Capsaicin and TRPV1: A Novel Therapeutic Approach to Mitigate Vascular Aging DOI Creative Commons

Xingyu Cui,

Jun‐Kun Zhan

Aging and Disease, Journal Year: 2025, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2025

Vascular aging and its associated diseases represent a principal cause of mortality among the global elderly population, making mitigation vascular significant aspiration for humanity. This article explores intersection nature health, focusing on role natural plant, pepper, bioactive compound, capsaicin, in combating aging. By examining molecular cellular mechanisms as well phenotypic alterations blood vessels, we offer comprehensive review effects capsaicin receptor, transient receptor potential vanilloid 1 (TRPV1), within We propose that may serve medication with to slow progress could constitute new strategy treat related disease.

Language: Английский

Extracellular Vesicles in Cancer Drug Resistance: Roles, Mechanisms, and Implications DOI Creative Commons

Yang Qiu-rong,

Jing Xu, Jianmei Gu

et al.

Advanced Science, Journal Year: 2022, Volume and Issue: 9(34)

Published: Oct. 17, 2022

Abstract Extracellular vesicles (EVs) are cell‐derived nanosized that mediate cell‐to‐cell communication via transporting bioactive molecules and thus critically involved in various physiological pathological conditions. EVs contribute to different aspects of cancer progression, such as growth, angiogenesis, metastasis, immune evasion, drug resistance. induce the resistance cells chemotherapy, radiotherapy, targeted therapy, antiangiogenesis immunotherapy by transferring specific cargos affect efflux regulate signaling pathways associated with epithelial‐mesenchymal transition, autophagy, metabolism, stemness. In addition, modulate reciprocal interaction between noncancer tumor microenvironment (TME) develop therapy detectable many biofluids patients, regarded novel biomarkers for monitoring response predicting prognosis. Moreover, suggested promising targets engineered nanovehicles deliver drugs overcoming therapy. this review, biological roles their mechanisms action summarized. The preclinical studies on using also discussed.

Language: Английский

Citations

82
Capsaicin-loaded alginate nanoparticles embedded polycaprolactone-chitosan nanofibers as a controlled drug delivery nanoplatform for anticancer activity DOI
Azin Rashidy Ahmady, Atefeh Solouk, Saeed Saber‐Samandari

et al.

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 638, P. 616 - 628

Published: Jan. 31, 2023

Language: Английский

Citations

66
Anti-cancer activity of sustained release capsaicin formulations DOI Creative Commons

Justin C. Merritt,

Stephen D. Richbart,

Emily G. Moles

et al.

Pharmacology & Therapeutics, Journal Year: 2022, Volume and Issue: 238, P. 108177 - 108177

Published: March 26, 2022

Language: Английский

Citations

51
Recent Advances in Glycyrrhetinic Acid-Functionalized Biomaterials for Liver Cancer-Targeting Therapy DOI Creative Commons
Antonio Speciale, Claudia Muscarà, Maria Sofia Molonia

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(6), P. 1775 - 1775

Published: March 8, 2022

Liver cancer is one of the most common causes mortality worldwide. Chemotherapy and radiotherapy are conventional therapies generally employed in patients with liver tumors. The major issue associated administration chemotherapeutics their high toxicity lack selectivity, leading to systemic that can be detrimental patient's quality life. An important approach development original liver-targeted therapeutic products takes advantage employment biologically active ligands able bind specific receptors on cytoplasmatic membranes cells. In this perspective, glycyrrhetinic acid (GA), a pentacyclic triterpenoid present roots rhizomes licorice, has been used as ligand for targeting due expression GA sinusoidal surface mammalian hepatocytes, so it may modify drug delivery systems (DDSs) obtain better or hepatocyte uptake efficacy. current review, we focus recent interesting research advances GA-based hybrid compounds DDSs developed potential efficacious options treatment hepatic cancer.

Language: Английский

Citations

40
Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer DOI Creative Commons

Tomi Lois Adetunji,

Femi Olawale, Chijioke Olisah

et al.

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: July 13, 2022

Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is one of the most important natural products in genus Capsicum. Due to its numerous biological effects, there has been extensive and increasing research interest capsaicin, resulting increased scientific publications recent years. Therefore, an in-depth bibliometric analysis published literature on capsaicin from 2001 2021 was performed assess global status, thematic emerging areas, potential insights into future research. Furthermore, advances combination therapy human cancer as well their mechanisms action were described. In last two decades, outputs have by estimated 18% per year dominated articles at 93% 3753 assessed literature. addition, anti-cancer/pharmacokinetics, cytotoxicity, vivo neurological pain studies keyword clusters generated designated domains for It evident that United States, China, Japan accounted about 42% met inclusion criteria. Also, visibly dominant collaboration nodes networks with other identified countries established. Assessment eligible revealed mitigating mainly entailed chemo-preventive which often linked ability exert multi-biological effects such anti-mutagenic, antioxidant anti-inflammatory activities. However, clinical limited, may be related some inherent challenges associated limited trials. This review presents a novel approach visualizing information comprehensive perspective therapeutic significance applications treatment cancer.

Language: Английский

Citations

39
Curcumin in the treatment of liver cancer: From mechanisms of action to nanoformulations DOI
Sulieman Ibraheem Shelash Al‐Hawary, Saade Abdalkareem Jasim, Mustafa M. Kadhim

et al.

Phytotherapy Research, Journal Year: 2023, Volume and Issue: 37(4), P. 1624 - 1639

Published: March 8, 2023

Abstract Liver cancer is the sixth most prevalent and ranks third in cancer‐related death, after lung colorectal cancer. Various natural products have been discovered as alternatives to conventional therapy strategies, including radiotherapy, chemotherapy, surgery. Curcumin (CUR) with antiinflammatory, antioxidant, antitumor activities has associated therapeutic benefits against various cancers. It can regulate multiple signaling pathways, such PI3K/Akt, Wnt/β‐catenin, JAK/STAT, p53, MAPKs, NF‐ĸB, which are involved cell proliferation, metastasis, apoptosis, angiogenesis, autophagy. Due its rapid metabolism, poor oral bioavailability, low solubility water, CUR application clinical practices restricted. To overcome these limitations, nanotechnology‐based delivery systems applied use nanoformulations added benefits, reducing toxicity, improving cellular uptake, targeting tumor sites. Besides anticancer of combating cancers, especially liver cancer, here we focused on nanoformulations, micelles, liposomes, polymeric, metal, solid lipid nanoparticles, others, treatment

Language: Английский

Citations

34
Dual-drug codelivery nanosystems: An emerging approach for overcoming cancer multidrug resistance DOI Open Access
Jianing Gong,

Taoran Shi,

Jinfeng Liu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 161, P. 114505 - 114505

Published: March 13, 2023

Multidrug resistance (MDR) promotes tumor recurrence and metastasis heavily reduces anticancer efficiency, which has become a primary reason for the failure of clinical chemotherapy. The mechanisms MDR are so complex that conventional chemotherapy usually fails to achieve an ideal therapeutic effect even accelerates occurrence MDR. In contrast, combination with dual-drug significant advantages in therapy. A novel codelivery nanosystem, combines administration nanotechnology, can overcome application limitation free drugs. Both characteristics nanoparticles synergistic dual drugs contribute circumventing various drug-resistant cells. Therefore, developing nanosystems different multidrug-resistant important reference value reversing enhancing antitumor effect. this review, advantages, principles, common nanocarriers systems summarized. molecular designed based on mainly introduced. Meanwhile, development prospects challenges also discussed, provide guidelines exploit optimized combined strategies future.

Language: Английский

Citations

26
Therapeutic potential and limitations of curcumin as antimetastatic agent DOI Creative Commons
Petr Dytrych, Zdeněk Kejík, Jan Hajduch

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 163, P. 114758 - 114758

Published: May 2, 2023

Treatment of metastatic cancer is one the biggest challenges in anticancer therapy. Curcumin interesting nature polyphenolic compound with unique biological and medicinal effects, including repression metastases. High impact studies imply that curcumin can modulate immune system, independently target various signalling pathways, repress migration invasiveness cells. This review discusses potential as an antimetastatic agent describes mechanisms its activity. In addition, possible strategies (curcumin formulation, optimization method administration modification structure motif) to overcome limitation such low solubility bioactivity are also presented. These discussed context clinical trials relevant studies.

Language: Английский

Citations

26
A Dual‐Targeting Liposome Enhances Triple‐Negative Breast Cancer Chemoimmunotherapy through Inducing Immunogenic Cell Death and Inhibiting STAT3 Activation DOI
Kaipei Luo, Lu Yang, Chunmei Yan

et al.

Small, Journal Year: 2023, Volume and Issue: 19(40)

Published: June 1, 2023

Immunotherapy gains increasing focus in treating triple-negative breast cancer (TNBC), while its efficacy is greatly restricted owing to low tumor immunogenicity and immunosuppressive microenvironment (ITM). Herein, a LyP-1 chondroitin sulfate (CS) dual-modified liposome co-loaded with paclitaxel (PTX) cryptotanshinone (CTS), namely CS/LyP-1-PC Lip, engineered for TNBC chemoimmunotherapy via induction of immunogenic cell death (ICD) inhibition signal transducer activator transcript-3 (STAT3) activation. Lip enhances cellular uptake through p32 CD44 dual receptor-mediated endocytosis. Within the tumor, CS layer continuously detached by hyaluronidase release drugs. Subsequently, CTS sensitizes cytotoxicity PTX 4T1 cells. induces ICD cells facilitates infiltration cytotoxic T lymphocyte provoke immune response. Meanwhile, concomitant delivery inhibits STAT3 activation decrease regulatory cell, M2-type tumor-associated macrophage, myeloid-derived suppressor thus reversing ITM. Markedly, dual-targeting shows superior anti-tumor subcutaneous mice significant lung metastasis suppression model. Overall, this work offers feasible combination regimen promising nanoplatform development chemoimmunotherapy.

Language: Английский

Citations

23
Co-delivery of camptothecin and MiR-145 by lipid nanoparticles for MRI-visible targeted therapy of hepatocellular carcinoma DOI Creative Commons

Rong Jing,

Tongtong Liu,

Xiujuan Yin

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2024, Volume and Issue: 43(1)

Published: Aug. 30, 2024

Camptothecin (CPT) is one of the frequently used small chemotherapy drugs for treating hepatocellular carcinoma (HCC), but its clinical application limited due to severe toxicities and acquired resistance. Combined chemo-gene therapy has been reported be an effective strategy counteracting drug resistance while sensitizing cancer cells cytotoxic agents. Thus, we hypothesized that combining CPT with miR-145 could synergistically suppress tumor proliferation enhance anti-tumor activity.

Language: Английский

Citations

12