Advanced Healthcare Materials,
Год журнала:
2023,
Номер
13(4)
Опубликована: Ноя. 9, 2023
Abstract
Photodynamic
therapy
(PDT)
is
a
promising
approach
for
tumor
treatment;
however,
the
therapeutic
resistance
of
cancer
stem
cells
(CSCs)
severely
limits
its
efficacy
and
easily
lead
to
recurrence.
Herein,
hyaluronic
acid
(HA)‐Ce6‐Olaparib
(OLA)
micelle
(HCCO)
developed,
which
combines
CSC
targeting
HA,
PDT
effect
Ce6,
DNA
damage
repair
inhibition
OLA.
More
importantly,
HCCO
induces
immunogenic
cell
death
(ICD)
effects,
promotes
dendritic
maturation,
alleviates
myeloid‐derived
suppressor
(MDSCs)
infiltration
reverse
resistance.
As
result,
not
only
significantly
inhibits
growth
4T1
breast
CSCs
in
vitro,
but
also
effectively
recurrence
metastasis
vivo.
This
study
provides
novel
strategy
preventing
by
combination
inhibiting
repair,
reversing
resistance,
enhancing
PDT.
Advanced Materials,
Год журнала:
2024,
Номер
36(19)
Опубликована: Янв. 22, 2024
Abstract
Nanocarbons
are
emerging
at
the
forefront
of
nanoscience,
with
diverse
carbon
nanoforms
over
past
two
decades.
Early
cancer
diagnosis
and
therapy,
driven
by
advanced
chemistry
techniques,
play
a
pivotal
role
in
mitigating
mortality
rates
associated
cancer.
Nanocarbons,
an
attractive
combination
well‐defined
architectures,
biocompatibility,
nanoscale
dimension,
offer
incredibly
versatile
platform
for
imaging
therapy.
This
paper
aims
to
review
underlying
principles
regarding
controllable
synthesis,
fluorescence
origins,
cellular
toxicity,
surface
functionalization
routes
several
classes
nanocarbons:
nanodots,
nanodiamonds,
nanoonions,
nanohorns.
also
highlights
recent
breakthroughs
green
synthesis
different
nanocarbons
from
renewable
sources.
It
presents
comprehensive
unified
overview
latest
cancer‐related
applications
how
they
can
be
designed
interface
biological
systems
work
as
diagnostics
therapeutic
tools.
The
commercial
status
large‐scale
manufacturing
is
presented.
Finally,
it
proposes
future
research
opportunities
aimed
engendering
modifiable
high‐performance
across
medical
industries.
envisioned
cornerstone
guide
interdisciplinary
teams
crafting
fluorescent
tailored
attributes
that
revolutionize
Abstract
Surface‐enhanced
Raman
scattering
(SERS)
imaging
integrating
photothermal
and
photodynamic
therapy
(PTT/PDT)
is
a
promising
approach
for
achieving
accurate
diagnosis
effective
treatment
of
cancers.
However,
most
available
reporters
show
multiple
signals
in
the
fingerprint
region,
which
overlap
with
background
from
cellular
biomolecules.
Herein,
4T1
cell
membrane‐enveloped
gold
nanorods‐manganese
porphyrins
system
(GMCMs)
designed
successfully
fabricated
as
biomimetic
theranostic
nanoplatform.
Manganese
are
adsorbed
on
surface
Au
nanorods
via
terminal
alkynyl
group.
Cell
membrane
encapsulation
protects
manganese
falling
off
nanorods.
The
GMCMs
confirm
specific
homologous
targeting
to
cells
good
dispersibility,
excellent
photoacoustic
(PA)
properties,
preferable
1
O
2
generation
performance.
exhibit
distinct
SERS
silent
region
without
endogenous
biomolecule
interference
both
vitro
vivo.
ions
could
not
only
quench
fluorescence
enhance
effect
but
also
deplete
GSH
increase
yield.
Both
vivo
studies
demonstrate
that
effectively
eradicate
tumors
through
SERS/PA
imaging‐guided
PTT/PDT.
This
study
provides
feasible
strategy
augmenting
effects
group
GSH‐depletion
PTT/PDT
efficacy.
Abstract
Glutathione
(GSH)
is
the
primary
antioxidant
in
cells,
and
GSH
consumption
will
break
redox
balance
cells.
Based
on
this,
a
method
that
uses
high
concentrations
of
tumor
microenvironment
to
trigger
reaction
Cu(II)
generate
copper
nanoprobes
with
fluorescence
growth
inhibition
properties
proposed.
The
nanoprobe
mainly
exists
form
Cu(I)
catalyzes
decomposition
hydrogen
peroxide
into
hydroxyl
radicals.
At
same
time,
simple
controllable
carbon
micro‐nano
electrode
used
construct
single‐cell
sensing
platform,
which
enable
detection
glutathione
content
single
living
cells
after
treatment,
providing
an
excellent
example
for
detecting
biomolecules.
ABSTRACT
Imaging‐guided
phototherapy
holds
promise
for
precision
cancer
treatment.
However,
most
photosensitizers
have
only
a
singular
modality
of
photodynamic
therapy
(PDT)
or
photothermal
(PTT),
which
make
their
therapeutic
efficacy
severely
limited
by
the
hypoxic
and
complex
tumor
microenvironment
(TME).
In
this
article,
we
provide
smart
platform
design
(BOD‐D)
based
on
visualized
light‐triggered
phototherapeutic
switch
transforming
from
near‐infrared
(NIR)‐I
imaging‐guided
PDT
to
activatable
NIR‐II‐guided
PTT
while
releasing
nitric
oxide
(NO)
gas
(GT).
BOD‐D
releases
native
NIR
one‐region
fluorescence
signals
in
tumors,
is
used
direct
robust
killing.
As
administered,
decreasing
oxygen
content
TME
becomes
progressively
insufficient
maintain
its
excellent
cell‐killing
effect.
Subsequently,
light
triggers
dissociation
NO
BOD‐D,
activating
agent
BOD‐T
that
emits
NIR‐II
fluorescence,
subsequent
PTT.
Notably,
not
light‐mediated
mechanism
can
be
switched
NIR‐I‐guided
PTT,
but
also
released
during
process
will
GT
sensitize
above
Our
study
contributes
intelligent
cascade
photoablation.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(29)
Опубликована: Июль 22, 2024
Reactive
oxygen
species
(ROS),
as
metabolic
byproducts,
play
pivotal
role
in
physiological
and
pathological
processes.
Recently,
studies
on
the
regulation
of
ROS
levels
for
disease
treatments
have
attracted
extensive
attention,
mainly
involving
ROS-induced
toxicity
therapy
mediated
by
producers
antioxidant
scavengers.
Nanotechnology
advancements
led
to
development
numerous
nanomaterials
with
ROS-modulating
capabilities,
among
which
carbon
dots
(CDs)
standing
out
noteworthy
nanomedicines
own
their
distinctive
physicochemical
properties,
high
stability,
excellent
biocompatibility.
Despite
progress
treating
ROS-related
diseases
based
CDs,
critical
issues
such
rational
design
principles
remain
underexplored.
The
primary
cause
these
may
stem
from
intricate
amalgamation
core
structure,
defects,
surface
states,
inherent
poses
challenges
establishing
a
consistent
generalization.
This
review
succinctly
summarizes
recently
ROS-modulated
approaches
using
CDs
treatment.
Specifically,
it
investigates
established
therapeutic
strategies
CDs-regulated
ROS,
emphasizing
interplay
between
intrinsic
structure
generation
or
scavenging
ability.
conclusion
raises
several
unresolved
key
scientific
prominent
technological
bottlenecks,
explores
future
perspectives
comprehensive
CDs-based
therapy.
