International Journal of Pharmaceutics,
Год журнала:
2022,
Номер
624, С. 122040 - 122040
Опубликована: Июль 25, 2022
Nuclear
medicine
imaging
plays
an
important
role
in
nanomedicine.
However,
it
is
still
challenging
to
develop
a
versatile
platform
make
the
nonviral
nanovectors
used
cancer
therapy
biotraceable.
In
present
study,
robust
approach
radiolabel
inorganic
for
SPECT
and
PET
was
developed.
The
based
on
bisphosphonates
(BP)
conjugated
nanovector,
mesoporous
silicon
(PSi)
nanoparticles.
BP
served
as
efficient
chelator
various
radionuclides.
For
both
of
99mTc
68Ga
radionuclides
utilized,
radiochemical
purity
yield
were
∼99%
∼90%,
respectively.
Because
short
decay
time
radionuclides,
easy,
fast
effective
PEGylation
method
developed
improve
residence
systemic
circulation.
Both
PEG-99mTc-BP-PSi
PEG-68Ga-BP-PSi
NPs,
where
performed
after
labeling,
had
excellent
colloidal
stability
vitro.
plain
particles
without
accumulated
reticuloendothelial
system
organs
upon
intravenous
administration,
while
prolonged
Overall,
proved
be
applicable
labeling
with
easily
robustly.
Considering
nature
nanoparticles,
does
not
hamper
addition
other
functionalities
vector,
nor
its
capability
carry
high
payloads.
Advances in Colloid and Interface Science,
Год журнала:
2022,
Номер
304, С. 102680 - 102680
Опубликована: Апрель 17, 2022
Polymer
capsules
fabricated
via
the
layer-by-layer
(LbL)
approach
have
attracted
a
great
deal
of
attention
for
biomedical
applications
thanks
to
their
tunable
architecture.
Compared
alternative
methods,
in
which
precise
control
over
final
properties
systems
is
usually
limited,
intrinsic
versatility
LbL
allows
functionalization
all
constituents
polymeric
following
relatively
simple
protocols.
In
fact,
can
be
adjusted
from
inner
cavity
outer
layer
through
shell,
resulting
therapeutic,
diagnostic,
or
theranostic
(i.e.,
combination
therapeutic
and
diagnostic)
agents
that
adapted
particular
characteristics
patient
face
challenges
encountered
complex
pathologies.
The
industry
demands
novel
biomaterials
capable
targeting
several
mechanisms
and/or
cellular
pathways
simultaneously
while
being
tracked
by
minimally
invasive
techniques,
thus
highlighting
need
shift
monofunctional
multifunctional
polymer
capsules.
present
review,
those
strategies
permit
advanced
are
accordingly
introduced.
Each
capsule
cavity,
multilayer
membrane
layer)
thoroughly
analyzed
overview
toward
fabrication
presented.
Special
emphasis
given
potential
these
capsules,
including
examples
performed
vitro
vivo
validation
studies.
Finally,
process
future
perspective
safe
translation
into
clinic
summarized.
Chemistry of Materials,
Год журнала:
2022,
Номер
34(14), С. 6593 - 6605
Опубликована: Июль 8, 2022
Biomedical
application
of
various
nanoparticles
(NPs)
for
bioimaging
and
therapeutic
purposes
attracts
huge
interest.
In
particular,
NPs
can
be
used
as
nanocarriers
radionuclides
radiotherapy
malignant
neoplasms.
However,
most
approaches
NP
radiolabeling
are
complicated,
their
transfer
into
clinical
practice
is
difficult
due
to
multistep
process,
limited
reproducibility,
lack
an
automated
procedure.
Here,
we
develop
a
universal
method
suitable
(either
organic
or
inorganic)
internal
B16-F10
melanoma
tumors.
The
obtained
(polylactide,
silica,
gold,
iron
oxide)
were
labeled
with
diagnostic
(99mTc)
(188Re)
high
efficiency
(∼94–98%)
radiochemical
stability
(>95%).
After
intratumoral
administration,
these
188Re-labeled
mostly
remained
in
the
tumor,
inhibiting
tumor
growth
rate
compared
untreated
absence
any
significant
leakage
radiolabeled
healthy
tissues
(the
liver,
heart,
kidneys,
lungs,
spleen)
was
confirmed
by
single-photon
emission
computed
tomography
(SPECT)
direct
radiometry
analysis.
Histological
analysis
revealed
no
abnormal
changes
organs
after
therapy
(e.g.,
acute
pathologic
findings
detected
liver
kidneys).
As
result,
treatment
mice
led
prolonged
survival
control
group.
Thus,
our
study
provides
general
guidance
use
different
types
radionuclide
therapy.
Expert Opinion on Drug Delivery,
Год журнала:
2021,
Номер
18(8), С. 1047 - 1066
Опубликована: Фев. 18, 2021
Introduction:
Gene
therapy
is
a
breakthrough
medical
field
which
focuses
on
the
therapeutic
delivery
of
recombinant
nucleic
acids
in
order
to
treat
or
prevent
broad
spectrum
diseases.
However,
number
important
obstacles
remain
before
its
wide
introduction
into
clinical
practice
can
be
envisaged.
One
biggest
bottlenecks
lack
efficient
and
safe
technologies,
particularly,
for
vivo
distribution.
Above
beyond
standard
requirements
carriers,
systems
gene
ideally
use
hit-and-run
principle
(to
minimize
off-target
effect
display
immunogenic
moieties).
None
currently
used
viral
vectors
fulfills
all
these
requirements.
Therefore,
growing
variety
non-viral
platforms
represents
promising
alternative.Areas
covered:
This
review
summarizes
Layer-by-Layer
(LbL)
approaches
that
effectively
delivery,
considering
various
examples
with
transfer
pDNA,
mRNA,
siRNA
as
well
genome-editing
tools.
Ex
modification
clinically
relevant
cells
aspects
possible
application
LbL
are
also
underlined.Expert
opinion:
The
technique
provides
opportunities
genetic
material
purposes
offers
promise
future
therapy.
Pharmaceutics,
Год журнала:
2023,
Номер
15(11), С. 2574 - 2574
Опубликована: Ноя. 2, 2023
The
widespread
application
of
calcium
carbonate
is
determined
by
its
high
availability
in
nature
and
simplicity
synthesis
laboratory
conditions.
Moreover,
possesses
highly
attractive
physicochemical
properties
that
make
it
suitable
for
a
wide
range
biomedical
applications.
This
review
provides
conclusive
analysis
the
results
on
using
tunable
vaterite
metastability
development
biodegradable
drug
delivery
systems
therapeutic
vehicles
with
controlled
sustained
release
incorporated
cargo.
manuscript
highlights
nuances
recrystallization
to
non-porous
calcite,
dissolution
at
acidic
pH,
biodegradation
vivo
conditions
control
over
these
processes.
outlines
main
benefits
instability
liberation
encapsulated
molecules
natural
synthetic
polymeric
materials
purposes.
Journal of Materials Chemistry B,
Год журнала:
2020,
Номер
8(41), С. 9576 - 9588
Опубликована: Янв. 1, 2020
The
polyelectrolyte
nanocarriers’
based
on
nanosized
vaterite
particles
as
a
novel
tool
for
genetic
material
delivery
into
the
clinically
relevant
cell
types
and
potential
application
of
described
technology
in
gene
therapy
approaches.
ACS Applied Materials & Interfaces,
Год журнала:
2021,
Номер
13(22), С. 25599 - 25610
Опубликована: Май 24, 2021
Actinium-225
(225Ac)
radiolabeled
submicrometric
core-shell
particles
(SPs)
made
of
calcium
carbonate
(CaCO3)
coated
with
biocompatible
polymers
[tannic
acid-human
serum
albumin
(TA/HSA)]
have
been
developed
to
improve
the
efficiency
local
α-radionuclide
therapy
in
melanoma
models
(B16-F10
tumor-bearing
mice).
The
225Ac-SPs
possess
radiochemical
stability
and
demonstrate
effective
retention
225Ac
its
daughter
isotopes.
SPs
additionally
labeled
zirconium-89
(89Zr)
perform
biodistribution
studies
using
positron
emission
tomography-computerized
tomography
(PET/CT)
imaging
for
14
days
after
intratumoral
injection.
According
PET/CT
analysis,
a
significant
accumulation
89Zr-SPs
tumor
area
is
revealed
whole
investigation
period,
which
correlates
direct
radiometry
analysis
administration
225Ac-SPs.
histological
has
no
abnormal
changes
healthy
tissue
organs
treatment
(e.g.,
acute
pathologic
findings
are
detected
liver
kidneys).
At
same
time,
inhibition
growth
observed
as
compared
control
samples
[nonradiolabeled
phosphate-buffered
saline
(PBS)].
mice
resulted
prolonged
survival
samples.
Thus,
our
study
validates
application
225Ac-doped
submicron
CaCO3
therapy.
