
initiation,
EMT
organ-specific
metastasis.
Tumor-derived
(TEXs)
their
molecular
cargo,
comprising
proteins,
lipids,
nucleic
acids,
carbohydrates,
are
essential
components
promote
in
cancer.
TEXs
miRNAs
play
crucial
role
reprogramming
tumor
microenvironment,
while
TEX
surface
integrins
contribute
Exosome-based
offers
deeper
understanding
about
an
effective
theranostic
platform
development.
Additionally,
therapeutic
sources
paving
way
for
innovative
treatment
this
Review,
we
spotlight
impact,
aiming
inspire
researchers
worldwide
explore
fascinating
field
more
ways.
ACS Biomaterials Science & Engineering,
Год журнала:
2023,
Номер
9(9), С. 5205 - 5221
Опубликована: Авг. 14, 2023
Glioblastoma
(GBM)
is
an
aggressive
type
of
cancer
that
has
led
to
the
death
a
large
population.
The
traditional
approach
fails
develop
solution
for
GBM's
suffering
life.
Extensive
research
into
tumor
microenvironments
(TME)
indicates
TME
extracellular
vesicles
(EVs)
play
vital
role
in
development
and
progression.
EVs
are
classified
microvacuoles,
apoptotic
bodies,
exosomes.
Exosomes
most
highlighted
domains
research.
GBM
cell-derived
exosomes
participate
multiple
progression
events
such
as
immune
suppression,
angiogenesis,
premetastatic
niche
formation
(PMN),
ECM
(extracellular
matrix),
EMT
(epithelial-to-mesenchymal
transition),
metastasis,
stem
cell
therapeutic
drug
resistance.
also
carry
signature
glioblastoma-related
status.
exosome-based
examination
part
new
generation
liquid
biopsy.
It
solved
early
diagnostic
limitations
GBM.
Traditional
approaches
do
not
cross
blood–brain
barrier
(BBB).
game
changer
treatment
it
emerging
potential
platform
effective,
efficient,
specific
development.
In
this
review,
we
have
explored
exosome–GBM
interlink,
clinical
impact
on
biomarkers,
therapeutics
GBM,
challenges,
future
directions
Therefore,
GBM-derived
offer
unique
opportunities,
which
currently
under
preclinical
testing.
