Encapsulation of a small-molecule drug based on substituted 2-aminothiophenes in calcium carbonate carriers for therapy of melanoma

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(13), P. 3431 - 3445

Published: Jan. 1, 2024

Encapsulation of 2-aminothiophenes in calcium carbonate particles leads to improved antitumor activity against melanoma.

Language: Английский

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Calcium carbonate carriers for combined chemo- and radionuclide therapy of metastatic lung cancer

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 344, P. 1 - 11

Published: Feb. 16, 2022

Language: Английский

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Exploiting the layer-by-layer nanoarchitectonics for the fabrication of polymer capsules: A toolbox to provide multifunctional properties to target complex pathologies

Advances in Colloid and Interface Science, Journal Year: 2022, Volume and Issue: 304, P. 102680 - 102680

Published: April 17, 2022

Polymer capsules fabricated via the layer-by-layer (LbL) approach have attracted a great deal of attention for biomedical applications thanks to their tunable architecture. Compared alternative methods, in which precise control over final properties systems is usually limited, intrinsic versatility LbL allows functionalization all constituents polymeric following relatively simple protocols. In fact, can be adjusted from inner cavity outer layer through shell, resulting therapeutic, diagnostic, or theranostic (i.e., combination therapeutic and diagnostic) agents that adapted particular characteristics patient face challenges encountered complex pathologies. The industry demands novel biomaterials capable targeting several mechanisms and/or cellular pathways simultaneously while being tracked by minimally invasive techniques, thus highlighting need shift monofunctional multifunctional polymer capsules. present review, those strategies permit advanced are accordingly introduced. Each capsule cavity, multilayer membrane layer) thoroughly analyzed overview toward fabrication presented. Special emphasis given potential these capsules, including examples performed vitro vivo validation studies. Finally, process future perspective safe translation into clinic summarized.

Language: Английский

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Universal Chelator-Free Radiolabeling of Organic and Inorganic-Based Nanocarriers with Diagnostic and Therapeutic Isotopes for Internal Radiotherapy

Chemistry of Materials, Journal Year: 2022, Volume and Issue: 34(14), P. 6593 - 6605

Published: July 8, 2022

Biomedical application of various nanoparticles (NPs) for bioimaging and therapeutic purposes attracts huge interest. In particular, NPs can be used as nanocarriers radionuclides radiotherapy malignant neoplasms. However, most approaches NP radiolabeling are complicated, their transfer into clinical practice is difficult due to multistep process, limited reproducibility, lack an automated procedure. Here, we develop a universal method suitable (either organic or inorganic) internal B16-F10 melanoma tumors. The obtained (polylactide, silica, gold, iron oxide) were labeled with diagnostic (99mTc) (188Re) high efficiency (∼94–98%) radiochemical stability (>95%). After intratumoral administration, these 188Re-labeled mostly remained in the tumor, inhibiting tumor growth rate compared untreated absence any significant leakage radiolabeled healthy tissues (the liver, heart, kidneys, lungs, spleen) was confirmed by single-photon emission computed tomography (SPECT) direct radiometry analysis. Histological analysis revealed no abnormal changes organs after therapy (e.g., acute pathologic findings detected liver kidneys). As result, treatment mice led prolonged survival control group. Thus, our study provides general guidance use different types radionuclide therapy.

Language: Английский

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Layer-by-Layer technique as a versatile tool for gene delivery applications

Expert Opinion on Drug Delivery, Journal Year: 2021, Volume and Issue: 18(8), P. 1047 - 1066

Published: Feb. 18, 2021

Introduction: Gene therapy is a breakthrough medical field which focuses on the therapeutic delivery of recombinant nucleic acids in order to treat or prevent broad spectrum diseases. However, number important obstacles remain before its wide introduction into clinical practice can be envisaged. One biggest bottlenecks lack efficient and safe technologies, particularly, for vivo distribution. Above beyond standard requirements carriers, systems gene ideally use hit-and-run principle (to minimize off-target effect display immunogenic moieties). None currently used viral vectors fulfills all these requirements. Therefore, growing variety non-viral platforms represents promising alternative.Areas covered: This review summarizes Layer-by-Layer (LbL) approaches that effectively delivery, considering various examples with transfer pDNA, mRNA, siRNA as well genome-editing tools. Ex modification clinically relevant cells aspects possible application LbL are also underlined.Expert opinion: The technique provides opportunities genetic material purposes offers promise future therapy.

Language: Английский

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Exploiting Benefits of Vaterite Metastability to Design Degradable Systems for Biomedical Applications

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(11), P. 2574 - 2574

Published: Nov. 2, 2023

The widespread application of calcium carbonate is determined by its high availability in nature and simplicity synthesis laboratory conditions. Moreover, possesses highly attractive physicochemical properties that make it suitable for a wide range biomedical applications. This review provides conclusive analysis the results on using tunable vaterite metastability development biodegradable drug delivery systems therapeutic vehicles with controlled sustained release incorporated cargo. manuscript highlights nuances recrystallization to non-porous calcite, dissolution at acidic pH, biodegradation vivo conditions control over these processes. outlines main benefits instability liberation encapsulated molecules natural synthetic polymeric materials purposes.

Language: Английский

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A highly efficient and safe gene delivery platform based on polyelectrolyte core–shell nanoparticles for hard-to-transfect clinically relevant cell types

Journal of Materials Chemistry B, Journal Year: 2020, Volume and Issue: 8(41), P. 9576 - 9588

Published: Jan. 1, 2020

The polyelectrolyte nanocarriers’ based on nanosized vaterite particles as a novel tool for genetic material delivery into the clinically relevant cell types and potential application of described technology in gene therapy approaches.

Language: Английский

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An investigation of calcium carbonate core-shell particles for incorporation of 225Ac and sequester of daughter radionuclides: in vitro and in vivo studies

Journal of Controlled Release, Journal Year: 2021, Volume and Issue: 330, P. 726 - 737

Published: Jan. 11, 2021

Language: Английский

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Calcium Carbonate Core–Shell Particles for Incorporation of ²²⁵Ac and Their Application in Local α-Radionuclide Therapy

ACS Applied Materials & Interfaces, Journal Year: 2021, Volume and Issue: 13(22), P. 25599 - 25610

Published: May 24, 2021

Actinium-225 (225Ac) radiolabeled submicrometric core-shell particles (SPs) made of calcium carbonate (CaCO3) coated with biocompatible polymers [tannic acid-human serum albumin (TA/HSA)] have been developed to improve the efficiency local α-radionuclide therapy in melanoma models (B16-F10 tumor-bearing mice). The 225Ac-SPs possess radiochemical stability and demonstrate effective retention 225Ac its daughter isotopes. SPs additionally labeled zirconium-89 (89Zr) perform biodistribution studies using positron emission tomography-computerized tomography (PET/CT) imaging for 14 days after intratumoral injection. According PET/CT analysis, a significant accumulation 89Zr-SPs tumor area is revealed whole investigation period, which correlates direct radiometry analysis administration 225Ac-SPs. histological has no abnormal changes healthy tissue organs treatment (e.g., acute pathologic findings are detected liver kidneys). At same time, inhibition growth observed as compared control samples [nonradiolabeled phosphate-buffered saline (PBS)]. mice resulted prolonged survival samples. Thus, our study validates application 225Ac-doped submicron CaCO3 therapy.

Language: Английский

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Core-Shell Nanoconstructs for Cancer-Based Biomedical Applications

Published: Jan. 1, 2025

Language: Английский

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