Cancer treatment: from traditional Chinese herbal medicine to the liposome delivery system DOI Creative Commons

Minhan Fu,

Xuan Han, Bin Chen

и другие.

Acta Materia Medica, Год журнала: 2022, Номер 1(4)

Опубликована: Дек. 14, 2022

Traditional Chinese herbal (TCH) medicines have emerged as a prospective and affordable method to treat various diseases with broad range of biological activity; however, traditional preparations, like decoctions, are often associated low bioavailability, thus resulting in limited efficacy against cancer. The drawbacks active TCH components, including instability, poor permeability, high hydrophilicity or hydrophobicity, undesirable pharmacokinetic profiles, off-target toxicity, also exist. Most clinical alternative for the treatment chronic diseases. A liposomal delivery system is most common class FDA-approved nanomedicines, which has improved pharmacokinetics, enhanced targetability, reduced side effects. Therefore, we anticipate that technology will help concentrate drugs inside tumors, fully release therapeutic potential reduce effects medicines. review provides brief overview several representative components related liposome strategies cancer therapy. Current challenges targeting discussed interested researchers.

Язык: Английский

Extracellular Vesicles in Cancer Drug Resistance: Roles, Mechanisms, and Implications DOI Creative Commons

Yang Qiu-rong,

Jing Xu, Jianmei Gu

и другие.

Advanced Science, Год журнала: 2022, Номер 9(34)

Опубликована: Окт. 17, 2022

Abstract Extracellular vesicles (EVs) are cell‐derived nanosized that mediate cell‐to‐cell communication via transporting bioactive molecules and thus critically involved in various physiological pathological conditions. EVs contribute to different aspects of cancer progression, such as growth, angiogenesis, metastasis, immune evasion, drug resistance. induce the resistance cells chemotherapy, radiotherapy, targeted therapy, antiangiogenesis immunotherapy by transferring specific cargos affect efflux regulate signaling pathways associated with epithelial‐mesenchymal transition, autophagy, metabolism, stemness. In addition, modulate reciprocal interaction between noncancer tumor microenvironment (TME) develop therapy detectable many biofluids patients, regarded novel biomarkers for monitoring response predicting prognosis. Moreover, suggested promising targets engineered nanovehicles deliver drugs overcoming therapy. this review, biological roles their mechanisms action summarized. The preclinical studies on using also discussed.

Язык: Английский

Процитировано

86
Capsaicin-loaded alginate nanoparticles embedded polycaprolactone-chitosan nanofibers as a controlled drug delivery nanoplatform for anticancer activity DOI
Azin Rashidy Ahmady, Atefeh Solouk, Saeed Saber‐Samandari

и другие.

Journal of Colloid and Interface Science, Год журнала: 2023, Номер 638, С. 616 - 628

Опубликована: Янв. 31, 2023

Язык: Английский

Процитировано

66
Anti-cancer activity of sustained release capsaicin formulations DOI Creative Commons

Justin C. Merritt,

Stephen D. Richbart,

Emily G. Moles

и другие.

Pharmacology & Therapeutics, Год журнала: 2022, Номер 238, С. 108177 - 108177

Опубликована: Март 26, 2022

Язык: Английский

Процитировано

56
Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer DOI Creative Commons

Tomi Lois Adetunji,

Femi Olawale, Chijioke Olisah

и другие.

Frontiers in Oncology, Год журнала: 2022, Номер 12

Опубликована: Июль 13, 2022

Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is one of the most important natural products in genus Capsicum. Due to its numerous biological effects, there has been extensive and increasing research interest capsaicin, resulting increased scientific publications recent years. Therefore, an in-depth bibliometric analysis published literature on capsaicin from 2001 2021 was performed assess global status, thematic emerging areas, potential insights into future research. Furthermore, advances combination therapy human cancer as well their mechanisms action were described. In last two decades, outputs have by estimated 18% per year dominated articles at 93% 3753 assessed literature. addition, anti-cancer/pharmacokinetics, cytotoxicity, vivo neurological pain studies keyword clusters generated designated domains for It evident that United States, China, Japan accounted about 42% met inclusion criteria. Also, visibly dominant collaboration nodes networks with other identified countries established. Assessment eligible revealed mitigating mainly entailed chemo-preventive which often linked ability exert multi-biological effects such anti-mutagenic, antioxidant anti-inflammatory activities. However, clinical limited, may be related some inherent challenges associated limited trials. This review presents a novel approach visualizing information comprehensive perspective therapeutic significance applications treatment cancer.

Язык: Английский

Процитировано

42
Recent Advances in Glycyrrhetinic Acid-Functionalized Biomaterials for Liver Cancer-Targeting Therapy DOI Creative Commons
Antonio Speciale, Claudia Muscarà, Maria Sofia Molonia

и другие.

Molecules, Год журнала: 2022, Номер 27(6), С. 1775 - 1775

Опубликована: Март 8, 2022

Liver cancer is one of the most common causes mortality worldwide. Chemotherapy and radiotherapy are conventional therapies generally employed in patients with liver tumors. The major issue associated administration chemotherapeutics their high toxicity lack selectivity, leading to systemic that can be detrimental patient's quality life. An important approach development original liver-targeted therapeutic products takes advantage employment biologically active ligands able bind specific receptors on cytoplasmatic membranes cells. In this perspective, glycyrrhetinic acid (GA), a pentacyclic triterpenoid present roots rhizomes licorice, has been used as ligand for targeting due expression GA sinusoidal surface mammalian hepatocytes, so it may modify drug delivery systems (DDSs) obtain better or hepatocyte uptake efficacy. current review, we focus recent interesting research advances GA-based hybrid compounds DDSs developed potential efficacious options treatment hepatic cancer.

Язык: Английский

Процитировано

41
Curcumin in the treatment of liver cancer: From mechanisms of action to nanoformulations DOI
Sulieman Ibraheem Shelash Al‐Hawary, Saade Abdalkareem Jasim, Mustafa M. Kadhim

и другие.

Phytotherapy Research, Год журнала: 2023, Номер 37(4), С. 1624 - 1639

Опубликована: Март 8, 2023

Abstract Liver cancer is the sixth most prevalent and ranks third in cancer‐related death, after lung colorectal cancer. Various natural products have been discovered as alternatives to conventional therapy strategies, including radiotherapy, chemotherapy, surgery. Curcumin (CUR) with antiinflammatory, antioxidant, antitumor activities has associated therapeutic benefits against various cancers. It can regulate multiple signaling pathways, such PI3K/Akt, Wnt/β‐catenin, JAK/STAT, p53, MAPKs, NF‐ĸB, which are involved cell proliferation, metastasis, apoptosis, angiogenesis, autophagy. Due its rapid metabolism, poor oral bioavailability, low solubility water, CUR application clinical practices restricted. To overcome these limitations, nanotechnology‐based delivery systems applied use nanoformulations added benefits, reducing toxicity, improving cellular uptake, targeting tumor sites. Besides anticancer of combating cancers, especially liver cancer, here we focused on nanoformulations, micelles, liposomes, polymeric, metal, solid lipid nanoparticles, others, treatment

Язык: Английский

Процитировано

34
Therapeutic potential and limitations of curcumin as antimetastatic agent DOI Creative Commons
Petr Dytrych, Zdeněk Kejík, Jan Hajduch

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 163, С. 114758 - 114758

Опубликована: Май 2, 2023

Treatment of metastatic cancer is one the biggest challenges in anticancer therapy. Curcumin interesting nature polyphenolic compound with unique biological and medicinal effects, including repression metastases. High impact studies imply that curcumin can modulate immune system, independently target various signalling pathways, repress migration invasiveness cells. This review discusses potential as an antimetastatic agent describes mechanisms its activity. In addition, possible strategies (curcumin formulation, optimization method administration modification structure motif) to overcome limitation such low solubility bioactivity are also presented. These discussed context clinical trials relevant studies.

Язык: Английский

Процитировано

31
Dual-drug codelivery nanosystems: An emerging approach for overcoming cancer multidrug resistance DOI Open Access
Jianing Gong,

Taoran Shi,

Jinfeng Liu

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 161, С. 114505 - 114505

Опубликована: Март 13, 2023

Multidrug resistance (MDR) promotes tumor recurrence and metastasis heavily reduces anticancer efficiency, which has become a primary reason for the failure of clinical chemotherapy. The mechanisms MDR are so complex that conventional chemotherapy usually fails to achieve an ideal therapeutic effect even accelerates occurrence MDR. In contrast, combination with dual-drug significant advantages in therapy. A novel codelivery nanosystem, combines administration nanotechnology, can overcome application limitation free drugs. Both characteristics nanoparticles synergistic dual drugs contribute circumventing various drug-resistant cells. Therefore, developing nanosystems different multidrug-resistant important reference value reversing enhancing antitumor effect. this review, advantages, principles, common nanocarriers systems summarized. molecular designed based on mainly introduced. Meanwhile, development prospects challenges also discussed, provide guidelines exploit optimized combined strategies future.

Язык: Английский

Процитировано

28
A Dual‐Targeting Liposome Enhances Triple‐Negative Breast Cancer Chemoimmunotherapy through Inducing Immunogenic Cell Death and Inhibiting STAT3 Activation DOI
Kaipei Luo, Lu Yang, Chunmei Yan

и другие.

Small, Год журнала: 2023, Номер 19(40)

Опубликована: Июнь 1, 2023

Immunotherapy gains increasing focus in treating triple-negative breast cancer (TNBC), while its efficacy is greatly restricted owing to low tumor immunogenicity and immunosuppressive microenvironment (ITM). Herein, a LyP-1 chondroitin sulfate (CS) dual-modified liposome co-loaded with paclitaxel (PTX) cryptotanshinone (CTS), namely CS/LyP-1-PC Lip, engineered for TNBC chemoimmunotherapy via induction of immunogenic cell death (ICD) inhibition signal transducer activator transcript-3 (STAT3) activation. Lip enhances cellular uptake through p32 CD44 dual receptor-mediated endocytosis. Within the tumor, CS layer continuously detached by hyaluronidase release drugs. Subsequently, CTS sensitizes cytotoxicity PTX 4T1 cells. induces ICD cells facilitates infiltration cytotoxic T lymphocyte provoke immune response. Meanwhile, concomitant delivery inhibits STAT3 activation decrease regulatory cell, M2-type tumor-associated macrophage, myeloid-derived suppressor thus reversing ITM. Markedly, dual-targeting shows superior anti-tumor subcutaneous mice significant lung metastasis suppression model. Overall, this work offers feasible combination regimen promising nanoplatform development chemoimmunotherapy.

Язык: Английский

Процитировано

24
Co-delivery of camptothecin and MiR-145 by lipid nanoparticles for MRI-visible targeted therapy of hepatocellular carcinoma DOI Creative Commons

Rong Jing,

Tongtong Liu,

Xiujuan Yin

и другие.

Journal of Experimental & Clinical Cancer Research, Год журнала: 2024, Номер 43(1)

Опубликована: Авг. 30, 2024

Camptothecin (CPT) is one of the frequently used small chemotherapy drugs for treating hepatocellular carcinoma (HCC), but its clinical application limited due to severe toxicities and acquired resistance. Combined chemo-gene therapy has been reported be an effective strategy counteracting drug resistance while sensitizing cancer cells cytotoxic agents. Thus, we hypothesized that combining CPT with miR-145 could synergistically suppress tumor proliferation enhance anti-tumor activity.

Язык: Английский

Процитировано

14